Association between childhood maltreatment and the clinical course of bipolar disorders: A survival analysis of mood recurrences
Objectives Childhood maltreatment, also referred as childhood trauma, increases the severity of bipolar disorders (BD). Childhood maltreatment has been associated with more frequent mood recurrences, however, mostly in retrospective studies. Since scarce, further prospective studies are required to...
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| Veröffentlicht in: | Acta psychiatrica Scandinavica 2022-04, Vol.145 (4), p.373-383 |
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| creator | Grillault Laroche, Diane Godin, Ophélia Belzeaux, Raoul M’Bailara, Katia Loftus, Joséphine Courtet, Philippe Dubertret, Caroline Haffen, Emmanuel Llorca, Pierre Michel Olie, Emilie Passerieux, Christine Polosan, Mircea Schwan, Raymund Leboyer, Marion Bellivier, Frank Marie‐Claire, Cynthia Etain, Bruno |
| description | Objectives
Childhood maltreatment, also referred as childhood trauma, increases the severity of bipolar disorders (BD). Childhood maltreatment has been associated with more frequent mood recurrences, however, mostly in retrospective studies. Since scarce, further prospective studies are required to identify whether childhood maltreatment may be associated with the time to recurrence in BD.
Methods
Individuals with BD (N = 2008) were assessed clinically and for childhood maltreatment at baseline, and followed up for two years. The cumulative probability of mood recurrence over time was estimated with the Turnbull’s extension of the Kaplan–Meier analysis for interval‐censored data, including childhood maltreatment as a whole, and then maltreatment subtypes as predictors. Analyses were adjusted for potential confounding factors.
Results
The median duration of follow‐up was 22.3 months (IQR:12.0–24.8). Univariable analyses showed associations between childhood maltreatment, in particular all types of abuses (emotional, physical, and sexual) or emotional neglect, and a shorter time to recurrence (all p |
| doi_str_mv | 10.1111/acps.13401 |
| format | Article |
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Childhood maltreatment, also referred as childhood trauma, increases the severity of bipolar disorders (BD). Childhood maltreatment has been associated with more frequent mood recurrences, however, mostly in retrospective studies. Since scarce, further prospective studies are required to identify whether childhood maltreatment may be associated with the time to recurrence in BD.
Methods
Individuals with BD (N = 2008) were assessed clinically and for childhood maltreatment at baseline, and followed up for two years. The cumulative probability of mood recurrence over time was estimated with the Turnbull’s extension of the Kaplan–Meier analysis for interval‐censored data, including childhood maltreatment as a whole, and then maltreatment subtypes as predictors. Analyses were adjusted for potential confounding factors.
Results
The median duration of follow‐up was 22.3 months (IQR:12.0–24.8). Univariable analyses showed associations between childhood maltreatment, in particular all types of abuses (emotional, physical, and sexual) or emotional neglect, and a shorter time to recurrence (all p < 0.001). When including potential confounders into the multivariable models, the time to mood recurrence was associated with multiple/severe childhood maltreatment (i.e., total score above the 75th percentile) (HR = 1.32 95%CI (1.11–1.57), p = 0.002), and more specifically with moderate/severe physical abuse (HR = 1.44 95%CI(1.21–1.73), p < 0.0001). Living alone, lifetime anxiety disorders, lifetime number of mood episodes, baseline depressive and (hypo)manic symptoms, and baseline use of atypical antipsychotics were also associated with the time to recurrence.
Conclusions
In addition to typical predictors of mood recurrences, an exposure to multiple/severe forms of childhood maltreatment, and more specifically to moderate to severe physical abuse, may increase the risk for a mood recurrence in BD. This leads to the recommendations of more scrutiny and denser follow‐up of the individuals having been exposed to such early‐life stressors.</description><identifier>ISSN: 0001-690X</identifier><identifier>EISSN: 1600-0447</identifier><identifier>DOI: 10.1111/acps.13401</identifier><identifier>PMID: 35080248</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Abuse ; Antipsychotics ; Anxiety disorders ; Bipolar disorder ; Bipolar Disorder - psychology ; Child ; Child Abuse - psychology ; Childhood ; childhood maltreatment ; childhood trauma ; Children ; Emotions ; Human health and pathology ; Humans ; Life Sciences ; Mood ; mood recurrence ; Neurons and Cognition ; physical abuse ; Recurrence ; Retrospective Studies ; Surveys and Questionnaires ; Survival Analysis ; Trauma</subject><ispartof>Acta psychiatrica Scandinavica, 2022-04, Vol.145 (4), p.373-383</ispartof><rights>2022 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><rights>2022 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>Copyright</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3911-6d10e2bb91a66b3517339dfaedb1c8d06fa9782d07412fafd8ac8bf5c1b255043</citedby><cites>FETCH-LOGICAL-c3911-6d10e2bb91a66b3517339dfaedb1c8d06fa9782d07412fafd8ac8bf5c1b255043</cites><orcidid>0000-0002-5377-1488 ; 0000-0002-6519-8586 ; 0000-0001-5004-5475 ; 0000-0001-5473-3697 ; 0000-0001-7438-8990 ; 0000-0003-4130-1590</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Facps.13401$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Facps.13401$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35080248$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-03554884$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Grillault Laroche, Diane</creatorcontrib><creatorcontrib>Godin, Ophélia</creatorcontrib><creatorcontrib>Belzeaux, Raoul</creatorcontrib><creatorcontrib>M’Bailara, Katia</creatorcontrib><creatorcontrib>Loftus, Joséphine</creatorcontrib><creatorcontrib>Courtet, Philippe</creatorcontrib><creatorcontrib>Dubertret, Caroline</creatorcontrib><creatorcontrib>Haffen, Emmanuel</creatorcontrib><creatorcontrib>Llorca, Pierre Michel</creatorcontrib><creatorcontrib>Olie, Emilie</creatorcontrib><creatorcontrib>Passerieux, Christine</creatorcontrib><creatorcontrib>Polosan, Mircea</creatorcontrib><creatorcontrib>Schwan, Raymund</creatorcontrib><creatorcontrib>Leboyer, Marion</creatorcontrib><creatorcontrib>Bellivier, Frank</creatorcontrib><creatorcontrib>Marie‐Claire, Cynthia</creatorcontrib><creatorcontrib>Etain, Bruno</creatorcontrib><creatorcontrib>FACE-BD collaborators</creatorcontrib><creatorcontrib>The FACE‐BD collaborators</creatorcontrib><title>Association between childhood maltreatment and the clinical course of bipolar disorders: A survival analysis of mood recurrences</title><title>Acta psychiatrica Scandinavica</title><addtitle>Acta Psychiatr Scand</addtitle><description>Objectives
Childhood maltreatment, also referred as childhood trauma, increases the severity of bipolar disorders (BD). Childhood maltreatment has been associated with more frequent mood recurrences, however, mostly in retrospective studies. Since scarce, further prospective studies are required to identify whether childhood maltreatment may be associated with the time to recurrence in BD.
Methods
Individuals with BD (N = 2008) were assessed clinically and for childhood maltreatment at baseline, and followed up for two years. The cumulative probability of mood recurrence over time was estimated with the Turnbull’s extension of the Kaplan–Meier analysis for interval‐censored data, including childhood maltreatment as a whole, and then maltreatment subtypes as predictors. Analyses were adjusted for potential confounding factors.
Results
The median duration of follow‐up was 22.3 months (IQR:12.0–24.8). Univariable analyses showed associations between childhood maltreatment, in particular all types of abuses (emotional, physical, and sexual) or emotional neglect, and a shorter time to recurrence (all p < 0.001). When including potential confounders into the multivariable models, the time to mood recurrence was associated with multiple/severe childhood maltreatment (i.e., total score above the 75th percentile) (HR = 1.32 95%CI (1.11–1.57), p = 0.002), and more specifically with moderate/severe physical abuse (HR = 1.44 95%CI(1.21–1.73), p < 0.0001). Living alone, lifetime anxiety disorders, lifetime number of mood episodes, baseline depressive and (hypo)manic symptoms, and baseline use of atypical antipsychotics were also associated with the time to recurrence.
Conclusions
In addition to typical predictors of mood recurrences, an exposure to multiple/severe forms of childhood maltreatment, and more specifically to moderate to severe physical abuse, may increase the risk for a mood recurrence in BD. This leads to the recommendations of more scrutiny and denser follow‐up of the individuals having been exposed to such early‐life stressors.</description><subject>Abuse</subject><subject>Antipsychotics</subject><subject>Anxiety disorders</subject><subject>Bipolar disorder</subject><subject>Bipolar Disorder - psychology</subject><subject>Child</subject><subject>Child Abuse - psychology</subject><subject>Childhood</subject><subject>childhood maltreatment</subject><subject>childhood trauma</subject><subject>Children</subject><subject>Emotions</subject><subject>Human health and pathology</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Mood</subject><subject>mood recurrence</subject><subject>Neurons and Cognition</subject><subject>physical abuse</subject><subject>Recurrence</subject><subject>Retrospective Studies</subject><subject>Surveys and Questionnaires</subject><subject>Survival Analysis</subject><subject>Trauma</subject><issn>0001-690X</issn><issn>1600-0447</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90c9rFDEUB_Agit1WL_4BEvBiC1uTzK9Mb8NiW2FBQQVv4U3yhk3JTNZkZsve_NPNdNoePJgcQsKHb_LyCHnH2SVP4xPofbzkWc74C7LiJWNrlufVS7JijPF1WbNfJ-Q0xru0LTiTr8lJVjDJRC5X5E8To9cWRusH2uJ4jzhQvbPO7Lw3tAc3BoSxx2GkMBg67pBqZwerwVHtpxCR-o62du8dBGps9MFgiFe0oXEKB3tIDgZwx2jjLPs5NqCeQsBBY3xDXnXgIr59XM_Iz-vPPza36-3Xmy-bZrvWWc1TFYYzFG1bcyjLNit4lWW16QBNy7U0rOygrqQwrMq56KAzErRsu0LzVhQFy7Mzcr7k7sCpfbA9hKPyYNVts1XzGcuKIpcyP_BkPy52H_zvCeOoehs1OgcD-ikqUQpRFzWTItEP_9C79Cmp3lllVZri4fKLRengYwzYPb-AMzX3UM09VA89TPj9Y-TU9mie6VPTEuALuLcOj_-JUs3m2_cl9C8Q0ae0</recordid><startdate>202204</startdate><enddate>202204</enddate><creator>Grillault Laroche, Diane</creator><creator>Godin, Ophélia</creator><creator>Belzeaux, Raoul</creator><creator>M’Bailara, Katia</creator><creator>Loftus, Joséphine</creator><creator>Courtet, Philippe</creator><creator>Dubertret, Caroline</creator><creator>Haffen, Emmanuel</creator><creator>Llorca, Pierre Michel</creator><creator>Olie, Emilie</creator><creator>Passerieux, Christine</creator><creator>Polosan, Mircea</creator><creator>Schwan, Raymund</creator><creator>Leboyer, Marion</creator><creator>Bellivier, Frank</creator><creator>Marie‐Claire, Cynthia</creator><creator>Etain, Bruno</creator><general>Blackwell Publishing Ltd</general><general>Wiley</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-5377-1488</orcidid><orcidid>https://orcid.org/0000-0002-6519-8586</orcidid><orcidid>https://orcid.org/0000-0001-5004-5475</orcidid><orcidid>https://orcid.org/0000-0001-5473-3697</orcidid><orcidid>https://orcid.org/0000-0001-7438-8990</orcidid><orcidid>https://orcid.org/0000-0003-4130-1590</orcidid></search><sort><creationdate>202204</creationdate><title>Association between childhood maltreatment and the clinical course of bipolar disorders: A survival analysis of mood recurrences</title><author>Grillault Laroche, Diane ; Godin, Ophélia ; Belzeaux, Raoul ; M’Bailara, Katia ; Loftus, Joséphine ; Courtet, Philippe ; Dubertret, Caroline ; Haffen, Emmanuel ; Llorca, Pierre Michel ; Olie, Emilie ; Passerieux, Christine ; Polosan, Mircea ; Schwan, Raymund ; Leboyer, Marion ; Bellivier, Frank ; Marie‐Claire, Cynthia ; Etain, Bruno</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3911-6d10e2bb91a66b3517339dfaedb1c8d06fa9782d07412fafd8ac8bf5c1b255043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Abuse</topic><topic>Antipsychotics</topic><topic>Anxiety disorders</topic><topic>Bipolar disorder</topic><topic>Bipolar Disorder - psychology</topic><topic>Child</topic><topic>Child Abuse - psychology</topic><topic>Childhood</topic><topic>childhood maltreatment</topic><topic>childhood trauma</topic><topic>Children</topic><topic>Emotions</topic><topic>Human health and pathology</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Mood</topic><topic>mood recurrence</topic><topic>Neurons and Cognition</topic><topic>physical abuse</topic><topic>Recurrence</topic><topic>Retrospective Studies</topic><topic>Surveys and Questionnaires</topic><topic>Survival Analysis</topic><topic>Trauma</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Grillault Laroche, Diane</creatorcontrib><creatorcontrib>Godin, Ophélia</creatorcontrib><creatorcontrib>Belzeaux, Raoul</creatorcontrib><creatorcontrib>M’Bailara, Katia</creatorcontrib><creatorcontrib>Loftus, Joséphine</creatorcontrib><creatorcontrib>Courtet, Philippe</creatorcontrib><creatorcontrib>Dubertret, Caroline</creatorcontrib><creatorcontrib>Haffen, Emmanuel</creatorcontrib><creatorcontrib>Llorca, Pierre Michel</creatorcontrib><creatorcontrib>Olie, Emilie</creatorcontrib><creatorcontrib>Passerieux, Christine</creatorcontrib><creatorcontrib>Polosan, Mircea</creatorcontrib><creatorcontrib>Schwan, Raymund</creatorcontrib><creatorcontrib>Leboyer, Marion</creatorcontrib><creatorcontrib>Bellivier, Frank</creatorcontrib><creatorcontrib>Marie‐Claire, Cynthia</creatorcontrib><creatorcontrib>Etain, Bruno</creatorcontrib><creatorcontrib>FACE-BD collaborators</creatorcontrib><creatorcontrib>The FACE‐BD collaborators</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Acta psychiatrica Scandinavica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Grillault Laroche, Diane</au><au>Godin, Ophélia</au><au>Belzeaux, Raoul</au><au>M’Bailara, Katia</au><au>Loftus, Joséphine</au><au>Courtet, Philippe</au><au>Dubertret, Caroline</au><au>Haffen, Emmanuel</au><au>Llorca, Pierre Michel</au><au>Olie, Emilie</au><au>Passerieux, Christine</au><au>Polosan, Mircea</au><au>Schwan, Raymund</au><au>Leboyer, Marion</au><au>Bellivier, Frank</au><au>Marie‐Claire, Cynthia</au><au>Etain, Bruno</au><aucorp>FACE-BD collaborators</aucorp><aucorp>The FACE‐BD collaborators</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between childhood maltreatment and the clinical course of bipolar disorders: A survival analysis of mood recurrences</atitle><jtitle>Acta psychiatrica Scandinavica</jtitle><addtitle>Acta Psychiatr Scand</addtitle><date>2022-04</date><risdate>2022</risdate><volume>145</volume><issue>4</issue><spage>373</spage><epage>383</epage><pages>373-383</pages><issn>0001-690X</issn><eissn>1600-0447</eissn><abstract>Objectives
Childhood maltreatment, also referred as childhood trauma, increases the severity of bipolar disorders (BD). Childhood maltreatment has been associated with more frequent mood recurrences, however, mostly in retrospective studies. Since scarce, further prospective studies are required to identify whether childhood maltreatment may be associated with the time to recurrence in BD.
Methods
Individuals with BD (N = 2008) were assessed clinically and for childhood maltreatment at baseline, and followed up for two years. The cumulative probability of mood recurrence over time was estimated with the Turnbull’s extension of the Kaplan–Meier analysis for interval‐censored data, including childhood maltreatment as a whole, and then maltreatment subtypes as predictors. Analyses were adjusted for potential confounding factors.
Results
The median duration of follow‐up was 22.3 months (IQR:12.0–24.8). Univariable analyses showed associations between childhood maltreatment, in particular all types of abuses (emotional, physical, and sexual) or emotional neglect, and a shorter time to recurrence (all p < 0.001). When including potential confounders into the multivariable models, the time to mood recurrence was associated with multiple/severe childhood maltreatment (i.e., total score above the 75th percentile) (HR = 1.32 95%CI (1.11–1.57), p = 0.002), and more specifically with moderate/severe physical abuse (HR = 1.44 95%CI(1.21–1.73), p < 0.0001). Living alone, lifetime anxiety disorders, lifetime number of mood episodes, baseline depressive and (hypo)manic symptoms, and baseline use of atypical antipsychotics were also associated with the time to recurrence.
Conclusions
In addition to typical predictors of mood recurrences, an exposure to multiple/severe forms of childhood maltreatment, and more specifically to moderate to severe physical abuse, may increase the risk for a mood recurrence in BD. This leads to the recommendations of more scrutiny and denser follow‐up of the individuals having been exposed to such early‐life stressors.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>35080248</pmid><doi>10.1111/acps.13401</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-5377-1488</orcidid><orcidid>https://orcid.org/0000-0002-6519-8586</orcidid><orcidid>https://orcid.org/0000-0001-5004-5475</orcidid><orcidid>https://orcid.org/0000-0001-5473-3697</orcidid><orcidid>https://orcid.org/0000-0001-7438-8990</orcidid><orcidid>https://orcid.org/0000-0003-4130-1590</orcidid></addata></record> |
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| ispartof | Acta psychiatrica Scandinavica, 2022-04, Vol.145 (4), p.373-383 |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Abuse Antipsychotics Anxiety disorders Bipolar disorder Bipolar Disorder - psychology Child Child Abuse - psychology Childhood childhood maltreatment childhood trauma Children Emotions Human health and pathology Humans Life Sciences Mood mood recurrence Neurons and Cognition physical abuse Recurrence Retrospective Studies Surveys and Questionnaires Survival Analysis Trauma |
| title | Association between childhood maltreatment and the clinical course of bipolar disorders: A survival analysis of mood recurrences |
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