Human Dental Pulp Fibroblasts Express the “Cold-sensing” Transient Receptor Potential Channels TRPA1 and TRPM8

Abstract Introduction Transient receptor potential (TRP) channels comprise a group of nonselective calcium-permeable cationic channels, which are polymodal sensors of environmental stimuli such as thermal changes and chemicals. TRPM8 and TRPA1 are cold-sensing TRP channels activated by moderate cool...

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Veröffentlicht in:	Journal of endodontics 2011-04, Vol.37 (4), p.473-478
Hauptverfasser:	El Karim, Ikhlas A., BDS, PhD, Linden, Gerard J., BSc, BDS, PhD, Curtis, Timothy M., BSc, PhD, About, Imad, MS, PhD, McGahon, Mary K., BSc, PhD, Irwin, Christopher R., BSc, BDS, PhD, Killough, Simon A., BSc, BDS, PhD, Lundy, Fionnuala T., BSc, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetanilides - pharmacology Acrolein - analogs & derivatives Acrolein - pharmacology Adult Blotting, Western Calcium Channel Blockers - pharmacology Calcium Channels - analysis Calcium Signaling - drug effects Capsaicin - analogs & derivatives Capsaicin - pharmacology Cells, Cultured Cold Temperature Cytophotometry Dental pulp Dental Pulp - cytology Dentistry Endocrinology & Metabolism fibroblasts Fibroblasts - cytology human Humans Immunohistochemistry Life Sciences Membrane Proteins - analysis Menthol - pharmacology Nerve Tissue Proteins - agonists Nerve Tissue Proteins - analysis Nerve Tissue Proteins - antagonists & inhibitors Nociceptors - cytology Nociceptors - drug effects Physical Stimulation Purines - pharmacology Reverse Transcriptase Polymerase Chain Reaction Thermosensing - physiology transient receptor potential Transient Receptor Potential Channels - agonists Transient Receptor Potential Channels - analysis Transient Receptor Potential Channels - antagonists & inhibitors TRPA1 Cation Channel TRPM Cation Channels - agonists TRPM Cation Channels - analysis TRPM Cation Channels - antagonists & inhibitors Young Adult
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