Altered erythrocyte membrane fatty acid profile in typical Rett syndrome: Effects of omega-3 polyunsaturated fatty acid supplementation
Abstract This study mainly aims at examining the erythrocyte membrane fatty acid (FAs) profile in Rett syndrome (RTT), a genetically determined neurodevelopmental disease. Early reports suggest a beneficial effects of omega-3 polyunsaturated fatty acids (ω-3 PUFAs) on disease severity in RTT. A tota...
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| Veröffentlicht in: | Prostaglandins, leukotrienes and essential fatty acids leukotrienes and essential fatty acids, 2014-11, Vol.91 (5), p.183-193 |
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| creator | Signorini, Cinzia De Felice, Claudio Leoncini, Silvia Durand, Thierry Galano, Jean-Marie Cortelazzo, Alessio Zollo, Gloria Guerranti, Roberto Gonnelli, Stefano Caffarelli, Carla Rossi, Marcello Pecorelli, Alessandra Valacchi, Giuseppe Ciccoli, Lucia Hayek, Joussef |
| description | Abstract This study mainly aims at examining the erythrocyte membrane fatty acid (FAs) profile in Rett syndrome (RTT), a genetically determined neurodevelopmental disease. Early reports suggest a beneficial effects of omega-3 polyunsaturated fatty acids (ω-3 PUFAs) on disease severity in RTT. A total of 24 RTT patients were assigned to ω-3 PUFAs-containing fish oil for 12 months in a randomized controlled study (average DHA and EPA doses of 72.9, and 117.1 mg/kg b.w./day, respectively). A distinctly altered FAs profile was detectable in RTT, with deficient ω-6 PUFAs, increased saturated FAs and reduced trans 20:4 FAs. FAs changes were found to be related to redox imbalance, subclinical inflammation, and decreased bone density. Supplementation with ω-3 PUFAs led to improved ω-6/ω-3 ratio and serum plasma lipid profile, decreased PUFAs peroxidation end-products, normalization of biochemical markers of inflammation, and reduction of bone hypodensity as compared to the untreated RTT group. Our data indicate that a significant FAs abnormality is detectable in the RTT erythrocyte membranes and is partially rescued by ω-3 PUFAs. |
| doi_str_mv | 10.1016/j.plefa.2014.08.002 |
| format | Article |
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Early reports suggest a beneficial effects of omega-3 polyunsaturated fatty acids (ω-3 PUFAs) on disease severity in RTT. A total of 24 RTT patients were assigned to ω-3 PUFAs-containing fish oil for 12 months in a randomized controlled study (average DHA and EPA doses of 72.9, and 117.1 mg/kg b.w./day, respectively). A distinctly altered FAs profile was detectable in RTT, with deficient ω-6 PUFAs, increased saturated FAs and reduced trans 20:4 FAs. FAs changes were found to be related to redox imbalance, subclinical inflammation, and decreased bone density. Supplementation with ω-3 PUFAs led to improved ω-6/ω-3 ratio and serum plasma lipid profile, decreased PUFAs peroxidation end-products, normalization of biochemical markers of inflammation, and reduction of bone hypodensity as compared to the untreated RTT group. Our data indicate that a significant FAs abnormality is detectable in the RTT erythrocyte membranes and is partially rescued by ω-3 PUFAs.</description><identifier>ISSN: 0952-3278</identifier><identifier>EISSN: 1532-2823</identifier><identifier>DOI: 10.1016/j.plefa.2014.08.002</identifier><identifier>PMID: 25240461</identifier><language>eng</language><publisher>Scotland: Elsevier Ltd</publisher><subject>Adolescent ; Adult ; Advanced Basic Science ; Animals ; Biomarkers ; Biomarkers - blood ; Chemical Sciences ; Child ; Child, Preschool ; Dietary Supplements ; Docosahexaenoic Acids ; Docosahexaenoic Acids - administration & dosage ; Docosahexaenoic Acids - metabolism ; Eicosapentaenoic Acid ; Eicosapentaenoic Acid - administration & dosage ; Eicosapentaenoic Acid - metabolism ; Endocrinology & Metabolism ; Erythrocyte Membrane ; Erythrocyte Membrane - drug effects ; Erythrocyte Membrane - metabolism ; Erythrocyte Membrane - pathology ; Fatty Acids, Omega-3 ; Fatty Acids, Omega-3 - administration & dosage ; Fatty Acids, Omega-3 - metabolism ; Female ; Humans ; Inflammation ; Inflammation - metabolism ; Inflammation - pathology ; Isoprostanes ; Isoprostanes - blood ; Lipids ; Lipids - blood ; Omega-3 polyunsaturated fatty acids ; Rett Syndrome ; Rett Syndrome - diet therapy ; Rett Syndrome - metabolism ; Rett Syndrome - pathology</subject><ispartof>Prostaglandins, leukotrienes and essential fatty acids, 2014-11, Vol.91 (5), p.183-193</ispartof><rights>Elsevier Ltd</rights><rights>2014 Elsevier Ltd</rights><rights>Copyright © 2014 Elsevier Ltd. All rights reserved.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c448t-c5c4a4d166fec53d49316f3c79df65cc5c415b10862b38701b8c30b8e7ae95473</citedby><cites>FETCH-LOGICAL-c448t-c5c4a4d166fec53d49316f3c79df65cc5c415b10862b38701b8c30b8e7ae95473</cites><orcidid>0000-0003-1010-5255 ; 0000-0002-7027-1207 ; 0000-0003-3350-4857 ; 0000-0003-0006-9414 ; 0000-0002-9881-3119 ; 0000-0001-6086-7296 ; 0000-0001-6412-4967</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.plefa.2014.08.002$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25240461$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-03561176$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Signorini, Cinzia</creatorcontrib><creatorcontrib>De Felice, Claudio</creatorcontrib><creatorcontrib>Leoncini, Silvia</creatorcontrib><creatorcontrib>Durand, Thierry</creatorcontrib><creatorcontrib>Galano, Jean-Marie</creatorcontrib><creatorcontrib>Cortelazzo, Alessio</creatorcontrib><creatorcontrib>Zollo, Gloria</creatorcontrib><creatorcontrib>Guerranti, Roberto</creatorcontrib><creatorcontrib>Gonnelli, Stefano</creatorcontrib><creatorcontrib>Caffarelli, Carla</creatorcontrib><creatorcontrib>Rossi, Marcello</creatorcontrib><creatorcontrib>Pecorelli, Alessandra</creatorcontrib><creatorcontrib>Valacchi, Giuseppe</creatorcontrib><creatorcontrib>Ciccoli, Lucia</creatorcontrib><creatorcontrib>Hayek, Joussef</creatorcontrib><title>Altered erythrocyte membrane fatty acid profile in typical Rett syndrome: Effects of omega-3 polyunsaturated fatty acid supplementation</title><title>Prostaglandins, leukotrienes and essential fatty acids</title><addtitle>Prostaglandins Leukot Essent Fatty Acids</addtitle><description>Abstract This study mainly aims at examining the erythrocyte membrane fatty acid (FAs) profile in Rett syndrome (RTT), a genetically determined neurodevelopmental disease. Early reports suggest a beneficial effects of omega-3 polyunsaturated fatty acids (ω-3 PUFAs) on disease severity in RTT. A total of 24 RTT patients were assigned to ω-3 PUFAs-containing fish oil for 12 months in a randomized controlled study (average DHA and EPA doses of 72.9, and 117.1 mg/kg b.w./day, respectively). A distinctly altered FAs profile was detectable in RTT, with deficient ω-6 PUFAs, increased saturated FAs and reduced trans 20:4 FAs. FAs changes were found to be related to redox imbalance, subclinical inflammation, and decreased bone density. Supplementation with ω-3 PUFAs led to improved ω-6/ω-3 ratio and serum plasma lipid profile, decreased PUFAs peroxidation end-products, normalization of biochemical markers of inflammation, and reduction of bone hypodensity as compared to the untreated RTT group. Our data indicate that a significant FAs abnormality is detectable in the RTT erythrocyte membranes and is partially rescued by ω-3 PUFAs.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Advanced Basic Science</subject><subject>Animals</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Chemical Sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Dietary Supplements</subject><subject>Docosahexaenoic Acids</subject><subject>Docosahexaenoic Acids - administration & dosage</subject><subject>Docosahexaenoic Acids - metabolism</subject><subject>Eicosapentaenoic Acid</subject><subject>Eicosapentaenoic Acid - administration & dosage</subject><subject>Eicosapentaenoic Acid - metabolism</subject><subject>Endocrinology & Metabolism</subject><subject>Erythrocyte Membrane</subject><subject>Erythrocyte Membrane - drug effects</subject><subject>Erythrocyte Membrane - metabolism</subject><subject>Erythrocyte Membrane - pathology</subject><subject>Fatty Acids, Omega-3</subject><subject>Fatty Acids, Omega-3 - administration & dosage</subject><subject>Fatty Acids, Omega-3 - metabolism</subject><subject>Female</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Inflammation - metabolism</subject><subject>Inflammation - pathology</subject><subject>Isoprostanes</subject><subject>Isoprostanes - blood</subject><subject>Lipids</subject><subject>Lipids - blood</subject><subject>Omega-3 polyunsaturated fatty acids</subject><subject>Rett Syndrome</subject><subject>Rett Syndrome - diet therapy</subject><subject>Rett Syndrome - metabolism</subject><subject>Rett Syndrome - pathology</subject><issn>0952-3278</issn><issn>1532-2823</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkt2K1TAUhYsoznH0CQTJpV60Zifpn6BwGEZHOCD4A96FNN1xcmybmqQDfQJf29QzDuKNVyHJt_dK1tpZ9hRoARSql8diHtCoglEQBW0KStm9bAclZzlrGL-f7WhbspyzujnLHoVwpIkAEA-zM1YyQUUFu-znfojosSfo13jtnV4jkhHHzqsJiVExrkRp25PZO2MHJHYicZ2tVgP5iDGSsE69dyO-IpfGoI6BOEPS_pvKOZndsC5TUHHxKiaRv_qFZU7PH3GKKlo3Pc4eGDUEfHK7nmdf3l5-vrjKDx_evb_YH3ItRBNzXWqhRA9VlbRK3ouWQ2W4rtveVKXerqHsgDYV63hTU-gazWnXYK2wLUXNz7MXp77XapCzt6Pyq3TKyqv9QW5nlJcVQF3dQGKfn9j09x8LhihHGzQOQ7LGLUFCxdq2rlvGEspPqPYuBI_mrjdQuaUlj_J3WnJLS9JGpixS1bNbgaUbsb-r-RNPAl6fAEyW3Fj0MmiLk8be-uS17J39j8Cbf-r1YKctvO-4Yji6xU_JbQkyMEnlp21gtnkBQSmw9iv_BUbfvU8</recordid><startdate>20141101</startdate><enddate>20141101</enddate><creator>Signorini, Cinzia</creator><creator>De Felice, Claudio</creator><creator>Leoncini, Silvia</creator><creator>Durand, Thierry</creator><creator>Galano, Jean-Marie</creator><creator>Cortelazzo, Alessio</creator><creator>Zollo, Gloria</creator><creator>Guerranti, Roberto</creator><creator>Gonnelli, Stefano</creator><creator>Caffarelli, Carla</creator><creator>Rossi, Marcello</creator><creator>Pecorelli, Alessandra</creator><creator>Valacchi, Giuseppe</creator><creator>Ciccoli, Lucia</creator><creator>Hayek, Joussef</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0003-1010-5255</orcidid><orcidid>https://orcid.org/0000-0002-7027-1207</orcidid><orcidid>https://orcid.org/0000-0003-3350-4857</orcidid><orcidid>https://orcid.org/0000-0003-0006-9414</orcidid><orcidid>https://orcid.org/0000-0002-9881-3119</orcidid><orcidid>https://orcid.org/0000-0001-6086-7296</orcidid><orcidid>https://orcid.org/0000-0001-6412-4967</orcidid></search><sort><creationdate>20141101</creationdate><title>Altered erythrocyte membrane fatty acid profile in typical Rett syndrome: Effects of omega-3 polyunsaturated fatty acid supplementation</title><author>Signorini, Cinzia ; De Felice, Claudio ; Leoncini, Silvia ; Durand, Thierry ; Galano, Jean-Marie ; Cortelazzo, Alessio ; Zollo, Gloria ; Guerranti, Roberto ; Gonnelli, Stefano ; Caffarelli, Carla ; Rossi, Marcello ; Pecorelli, Alessandra ; Valacchi, Giuseppe ; Ciccoli, Lucia ; Hayek, Joussef</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c448t-c5c4a4d166fec53d49316f3c79df65cc5c415b10862b38701b8c30b8e7ae95473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Advanced Basic Science</topic><topic>Animals</topic><topic>Biomarkers</topic><topic>Biomarkers - blood</topic><topic>Chemical Sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Dietary Supplements</topic><topic>Docosahexaenoic Acids</topic><topic>Docosahexaenoic Acids - administration & dosage</topic><topic>Docosahexaenoic Acids - metabolism</topic><topic>Eicosapentaenoic Acid</topic><topic>Eicosapentaenoic Acid - administration & dosage</topic><topic>Eicosapentaenoic Acid - metabolism</topic><topic>Endocrinology & Metabolism</topic><topic>Erythrocyte Membrane</topic><topic>Erythrocyte Membrane - drug effects</topic><topic>Erythrocyte Membrane - metabolism</topic><topic>Erythrocyte Membrane - pathology</topic><topic>Fatty Acids, Omega-3</topic><topic>Fatty Acids, Omega-3 - administration & dosage</topic><topic>Fatty Acids, Omega-3 - metabolism</topic><topic>Female</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Inflammation - metabolism</topic><topic>Inflammation - pathology</topic><topic>Isoprostanes</topic><topic>Isoprostanes - blood</topic><topic>Lipids</topic><topic>Lipids - blood</topic><topic>Omega-3 polyunsaturated fatty acids</topic><topic>Rett Syndrome</topic><topic>Rett Syndrome - diet therapy</topic><topic>Rett Syndrome - metabolism</topic><topic>Rett Syndrome - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Signorini, Cinzia</creatorcontrib><creatorcontrib>De Felice, Claudio</creatorcontrib><creatorcontrib>Leoncini, Silvia</creatorcontrib><creatorcontrib>Durand, Thierry</creatorcontrib><creatorcontrib>Galano, Jean-Marie</creatorcontrib><creatorcontrib>Cortelazzo, Alessio</creatorcontrib><creatorcontrib>Zollo, Gloria</creatorcontrib><creatorcontrib>Guerranti, Roberto</creatorcontrib><creatorcontrib>Gonnelli, Stefano</creatorcontrib><creatorcontrib>Caffarelli, Carla</creatorcontrib><creatorcontrib>Rossi, Marcello</creatorcontrib><creatorcontrib>Pecorelli, Alessandra</creatorcontrib><creatorcontrib>Valacchi, Giuseppe</creatorcontrib><creatorcontrib>Ciccoli, Lucia</creatorcontrib><creatorcontrib>Hayek, Joussef</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Prostaglandins, leukotrienes and essential fatty acids</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Signorini, Cinzia</au><au>De Felice, Claudio</au><au>Leoncini, Silvia</au><au>Durand, Thierry</au><au>Galano, Jean-Marie</au><au>Cortelazzo, Alessio</au><au>Zollo, Gloria</au><au>Guerranti, Roberto</au><au>Gonnelli, Stefano</au><au>Caffarelli, Carla</au><au>Rossi, Marcello</au><au>Pecorelli, Alessandra</au><au>Valacchi, Giuseppe</au><au>Ciccoli, Lucia</au><au>Hayek, Joussef</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Altered erythrocyte membrane fatty acid profile in typical Rett syndrome: Effects of omega-3 polyunsaturated fatty acid supplementation</atitle><jtitle>Prostaglandins, leukotrienes and essential fatty acids</jtitle><addtitle>Prostaglandins Leukot Essent Fatty Acids</addtitle><date>2014-11-01</date><risdate>2014</risdate><volume>91</volume><issue>5</issue><spage>183</spage><epage>193</epage><pages>183-193</pages><issn>0952-3278</issn><eissn>1532-2823</eissn><abstract>Abstract This study mainly aims at examining the erythrocyte membrane fatty acid (FAs) profile in Rett syndrome (RTT), a genetically determined neurodevelopmental disease. Early reports suggest a beneficial effects of omega-3 polyunsaturated fatty acids (ω-3 PUFAs) on disease severity in RTT. A total of 24 RTT patients were assigned to ω-3 PUFAs-containing fish oil for 12 months in a randomized controlled study (average DHA and EPA doses of 72.9, and 117.1 mg/kg b.w./day, respectively). A distinctly altered FAs profile was detectable in RTT, with deficient ω-6 PUFAs, increased saturated FAs and reduced trans 20:4 FAs. FAs changes were found to be related to redox imbalance, subclinical inflammation, and decreased bone density. Supplementation with ω-3 PUFAs led to improved ω-6/ω-3 ratio and serum plasma lipid profile, decreased PUFAs peroxidation end-products, normalization of biochemical markers of inflammation, and reduction of bone hypodensity as compared to the untreated RTT group. Our data indicate that a significant FAs abnormality is detectable in the RTT erythrocyte membranes and is partially rescued by ω-3 PUFAs.</abstract><cop>Scotland</cop><pub>Elsevier Ltd</pub><pmid>25240461</pmid><doi>10.1016/j.plefa.2014.08.002</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0003-1010-5255</orcidid><orcidid>https://orcid.org/0000-0002-7027-1207</orcidid><orcidid>https://orcid.org/0000-0003-3350-4857</orcidid><orcidid>https://orcid.org/0000-0003-0006-9414</orcidid><orcidid>https://orcid.org/0000-0002-9881-3119</orcidid><orcidid>https://orcid.org/0000-0001-6086-7296</orcidid><orcidid>https://orcid.org/0000-0001-6412-4967</orcidid></addata></record> |
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| ispartof | Prostaglandins, leukotrienes and essential fatty acids, 2014-11, Vol.91 (5), p.183-193 |
| issn | 0952-3278 1532-2823 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Adolescent Adult Advanced Basic Science Animals Biomarkers Biomarkers - blood Chemical Sciences Child Child, Preschool Dietary Supplements Docosahexaenoic Acids Docosahexaenoic Acids - administration & dosage Docosahexaenoic Acids - metabolism Eicosapentaenoic Acid Eicosapentaenoic Acid - administration & dosage Eicosapentaenoic Acid - metabolism Endocrinology & Metabolism Erythrocyte Membrane Erythrocyte Membrane - drug effects Erythrocyte Membrane - metabolism Erythrocyte Membrane - pathology Fatty Acids, Omega-3 Fatty Acids, Omega-3 - administration & dosage Fatty Acids, Omega-3 - metabolism Female Humans Inflammation Inflammation - metabolism Inflammation - pathology Isoprostanes Isoprostanes - blood Lipids Lipids - blood Omega-3 polyunsaturated fatty acids Rett Syndrome Rett Syndrome - diet therapy Rett Syndrome - metabolism Rett Syndrome - pathology |
| title | Altered erythrocyte membrane fatty acid profile in typical Rett syndrome: Effects of omega-3 polyunsaturated fatty acid supplementation |
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