An efficient synthesis of pyrido-imidazodiazepinediones

We herein report the synthesis of a series of 12 optically pure 3,4-dihydro-1H-pyrido-[1′,2′:1,2]-imidazo[4,5-d][1,3]diazepine-2,5-diones, which form a new family of azaheterocycle-fused [1,3]diazepines. The key step of the synthesis consists in a selective C-acylation of 2-amino-imidazo[1,2-a]pyrid...

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Veröffentlicht in:	Tetrahedron letters 2013-03, Vol.54 (11), p.1364-1367
Hauptverfasser:	Arama, Dominique P., Lisowski, Vincent, Scarlata, Eliana, Fulcrand, Pierre, Maillard, Ludovic T., Martinez, Jean, Masurier, Nicolas
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemical Sciences Diazepinones Friedel–Crafts acylation Imidazo[1,2-a]pyridine Polyfused heterocycles Urea derivatives
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container_title	Tetrahedron letters
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creator	Arama, Dominique P. Lisowski, Vincent Scarlata, Eliana Fulcrand, Pierre Maillard, Ludovic T. Martinez, Jean Masurier, Nicolas
description	We herein report the synthesis of a series of 12 optically pure 3,4-dihydro-1H-pyrido-[1′,2′:1,2]-imidazo[4,5-d][1,3]diazepine-2,5-diones, which form a new family of azaheterocycle-fused [1,3]diazepines. The key step of the synthesis consists in a selective C-acylation of 2-amino-imidazo[1,2-a]pyridine by various natural amino-acids, followed by an intracarbonylation reaction.
doi_str_mv	10.1016/j.tetlet.2012.12.087
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subjects	Chemical Sciences Diazepinones Friedel–Crafts acylation Imidazo[1,2-a]pyridine Polyfused heterocycles Urea derivatives
title	An efficient synthesis of pyrido-imidazodiazepinediones
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