Synthesis and biological activities of inositol 1,4,5-trisphosphate mimics related to xylopyranosides

Synthesis and biological activities of inositol 1,4,5-trisphosphate mimics related to xylopyranosides

2ȃ, 3, 4-trisphosphates of (2-hydroxyethyl) α- and β-D-xylopyranosides and 3ȃ, 3, 4-trisphosphates of (3-hydroxypropyl) α- and β-D-xylopyranosides have been prepared from allyl- D-xylosides and showed agonistic properties toward inositol 1,4,5-trisphosphate receptor.

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Veröffentlicht in:Tetrahedron letters 1995-10, Vol.36 (44), p.8023-8026
Hauptverfasser: Moitessier, N., Chrétien, F., Chaplcur, Y., Humeau, C.
Format: Artikel
Sprache:eng
Schlagworte:
adenophostin
calcium release
Chemical Sciences
Inositol 1,4,5-trisphosphate
mimics, xylose
Organic chemistry
Second messengers
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Zusammenfassung:2ȃ, 3, 4-trisphosphates of (2-hydroxyethyl) α- and β-D-xylopyranosides and 3ȃ, 3, 4-trisphosphates of (3-hydroxypropyl) α- and β-D-xylopyranosides have been prepared from allyl- D-xylosides and showed agonistic properties toward inositol 1,4,5-trisphosphate receptor.
ISSN:0040-4039
1873-3581
DOI:10.1016/0040-4039(95)01677-A