Effect of nasal airway nonlinearities on oscillometric resistance measurements in infants
Oscillometric measurements of respiratory system resistance (R ) in infants are usually made via the nasal pathways, which not only significantly contribute to overall R but also introduce marked flow (V')-dependent changes. We employed intrabreath oscillometry in casts of the upper airways con...
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| Veröffentlicht in: | Journal of applied physiology (1985) 2020-09, Vol.129 (3), p.591-598 |
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| creator | Radics, Bence L Makan, Gergely Coppens, Thibault André, Nicolas Page, Cyril Dégrugilliers, Loïc Bayat, S Kianoush Gingl, Zoltán Gyurkovits, Zita M Tóth, Tivadar Hantos, Zoltan Bayat, Sam |
| description | Oscillometric measurements of respiratory system resistance (R
) in infants are usually made via the nasal pathways, which not only significantly contribute to overall R
but also introduce marked flow (V')-dependent changes. We employed intrabreath oscillometry in casts of the upper airways constructed from head CT images of 46 infants. We examined oscillometric nasal resistance (R
) in upper airway casts with no respiratory flow (R
) and the effect of varying V' on R
by simulating tidal breathing. A characteristic nonlinear relationship was found between R
and V', exhibiting segmental linearity and a prominent breakpoint (V'
) after log-log transformation. V'
was linearly related to the preceding value of end-expiratory volume acceleration (V″
; on average
= 0.96,
< 0.001). R
depended on V', and R at end-expiration (R
) showed a strong dependence on V″
in every cast (
= 0.994,
< 001) with considerable interindividual variability. The intercept of the linear regression of R
versus V″
was found to be a close estimate of R
. These findings were utilized in reanalyzed R
data acquired in vivo in a small group of infants (
= 15). Using a graphical method to estimate R
from R
, we found a relative contribution of V'-dependent nonlinearity to total resistance of up to 33%. In conclusion, we propose a method for correcting the acceleration-dependent nonlinearity error in R
. This correction can be adapted to estimate R
from a single intrabreath oscillometric measurement, which would reduce the masking effects of the upper airways on the changes in the intrathoracic resistance.
Oscillometric measurements of respiratory system resistance (R
) in infants are usually made via the nasal pathways, which not only significantly contribute to overall R
but also introduce marked flow acceleration-dependent distortions. Here, we propose a method for correcting flow acceleration-dependent nonlinearity error based on in vitro measurements in 3D-printed upper airway casts of infants as well as in vivo measurements. This correction can be adapted to estimate R
from a single intrabreath oscillometric measurement. |
| doi_str_mv | 10.1152/japplphysiol.00128.2020 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_hal_03558215v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2427305641</sourcerecordid><originalsourceid>FETCH-LOGICAL-c424t-38201c837607ec19a79aa83f9a13ade8b3a8266fbdb7333d862ac5305c2b445c3</originalsourceid><addsrcrecordid>eNpdkU2LFDEQhoMou-O6f0EDXnYPPeaj08kcl2U_hAEvevAUqjPVbIZ00ibdyvx7M866iBCokHrqJcVDyAfO1pwr8WkP0xSmp0PxKawZ48KsBRPsFVnVrmh4x_hrsjJasUYro8_J21L2lWtbxc_IuRSaCdGZFfl-NwzoZpoGGqFAoODzLzjQmGLwESH72WOhKdJUnA8hjThn72jG4ssM0SEdEcqSccQ4F-pjPQPU6zvyZoBQ8PK5XpBv93dfbx-b7ZeHz7c328a1op0baQTjzkjdMY2Ob0BvAIwcNsAl7ND0EozouqHf9VpKuTOdAKckU070dRsnL8j1KfcJgp2yHyEfbAJvH2-29vjGpFJGcPWTV_bqxE45_ViwzHb0xWEIEDEtxYpW6BrdtUf043_oPi051k0q1badUdxsKqVPlMuplIzDyw84s0dT9l9T9o8pezRVJ98_5y_9iLuXub9q5G83FZK1</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2444685189</pqid></control><display><type>article</type><title>Effect of nasal airway nonlinearities on oscillometric resistance measurements in infants</title><source>American Physiological Society</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Radics, Bence L ; Makan, Gergely ; Coppens, Thibault ; André, Nicolas ; Page, Cyril ; Dégrugilliers, Loïc ; Bayat, S Kianoush ; Gingl, Zoltán ; Gyurkovits, Zita ; M Tóth, Tivadar ; Hantos, Zoltan ; Bayat, Sam</creator><creatorcontrib>Radics, Bence L ; Makan, Gergely ; Coppens, Thibault ; André, Nicolas ; Page, Cyril ; Dégrugilliers, Loïc ; Bayat, S Kianoush ; Gingl, Zoltán ; Gyurkovits, Zita ; M Tóth, Tivadar ; Hantos, Zoltan ; Bayat, Sam</creatorcontrib><description>Oscillometric measurements of respiratory system resistance (R
) in infants are usually made via the nasal pathways, which not only significantly contribute to overall R
but also introduce marked flow (V')-dependent changes. We employed intrabreath oscillometry in casts of the upper airways constructed from head CT images of 46 infants. We examined oscillometric nasal resistance (R
) in upper airway casts with no respiratory flow (R
) and the effect of varying V' on R
by simulating tidal breathing. A characteristic nonlinear relationship was found between R
and V', exhibiting segmental linearity and a prominent breakpoint (V'
) after log-log transformation. V'
was linearly related to the preceding value of end-expiratory volume acceleration (V″
; on average
= 0.96,
< 0.001). R
depended on V', and R at end-expiration (R
) showed a strong dependence on V″
in every cast (
= 0.994,
< 001) with considerable interindividual variability. The intercept of the linear regression of R
versus V″
was found to be a close estimate of R
. These findings were utilized in reanalyzed R
data acquired in vivo in a small group of infants (
= 15). Using a graphical method to estimate R
from R
, we found a relative contribution of V'-dependent nonlinearity to total resistance of up to 33%. In conclusion, we propose a method for correcting the acceleration-dependent nonlinearity error in R
. This correction can be adapted to estimate R
from a single intrabreath oscillometric measurement, which would reduce the masking effects of the upper airways on the changes in the intrathoracic resistance.
Oscillometric measurements of respiratory system resistance (R
) in infants are usually made via the nasal pathways, which not only significantly contribute to overall R
but also introduce marked flow acceleration-dependent distortions. Here, we propose a method for correcting flow acceleration-dependent nonlinearity error based on in vitro measurements in 3D-printed upper airway casts of infants as well as in vivo measurements. This correction can be adapted to estimate R
from a single intrabreath oscillometric measurement.</description><identifier>ISSN: 8750-7587</identifier><identifier>EISSN: 1522-1601</identifier><identifier>DOI: 10.1152/japplphysiol.00128.2020</identifier><identifier>PMID: 32702268</identifier><language>eng</language><publisher>United States: American Physiological Society</publisher><subject>Computed tomography ; Data acquisition ; Error correction ; Graphical methods ; Infants ; Life Sciences ; Linearity ; Masking ; Nonlinear systems ; Nonlinearity ; Respiratory system ; Respiratory tract</subject><ispartof>Journal of applied physiology (1985), 2020-09, Vol.129 (3), p.591-598</ispartof><rights>Copyright American Physiological Society Sep 2020</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c424t-38201c837607ec19a79aa83f9a13ade8b3a8266fbdb7333d862ac5305c2b445c3</citedby><cites>FETCH-LOGICAL-c424t-38201c837607ec19a79aa83f9a13ade8b3a8266fbdb7333d862ac5305c2b445c3</cites><orcidid>0000-0002-4623-7631 ; 0000-0002-4116-084X ; 0000-0002-8565-0293</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,3039,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32702268$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://u-picardie.hal.science/hal-03558215$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Radics, Bence L</creatorcontrib><creatorcontrib>Makan, Gergely</creatorcontrib><creatorcontrib>Coppens, Thibault</creatorcontrib><creatorcontrib>André, Nicolas</creatorcontrib><creatorcontrib>Page, Cyril</creatorcontrib><creatorcontrib>Dégrugilliers, Loïc</creatorcontrib><creatorcontrib>Bayat, S Kianoush</creatorcontrib><creatorcontrib>Gingl, Zoltán</creatorcontrib><creatorcontrib>Gyurkovits, Zita</creatorcontrib><creatorcontrib>M Tóth, Tivadar</creatorcontrib><creatorcontrib>Hantos, Zoltan</creatorcontrib><creatorcontrib>Bayat, Sam</creatorcontrib><title>Effect of nasal airway nonlinearities on oscillometric resistance measurements in infants</title><title>Journal of applied physiology (1985)</title><addtitle>J Appl Physiol (1985)</addtitle><description>Oscillometric measurements of respiratory system resistance (R
) in infants are usually made via the nasal pathways, which not only significantly contribute to overall R
but also introduce marked flow (V')-dependent changes. We employed intrabreath oscillometry in casts of the upper airways constructed from head CT images of 46 infants. We examined oscillometric nasal resistance (R
) in upper airway casts with no respiratory flow (R
) and the effect of varying V' on R
by simulating tidal breathing. A characteristic nonlinear relationship was found between R
and V', exhibiting segmental linearity and a prominent breakpoint (V'
) after log-log transformation. V'
was linearly related to the preceding value of end-expiratory volume acceleration (V″
; on average
= 0.96,
< 0.001). R
depended on V', and R at end-expiration (R
) showed a strong dependence on V″
in every cast (
= 0.994,
< 001) with considerable interindividual variability. The intercept of the linear regression of R
versus V″
was found to be a close estimate of R
. These findings were utilized in reanalyzed R
data acquired in vivo in a small group of infants (
= 15). Using a graphical method to estimate R
from R
, we found a relative contribution of V'-dependent nonlinearity to total resistance of up to 33%. In conclusion, we propose a method for correcting the acceleration-dependent nonlinearity error in R
. This correction can be adapted to estimate R
from a single intrabreath oscillometric measurement, which would reduce the masking effects of the upper airways on the changes in the intrathoracic resistance.
Oscillometric measurements of respiratory system resistance (R
) in infants are usually made via the nasal pathways, which not only significantly contribute to overall R
but also introduce marked flow acceleration-dependent distortions. Here, we propose a method for correcting flow acceleration-dependent nonlinearity error based on in vitro measurements in 3D-printed upper airway casts of infants as well as in vivo measurements. This correction can be adapted to estimate R
from a single intrabreath oscillometric measurement.</description><subject>Computed tomography</subject><subject>Data acquisition</subject><subject>Error correction</subject><subject>Graphical methods</subject><subject>Infants</subject><subject>Life Sciences</subject><subject>Linearity</subject><subject>Masking</subject><subject>Nonlinear systems</subject><subject>Nonlinearity</subject><subject>Respiratory system</subject><subject>Respiratory tract</subject><issn>8750-7587</issn><issn>1522-1601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNpdkU2LFDEQhoMou-O6f0EDXnYPPeaj08kcl2U_hAEvevAUqjPVbIZ00ibdyvx7M866iBCokHrqJcVDyAfO1pwr8WkP0xSmp0PxKawZ48KsBRPsFVnVrmh4x_hrsjJasUYro8_J21L2lWtbxc_IuRSaCdGZFfl-NwzoZpoGGqFAoODzLzjQmGLwESH72WOhKdJUnA8hjThn72jG4ssM0SEdEcqSccQ4F-pjPQPU6zvyZoBQ8PK5XpBv93dfbx-b7ZeHz7c328a1op0baQTjzkjdMY2Ob0BvAIwcNsAl7ND0EozouqHf9VpKuTOdAKckU070dRsnL8j1KfcJgp2yHyEfbAJvH2-29vjGpFJGcPWTV_bqxE45_ViwzHb0xWEIEDEtxYpW6BrdtUf043_oPi051k0q1badUdxsKqVPlMuplIzDyw84s0dT9l9T9o8pezRVJ98_5y_9iLuXub9q5G83FZK1</recordid><startdate>20200901</startdate><enddate>20200901</enddate><creator>Radics, Bence L</creator><creator>Makan, Gergely</creator><creator>Coppens, Thibault</creator><creator>André, Nicolas</creator><creator>Page, Cyril</creator><creator>Dégrugilliers, Loïc</creator><creator>Bayat, S Kianoush</creator><creator>Gingl, Zoltán</creator><creator>Gyurkovits, Zita</creator><creator>M Tóth, Tivadar</creator><creator>Hantos, Zoltan</creator><creator>Bayat, Sam</creator><general>American Physiological Society</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TS</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-4623-7631</orcidid><orcidid>https://orcid.org/0000-0002-4116-084X</orcidid><orcidid>https://orcid.org/0000-0002-8565-0293</orcidid></search><sort><creationdate>20200901</creationdate><title>Effect of nasal airway nonlinearities on oscillometric resistance measurements in infants</title><author>Radics, Bence L ; Makan, Gergely ; Coppens, Thibault ; André, Nicolas ; Page, Cyril ; Dégrugilliers, Loïc ; Bayat, S Kianoush ; Gingl, Zoltán ; Gyurkovits, Zita ; M Tóth, Tivadar ; Hantos, Zoltan ; Bayat, Sam</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c424t-38201c837607ec19a79aa83f9a13ade8b3a8266fbdb7333d862ac5305c2b445c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Computed tomography</topic><topic>Data acquisition</topic><topic>Error correction</topic><topic>Graphical methods</topic><topic>Infants</topic><topic>Life Sciences</topic><topic>Linearity</topic><topic>Masking</topic><topic>Nonlinear systems</topic><topic>Nonlinearity</topic><topic>Respiratory system</topic><topic>Respiratory tract</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Radics, Bence L</creatorcontrib><creatorcontrib>Makan, Gergely</creatorcontrib><creatorcontrib>Coppens, Thibault</creatorcontrib><creatorcontrib>André, Nicolas</creatorcontrib><creatorcontrib>Page, Cyril</creatorcontrib><creatorcontrib>Dégrugilliers, Loïc</creatorcontrib><creatorcontrib>Bayat, S Kianoush</creatorcontrib><creatorcontrib>Gingl, Zoltán</creatorcontrib><creatorcontrib>Gyurkovits, Zita</creatorcontrib><creatorcontrib>M Tóth, Tivadar</creatorcontrib><creatorcontrib>Hantos, Zoltan</creatorcontrib><creatorcontrib>Bayat, Sam</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Journal of applied physiology (1985)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Radics, Bence L</au><au>Makan, Gergely</au><au>Coppens, Thibault</au><au>André, Nicolas</au><au>Page, Cyril</au><au>Dégrugilliers, Loïc</au><au>Bayat, S Kianoush</au><au>Gingl, Zoltán</au><au>Gyurkovits, Zita</au><au>M Tóth, Tivadar</au><au>Hantos, Zoltan</au><au>Bayat, Sam</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of nasal airway nonlinearities on oscillometric resistance measurements in infants</atitle><jtitle>Journal of applied physiology (1985)</jtitle><addtitle>J Appl Physiol (1985)</addtitle><date>2020-09-01</date><risdate>2020</risdate><volume>129</volume><issue>3</issue><spage>591</spage><epage>598</epage><pages>591-598</pages><issn>8750-7587</issn><eissn>1522-1601</eissn><abstract>Oscillometric measurements of respiratory system resistance (R
) in infants are usually made via the nasal pathways, which not only significantly contribute to overall R
but also introduce marked flow (V')-dependent changes. We employed intrabreath oscillometry in casts of the upper airways constructed from head CT images of 46 infants. We examined oscillometric nasal resistance (R
) in upper airway casts with no respiratory flow (R
) and the effect of varying V' on R
by simulating tidal breathing. A characteristic nonlinear relationship was found between R
and V', exhibiting segmental linearity and a prominent breakpoint (V'
) after log-log transformation. V'
was linearly related to the preceding value of end-expiratory volume acceleration (V″
; on average
= 0.96,
< 0.001). R
depended on V', and R at end-expiration (R
) showed a strong dependence on V″
in every cast (
= 0.994,
< 001) with considerable interindividual variability. The intercept of the linear regression of R
versus V″
was found to be a close estimate of R
. These findings were utilized in reanalyzed R
data acquired in vivo in a small group of infants (
= 15). Using a graphical method to estimate R
from R
, we found a relative contribution of V'-dependent nonlinearity to total resistance of up to 33%. In conclusion, we propose a method for correcting the acceleration-dependent nonlinearity error in R
. This correction can be adapted to estimate R
from a single intrabreath oscillometric measurement, which would reduce the masking effects of the upper airways on the changes in the intrathoracic resistance.
Oscillometric measurements of respiratory system resistance (R
) in infants are usually made via the nasal pathways, which not only significantly contribute to overall R
but also introduce marked flow acceleration-dependent distortions. Here, we propose a method for correcting flow acceleration-dependent nonlinearity error based on in vitro measurements in 3D-printed upper airway casts of infants as well as in vivo measurements. This correction can be adapted to estimate R
from a single intrabreath oscillometric measurement.</abstract><cop>United States</cop><pub>American Physiological Society</pub><pmid>32702268</pmid><doi>10.1152/japplphysiol.00128.2020</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-4623-7631</orcidid><orcidid>https://orcid.org/0000-0002-4116-084X</orcidid><orcidid>https://orcid.org/0000-0002-8565-0293</orcidid><oa>free_for_read</oa></addata></record> |
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| source | American Physiological Society; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Computed tomography Data acquisition Error correction Graphical methods Infants Life Sciences Linearity Masking Nonlinear systems Nonlinearity Respiratory system Respiratory tract |
| title | Effect of nasal airway nonlinearities on oscillometric resistance measurements in infants |
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