Cyclophilin D Regulates Antiviral CD8 + T Cell Survival in a Cell-Extrinsic Manner

CD8 T cell-mediated immunity is critical for host defense against viruses and requires mitochondria-mediated type I IFN (IFN-I) signaling for optimal protection. Cyclophilin D (CypD) is a mitochondrial matrix protein that modulates the mitochondrial permeability transition pore, but its role in IFN-...

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Veröffentlicht in:	ImmunoHorizons 2020-04, Vol.4 (4), p.217-230
Hauptverfasser:	Condotta, Stephanie A, Downey, Jeffrey, Pardy, Ryan D, Valbon, Stefanie F, Tarrab, Esther, Lamarre, Alain, Divangahi, Maziar, Richer, Martin J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive Transfer Adoptive Transfer - methods Animals CD8 Antigens CD8 Antigens - metabolism CD8-Positive T-Lymphocytes CD8-Positive T-Lymphocytes - immunology Cell Survival Cell Survival - genetics Cyclophilin D Female Host Microbial Interactions Host Microbial Interactions - genetics Host Microbial Interactions - immunology Life Sciences Lymphocytic Choriomeningitis Lymphocytic Choriomeningitis - immunology Lymphocytic Choriomeningitis - therapy Lymphocytic Choriomeningitis - virology Lymphocytic choriomeningitis virus Lymphocytic choriomeningitis virus - immunology Macrophages Macrophages - immunology Male Mice Mice, Inbred C57BL Mice, Knockout Mitochondria Mitochondria - immunology Mitochondria - metabolism Peptidyl-Prolyl Isomerase F - genetics Peptidyl-Prolyl Isomerase F - metabolism Receptors, Antigen, T-Cell Receptors, Antigen, T-Cell - genetics Receptors, Antigen, T-Cell - metabolism Signal Transduction Signal Transduction - genetics
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