Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator

Light-operated drugs constitute a major target in drug discovery, since they may provide spatiotemporal resolution for the treatment of complex diseases (i.e. chronic pain). JF-NP-26 is an inactive photocaged derivative of the metabotropic glutamate type 5 (mGlu5) receptor negative allosteric modula...

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Veröffentlicht in:	eLife 2017-04, Vol.6
Hauptverfasser:	Font, Joan, López-Cano, Marc, Notartomaso, Serena, Scarselli, Pamela, Di Pietro, Paola, Bresolí-Obach, Roger, Battaglia, Giuseppe, Malhaire, Fanny, Rovira, Xavier, Catena, Juanlo, Giraldo, Jesús, Pin, Jean-Philippe, Fernández Dueñas, Víctor, Goudet, Cyril, Nonell, S. (Santi), Nicoletti, Ferdinando, Llebaria Soldevila, Amadeu, Ciruela Alférez, Francisco
Format:	Artikel
Sprache:	eng
Schlagworte:	Farmacologia Life Sciences Mice (Laboratory animals) Neurociències Neurons and Cognition Neurosciences Pain treatment Pharmacology Ratolins (Animals de laboratori) Tractament del dolor
Online-Zugang:	Volltext
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