Fragment-Based Phenotypic Lead Discovery To Identify New Drug Seeds That Target Infectious Diseases

Fragment-based lead discovery has emerged over the last decades as one of the most powerful techniques for identifying starting chemical matter to target specific proteins or nucleic acids in vitro. However, the use of such low-molecular-weight fragment molecules in cell-based phenotypic assays has...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	ACS chemical biology 2021-11, Vol.16 (11), p.2158-2163
Hauptverfasser:	Ayotte, Yann, Bernet, Eve, Bilodeau, François, Cimino, Mena, Gagnon, Dominic, Lebughe, Marthe, Mistretta, Maxime, Ogadinma, Paul, Ouali, Sarah-Lisa, Sow, Aïssatou Aïcha, Chatel-Chaix, Laurent, Descoteaux, Albert, Manina, Giulia, Richard, Dave, Veyrier, Frédéric, LaPlante, Steven R
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Infective Agents Anti-Infective Agents - chemistry Anti-Infective Agents - pharmacology Drug Discovery Drug Evaluation, Preclinical Life Sciences Structure-Activity Relationship
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!