Pivotal role of PIM2 kinase in plasmablast generation and plasma cell survival, opening new treatment options in myeloma

The differentiation of B cells into plasmablasts (PBs) and then plasma cells (PCs) is associated with extensive cell reprogramming and new cell functions. By using specific inhibition strategies (including a novel morpholino RNA antisense approach), we found that early, sustained upregulation of the...

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Veröffentlicht in:	Blood 2022-02, Vol.139 (15), p.2316-2337
Hauptverfasser:	Haas, Marion, Caron, Gersende, Chatonnet, Fabrice, Manenti, Stephane, Alaterre, Elina, Devin, Julie, Delaloy, Céline, Bertolin, Giulia, Viel, Roselyne, Pignarre, Amandine, Llamas Gutierrez, Francisco, Marchalot, Anne, Decaux, Olivier, Tarte, Karin, Delpy, Laurent, Moreaux, Jerome, Fest, Thierry
Format:	Artikel
Sprache:	eng
Schlagworte:	Cancer Immunology Life Sciences
Online-Zugang:	Volltext
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