Obesity due to Steroid Receptor Coactivator-1 deficiency is associated with endocrine and metabolic abnormalities

Context Genetic variants affecting the nuclear hormone receptor coactivator Steroid Receptor Coactivator, SRC-1, have been identified in people with severe obesity and impair melanocortin signaling in cells and mice. As a result, obese patients with SRC-1 deficiency are being treated with a Melanoco...

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Veröffentlicht in:	The journal of clinical endocrinology and metabolism 2022-02
Hauptverfasser:	Cacciottolo, Tessa M, Henning, Elana, Keogh, Julia M, Bel Lassen, Pierre, Lawler, Katherine, Bounds, Rebecca, Ahmed, Rachel, Perdikari, Aliki, Mendes de Oliveira, Edson, Smith, Miriam, Godfrey, Edmund M, Johnson, Elspeth, Hodson, Leanne, Clément, Karine, van Der Klaauw, Agatha A, Farooqi, I Sadaf Sadaf
Format:	Artikel
Sprache:	eng
Schlagworte:	Food and Nutrition Life Sciences
Online-Zugang:	Volltext
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