Handedness in bipolar disorders is associated with specific neurodevelopmental features: results of the BD-FACE cohort
Objectives High rates of non-right-handedness (NRH) and mixed-handedness exist in neurodevelopmental disorders. Dysfunctional neurodevelopmental pathways may be implicated in the underlying pathophysiology of bipolar disorders (BD), at least in some subgroups. Yet little is known about correlates of...
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| Veröffentlicht in: | European archives of psychiatry and clinical neuroscience 2022-08, Vol.272 (5), p.827-838 |
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| creator | Mallet, Jasmina Godin, Ophélia Mazer, Nicolas Le Strat, Yann Bellivier, Frank Belzeaux, Raoul Etain, Bruno Fond, Guillaume Gard, Sébastien Henry, Chantal Leboyer, Marion Llorca, Pierre-Michel Loftus, Joséphine Olié, Emilie Passerieux, Christine Polosan, Mircea Schwan, Raymund Roux, Paul Dubertret, Caroline |
| description | Objectives
High rates of non-right-handedness (NRH) and mixed-handedness exist in neurodevelopmental disorders. Dysfunctional neurodevelopmental pathways may be implicated in the underlying pathophysiology of bipolar disorders (BD), at least in some subgroups. Yet little is known about correlates of NRH and mixed-handedness in BD. The objectives of this national study are to determine (i) the prevalence of NRH and mixed-handedness in a well-stabilized sample of BD individuals; (ii) if NRH/mixed-handedness in BD is associated with a different clinical, biological and neurocognitive profile.
Methods
We included 2174 stabilized individuals. Participants were tested with a comprehensive battery of neuropsychological tests. Handedness was assessed using a single oral question. Learning and/or language disorders and obstetrical complications were recorded using childhood records. Common environmental, clinical and biological parameters were assessed.
Results
The prevalence of NRH and mixed-handedness were, respectively, 11.6 and 2.4%. Learning/language disorders were found in 9.7% out of the total sample and were associated with atypical handedness (only dyslexia for mixed-handedness (
p
|
| doi_str_mv | 10.1007/s00406-021-01314-3 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_hal_03553967v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A710173372</galeid><sourcerecordid>A710173372</sourcerecordid><originalsourceid>FETCH-LOGICAL-c453t-c0d78f18df5ec84cb56788edc7f634cefacf7d8172b5e12b59ab990bc9f82ae63</originalsourceid><addsrcrecordid>eNp9kUGLFDEQhRtR3HH1D3gKePLQa6WT7qS9jeOuIwx40XNIJ5WdLD2dNknP4r83a4uLIFJQBY_vFQ9eVb2mcEUBxLsEwKGroaE1UEZ5zZ5UG8oZqyXv6dNqAz2HmjLGL6oXKd0BAG0beF5dMM4El7zZVOe9nizaCVMifiKDn8OoI7E-hWgxFjERnVIwXme05N7nI0kzGu-8IRMuMVg84xjmE05Zj8ShzkvE9J6UtYw5keBIPiL58LG-2e6uiQnHEPPL6pnTY8JXv-9l9e3m-utuXx--fPq82x5qw1uWawNWSEeldS0ayc3QdkJKtEa4jnGDThsnrKSiGVqkZfV66HsYTO9ko7Fjl9Xb9e9Rj2qO_qTjDxW0V_vtQT1owNqW9Z0408K-Wdk5hu8LpqzuwhKnEk81nZRC0L6BR-pWj6j85EKO2px8MmorKFDBmGgKdfUPqozFkzdhQueL_pehWQ0mhpQiuj9pKaiHttXatiptq19tK1ZMbDWlAk-3GB8T_8f1E-8LqoU</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2688771920</pqid></control><display><type>article</type><title>Handedness in bipolar disorders is associated with specific neurodevelopmental features: results of the BD-FACE cohort</title><source>SpringerLink Journals</source><creator>Mallet, Jasmina ; Godin, Ophélia ; Mazer, Nicolas ; Le Strat, Yann ; Bellivier, Frank ; Belzeaux, Raoul ; Etain, Bruno ; Fond, Guillaume ; Gard, Sébastien ; Henry, Chantal ; Leboyer, Marion ; Llorca, Pierre-Michel ; Loftus, Joséphine ; Olié, Emilie ; Passerieux, Christine ; Polosan, Mircea ; Schwan, Raymund ; Roux, Paul ; Dubertret, Caroline</creator><creatorcontrib>Mallet, Jasmina ; Godin, Ophélia ; Mazer, Nicolas ; Le Strat, Yann ; Bellivier, Frank ; Belzeaux, Raoul ; Etain, Bruno ; Fond, Guillaume ; Gard, Sébastien ; Henry, Chantal ; Leboyer, Marion ; Llorca, Pierre-Michel ; Loftus, Joséphine ; Olié, Emilie ; Passerieux, Christine ; Polosan, Mircea ; Schwan, Raymund ; Roux, Paul ; Dubertret, Caroline ; the FACE-BD (FondaMental Academic Centers of Expertise for Bipolar Disorder) Group</creatorcontrib><description>Objectives
High rates of non-right-handedness (NRH) and mixed-handedness exist in neurodevelopmental disorders. Dysfunctional neurodevelopmental pathways may be implicated in the underlying pathophysiology of bipolar disorders (BD), at least in some subgroups. Yet little is known about correlates of NRH and mixed-handedness in BD. The objectives of this national study are to determine (i) the prevalence of NRH and mixed-handedness in a well-stabilized sample of BD individuals; (ii) if NRH/mixed-handedness in BD is associated with a different clinical, biological and neurocognitive profile.
Methods
We included 2174 stabilized individuals. Participants were tested with a comprehensive battery of neuropsychological tests. Handedness was assessed using a single oral question. Learning and/or language disorders and obstetrical complications were recorded using childhood records. Common environmental, clinical and biological parameters were assessed.
Results
The prevalence of NRH and mixed-handedness were, respectively, 11.6 and 2.4%. Learning/language disorders were found in 9.7% out of the total sample and were associated with atypical handedness (only dyslexia for mixed-handedness (
p
< 0.01), and dyslexia and dysphasia for NRH (
p
= 0.01 and
p
= 0.04, respectively). In multivariate analyses, NRH was associated with a younger age of BD onset (aOR 0.98 (95% CI 0.96–0.99) and lifetime substance use disorder (aOR 1.40 (95% CI 1.03–1.82) but not with any of the cognitive subtasks. Mixed-handedness was associated in univariate analyses with lifetime substance use disorder, lifetime cannabis use disorder (all
p
< 0.01) and less mood stabilizer prescription (
p
= 0.028). No association was found between NRH or mixed-handedness and the following parameters: trauma history, obstetrical complications, prior psychotic symptoms, bipolar subtype, attention deficit/hyperactivity disorder, peripheral inflammation or body mass index.
Conclusions
Handedness may be associated with specific features in BD, possibly reflecting a specific subgroup with a neurodevelopmental load.</description><identifier>ISSN: 0940-1334</identifier><identifier>EISSN: 1433-8491</identifier><identifier>DOI: 10.1007/s00406-021-01314-3</identifier><identifier>PMID: 34374842</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Analysis ; Antidepressants ; Attention deficit hyperactivity disorder ; Batteries ; Bipolar disorder ; Body mass index ; Cannabis ; Children ; Cognition ; Cognitive ability ; Cognitive science ; Drug use ; Dyslexia ; Handedness ; Human health and pathology ; Language ; Language disorders ; Life Sciences ; Medicine ; Medicine & Public Health ; Neurodevelopmental disorders ; Neuroscience ; Neurosciences ; Original Paper ; Psychiatrics and mental health ; Psychiatry ; Substance use ; Trauma</subject><ispartof>European archives of psychiatry and clinical neuroscience, 2022-08, Vol.272 (5), p.827-838</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2021</rights><rights>COPYRIGHT 2022 Springer</rights><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2021.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c453t-c0d78f18df5ec84cb56788edc7f634cefacf7d8172b5e12b59ab990bc9f82ae63</citedby><cites>FETCH-LOGICAL-c453t-c0d78f18df5ec84cb56788edc7f634cefacf7d8172b5e12b59ab990bc9f82ae63</cites><orcidid>0000-0001-5050-1362 ; 0000-0003-4130-1590 ; 0000-0002-1059-5584 ; 0000-0002-3660-6640 ; 0000-0001-7438-8990 ; 0000-0002-3985-4885 ; 0000-0002-5377-1488 ; 0000-0002-6519-8586 ; 0000-0003-3249-2030 ; 0000-0003-0321-4189 ; 0000-0003-1222-6050 ; 0000-0001-5004-5475 ; 0000-0001-5473-3697 ; 0000-0002-4907-8568</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00406-021-01314-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00406-021-01314-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://uca.hal.science/hal-03553967$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Mallet, Jasmina</creatorcontrib><creatorcontrib>Godin, Ophélia</creatorcontrib><creatorcontrib>Mazer, Nicolas</creatorcontrib><creatorcontrib>Le Strat, Yann</creatorcontrib><creatorcontrib>Bellivier, Frank</creatorcontrib><creatorcontrib>Belzeaux, Raoul</creatorcontrib><creatorcontrib>Etain, Bruno</creatorcontrib><creatorcontrib>Fond, Guillaume</creatorcontrib><creatorcontrib>Gard, Sébastien</creatorcontrib><creatorcontrib>Henry, Chantal</creatorcontrib><creatorcontrib>Leboyer, Marion</creatorcontrib><creatorcontrib>Llorca, Pierre-Michel</creatorcontrib><creatorcontrib>Loftus, Joséphine</creatorcontrib><creatorcontrib>Olié, Emilie</creatorcontrib><creatorcontrib>Passerieux, Christine</creatorcontrib><creatorcontrib>Polosan, Mircea</creatorcontrib><creatorcontrib>Schwan, Raymund</creatorcontrib><creatorcontrib>Roux, Paul</creatorcontrib><creatorcontrib>Dubertret, Caroline</creatorcontrib><creatorcontrib>the FACE-BD (FondaMental Academic Centers of Expertise for Bipolar Disorder) Group</creatorcontrib><title>Handedness in bipolar disorders is associated with specific neurodevelopmental features: results of the BD-FACE cohort</title><title>European archives of psychiatry and clinical neuroscience</title><addtitle>Eur Arch Psychiatry Clin Neurosci</addtitle><description>Objectives
High rates of non-right-handedness (NRH) and mixed-handedness exist in neurodevelopmental disorders. Dysfunctional neurodevelopmental pathways may be implicated in the underlying pathophysiology of bipolar disorders (BD), at least in some subgroups. Yet little is known about correlates of NRH and mixed-handedness in BD. The objectives of this national study are to determine (i) the prevalence of NRH and mixed-handedness in a well-stabilized sample of BD individuals; (ii) if NRH/mixed-handedness in BD is associated with a different clinical, biological and neurocognitive profile.
Methods
We included 2174 stabilized individuals. Participants were tested with a comprehensive battery of neuropsychological tests. Handedness was assessed using a single oral question. Learning and/or language disorders and obstetrical complications were recorded using childhood records. Common environmental, clinical and biological parameters were assessed.
Results
The prevalence of NRH and mixed-handedness were, respectively, 11.6 and 2.4%. Learning/language disorders were found in 9.7% out of the total sample and were associated with atypical handedness (only dyslexia for mixed-handedness (
p
< 0.01), and dyslexia and dysphasia for NRH (
p
= 0.01 and
p
= 0.04, respectively). In multivariate analyses, NRH was associated with a younger age of BD onset (aOR 0.98 (95% CI 0.96–0.99) and lifetime substance use disorder (aOR 1.40 (95% CI 1.03–1.82) but not with any of the cognitive subtasks. Mixed-handedness was associated in univariate analyses with lifetime substance use disorder, lifetime cannabis use disorder (all
p
< 0.01) and less mood stabilizer prescription (
p
= 0.028). No association was found between NRH or mixed-handedness and the following parameters: trauma history, obstetrical complications, prior psychotic symptoms, bipolar subtype, attention deficit/hyperactivity disorder, peripheral inflammation or body mass index.
Conclusions
Handedness may be associated with specific features in BD, possibly reflecting a specific subgroup with a neurodevelopmental load.</description><subject>Analysis</subject><subject>Antidepressants</subject><subject>Attention deficit hyperactivity disorder</subject><subject>Batteries</subject><subject>Bipolar disorder</subject><subject>Body mass index</subject><subject>Cannabis</subject><subject>Children</subject><subject>Cognition</subject><subject>Cognitive ability</subject><subject>Cognitive science</subject><subject>Drug use</subject><subject>Dyslexia</subject><subject>Handedness</subject><subject>Human health and pathology</subject><subject>Language</subject><subject>Language disorders</subject><subject>Life Sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neurodevelopmental disorders</subject><subject>Neuroscience</subject><subject>Neurosciences</subject><subject>Original Paper</subject><subject>Psychiatrics and mental health</subject><subject>Psychiatry</subject><subject>Substance use</subject><subject>Trauma</subject><issn>0940-1334</issn><issn>1433-8491</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp9kUGLFDEQhRtR3HH1D3gKePLQa6WT7qS9jeOuIwx40XNIJ5WdLD2dNknP4r83a4uLIFJQBY_vFQ9eVb2mcEUBxLsEwKGroaE1UEZ5zZ5UG8oZqyXv6dNqAz2HmjLGL6oXKd0BAG0beF5dMM4El7zZVOe9nizaCVMifiKDn8OoI7E-hWgxFjERnVIwXme05N7nI0kzGu-8IRMuMVg84xjmE05Zj8ShzkvE9J6UtYw5keBIPiL58LG-2e6uiQnHEPPL6pnTY8JXv-9l9e3m-utuXx--fPq82x5qw1uWawNWSEeldS0ayc3QdkJKtEa4jnGDThsnrKSiGVqkZfV66HsYTO9ko7Fjl9Xb9e9Rj2qO_qTjDxW0V_vtQT1owNqW9Z0408K-Wdk5hu8LpqzuwhKnEk81nZRC0L6BR-pWj6j85EKO2px8MmorKFDBmGgKdfUPqozFkzdhQueL_pehWQ0mhpQiuj9pKaiHttXatiptq19tK1ZMbDWlAk-3GB8T_8f1E-8LqoU</recordid><startdate>20220801</startdate><enddate>20220801</enddate><creator>Mallet, Jasmina</creator><creator>Godin, Ophélia</creator><creator>Mazer, Nicolas</creator><creator>Le Strat, Yann</creator><creator>Bellivier, Frank</creator><creator>Belzeaux, Raoul</creator><creator>Etain, Bruno</creator><creator>Fond, Guillaume</creator><creator>Gard, Sébastien</creator><creator>Henry, Chantal</creator><creator>Leboyer, Marion</creator><creator>Llorca, Pierre-Michel</creator><creator>Loftus, Joséphine</creator><creator>Olié, Emilie</creator><creator>Passerieux, Christine</creator><creator>Polosan, Mircea</creator><creator>Schwan, Raymund</creator><creator>Roux, Paul</creator><creator>Dubertret, Caroline</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><general>Springer Verlag</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0001-5050-1362</orcidid><orcidid>https://orcid.org/0000-0003-4130-1590</orcidid><orcidid>https://orcid.org/0000-0002-1059-5584</orcidid><orcidid>https://orcid.org/0000-0002-3660-6640</orcidid><orcidid>https://orcid.org/0000-0001-7438-8990</orcidid><orcidid>https://orcid.org/0000-0002-3985-4885</orcidid><orcidid>https://orcid.org/0000-0002-5377-1488</orcidid><orcidid>https://orcid.org/0000-0002-6519-8586</orcidid><orcidid>https://orcid.org/0000-0003-3249-2030</orcidid><orcidid>https://orcid.org/0000-0003-0321-4189</orcidid><orcidid>https://orcid.org/0000-0003-1222-6050</orcidid><orcidid>https://orcid.org/0000-0001-5004-5475</orcidid><orcidid>https://orcid.org/0000-0001-5473-3697</orcidid><orcidid>https://orcid.org/0000-0002-4907-8568</orcidid></search><sort><creationdate>20220801</creationdate><title>Handedness in bipolar disorders is associated with specific neurodevelopmental features: results of the BD-FACE cohort</title><author>Mallet, Jasmina ; Godin, Ophélia ; Mazer, Nicolas ; Le Strat, Yann ; Bellivier, Frank ; Belzeaux, Raoul ; Etain, Bruno ; Fond, Guillaume ; Gard, Sébastien ; Henry, Chantal ; Leboyer, Marion ; Llorca, Pierre-Michel ; Loftus, Joséphine ; Olié, Emilie ; Passerieux, Christine ; Polosan, Mircea ; Schwan, Raymund ; Roux, Paul ; Dubertret, Caroline</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c453t-c0d78f18df5ec84cb56788edc7f634cefacf7d8172b5e12b59ab990bc9f82ae63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Analysis</topic><topic>Antidepressants</topic><topic>Attention deficit hyperactivity disorder</topic><topic>Batteries</topic><topic>Bipolar disorder</topic><topic>Body mass index</topic><topic>Cannabis</topic><topic>Children</topic><topic>Cognition</topic><topic>Cognitive ability</topic><topic>Cognitive science</topic><topic>Drug use</topic><topic>Dyslexia</topic><topic>Handedness</topic><topic>Human health and pathology</topic><topic>Language</topic><topic>Language disorders</topic><topic>Life Sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neurodevelopmental disorders</topic><topic>Neuroscience</topic><topic>Neurosciences</topic><topic>Original Paper</topic><topic>Psychiatrics and mental health</topic><topic>Psychiatry</topic><topic>Substance use</topic><topic>Trauma</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mallet, Jasmina</creatorcontrib><creatorcontrib>Godin, Ophélia</creatorcontrib><creatorcontrib>Mazer, Nicolas</creatorcontrib><creatorcontrib>Le Strat, Yann</creatorcontrib><creatorcontrib>Bellivier, Frank</creatorcontrib><creatorcontrib>Belzeaux, Raoul</creatorcontrib><creatorcontrib>Etain, Bruno</creatorcontrib><creatorcontrib>Fond, Guillaume</creatorcontrib><creatorcontrib>Gard, Sébastien</creatorcontrib><creatorcontrib>Henry, Chantal</creatorcontrib><creatorcontrib>Leboyer, Marion</creatorcontrib><creatorcontrib>Llorca, Pierre-Michel</creatorcontrib><creatorcontrib>Loftus, Joséphine</creatorcontrib><creatorcontrib>Olié, Emilie</creatorcontrib><creatorcontrib>Passerieux, Christine</creatorcontrib><creatorcontrib>Polosan, Mircea</creatorcontrib><creatorcontrib>Schwan, Raymund</creatorcontrib><creatorcontrib>Roux, Paul</creatorcontrib><creatorcontrib>Dubertret, Caroline</creatorcontrib><creatorcontrib>the FACE-BD (FondaMental Academic Centers of Expertise for Bipolar Disorder) Group</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>European archives of psychiatry and clinical neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mallet, Jasmina</au><au>Godin, Ophélia</au><au>Mazer, Nicolas</au><au>Le Strat, Yann</au><au>Bellivier, Frank</au><au>Belzeaux, Raoul</au><au>Etain, Bruno</au><au>Fond, Guillaume</au><au>Gard, Sébastien</au><au>Henry, Chantal</au><au>Leboyer, Marion</au><au>Llorca, Pierre-Michel</au><au>Loftus, Joséphine</au><au>Olié, Emilie</au><au>Passerieux, Christine</au><au>Polosan, Mircea</au><au>Schwan, Raymund</au><au>Roux, Paul</au><au>Dubertret, Caroline</au><aucorp>the FACE-BD (FondaMental Academic Centers of Expertise for Bipolar Disorder) Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Handedness in bipolar disorders is associated with specific neurodevelopmental features: results of the BD-FACE cohort</atitle><jtitle>European archives of psychiatry and clinical neuroscience</jtitle><stitle>Eur Arch Psychiatry Clin Neurosci</stitle><date>2022-08-01</date><risdate>2022</risdate><volume>272</volume><issue>5</issue><spage>827</spage><epage>838</epage><pages>827-838</pages><issn>0940-1334</issn><eissn>1433-8491</eissn><abstract>Objectives
High rates of non-right-handedness (NRH) and mixed-handedness exist in neurodevelopmental disorders. Dysfunctional neurodevelopmental pathways may be implicated in the underlying pathophysiology of bipolar disorders (BD), at least in some subgroups. Yet little is known about correlates of NRH and mixed-handedness in BD. The objectives of this national study are to determine (i) the prevalence of NRH and mixed-handedness in a well-stabilized sample of BD individuals; (ii) if NRH/mixed-handedness in BD is associated with a different clinical, biological and neurocognitive profile.
Methods
We included 2174 stabilized individuals. Participants were tested with a comprehensive battery of neuropsychological tests. Handedness was assessed using a single oral question. Learning and/or language disorders and obstetrical complications were recorded using childhood records. Common environmental, clinical and biological parameters were assessed.
Results
The prevalence of NRH and mixed-handedness were, respectively, 11.6 and 2.4%. Learning/language disorders were found in 9.7% out of the total sample and were associated with atypical handedness (only dyslexia for mixed-handedness (
p
< 0.01), and dyslexia and dysphasia for NRH (
p
= 0.01 and
p
= 0.04, respectively). In multivariate analyses, NRH was associated with a younger age of BD onset (aOR 0.98 (95% CI 0.96–0.99) and lifetime substance use disorder (aOR 1.40 (95% CI 1.03–1.82) but not with any of the cognitive subtasks. Mixed-handedness was associated in univariate analyses with lifetime substance use disorder, lifetime cannabis use disorder (all
p
< 0.01) and less mood stabilizer prescription (
p
= 0.028). No association was found between NRH or mixed-handedness and the following parameters: trauma history, obstetrical complications, prior psychotic symptoms, bipolar subtype, attention deficit/hyperactivity disorder, peripheral inflammation or body mass index.
Conclusions
Handedness may be associated with specific features in BD, possibly reflecting a specific subgroup with a neurodevelopmental load.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>34374842</pmid><doi>10.1007/s00406-021-01314-3</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0001-5050-1362</orcidid><orcidid>https://orcid.org/0000-0003-4130-1590</orcidid><orcidid>https://orcid.org/0000-0002-1059-5584</orcidid><orcidid>https://orcid.org/0000-0002-3660-6640</orcidid><orcidid>https://orcid.org/0000-0001-7438-8990</orcidid><orcidid>https://orcid.org/0000-0002-3985-4885</orcidid><orcidid>https://orcid.org/0000-0002-5377-1488</orcidid><orcidid>https://orcid.org/0000-0002-6519-8586</orcidid><orcidid>https://orcid.org/0000-0003-3249-2030</orcidid><orcidid>https://orcid.org/0000-0003-0321-4189</orcidid><orcidid>https://orcid.org/0000-0003-1222-6050</orcidid><orcidid>https://orcid.org/0000-0001-5004-5475</orcidid><orcidid>https://orcid.org/0000-0001-5473-3697</orcidid><orcidid>https://orcid.org/0000-0002-4907-8568</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0940-1334 |
| ispartof | European archives of psychiatry and clinical neuroscience, 2022-08, Vol.272 (5), p.827-838 |
| issn | 0940-1334 1433-8491 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_03553967v1 |
| source | SpringerLink Journals |
| subjects | Analysis Antidepressants Attention deficit hyperactivity disorder Batteries Bipolar disorder Body mass index Cannabis Children Cognition Cognitive ability Cognitive science Drug use Dyslexia Handedness Human health and pathology Language Language disorders Life Sciences Medicine Medicine & Public Health Neurodevelopmental disorders Neuroscience Neurosciences Original Paper Psychiatrics and mental health Psychiatry Substance use Trauma |
| title | Handedness in bipolar disorders is associated with specific neurodevelopmental features: results of the BD-FACE cohort |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T15%3A26%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_hal_p&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Handedness%20in%20bipolar%20disorders%20is%20associated%20with%20specific%20neurodevelopmental%20features:%20results%20of%20the%20BD-FACE%20cohort&rft.jtitle=European%20archives%20of%20psychiatry%20and%20clinical%20neuroscience&rft.au=Mallet,%20Jasmina&rft.aucorp=the%20FACE-BD%20(FondaMental%20Academic%20Centers%20of%20Expertise%20for%20Bipolar%20Disorder)%20Group&rft.date=2022-08-01&rft.volume=272&rft.issue=5&rft.spage=827&rft.epage=838&rft.pages=827-838&rft.issn=0940-1334&rft.eissn=1433-8491&rft_id=info:doi/10.1007/s00406-021-01314-3&rft_dat=%3Cgale_hal_p%3EA710173372%3C/gale_hal_p%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2688771920&rft_id=info:pmid/34374842&rft_galeid=A710173372&rfr_iscdi=true |