Determinants of Post-Operative Cognitive Decline in Elderly People
Background Surgery and anesthesia can result in temporary or permanent deterioration of the cognitive functions, for which causes remain unclear. Objectives In this pilot study, we analyzed the determinants of cognitive decline following a non-emergency elective prosthesis implantation surgery for h...
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| Veröffentlicht in: | The Journal of Prevention of Alzheimer's Disease 2021-07, Vol.8 (3), p.322-328 |
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| container_title | The Journal of Prevention of Alzheimer's Disease |
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| creator | Cartailler, J. Loyer, C. Vanderlynden, E. Nizard, R. Rabuel, C. Coblentz Baumann, L. Hourregue, C. Dumurgier, J. Paquet, C. |
| description | Background
Surgery and anesthesia can result in temporary or permanent deterioration of the cognitive functions, for which causes remain unclear.
Objectives
In this pilot study, we analyzed the determinants of cognitive decline following a non-emergency elective prosthesis implantation surgery for hip or knee.
Design
Prospective single-center study investigating psychomotor response time and changes in MoCA scores between the day before (D-1) and 2 days after (D+2) following surgery at the Lariboisière Hospital (Paris, France).
Participants
60 patients (71.9±7.1-year-old, 72% women) were included.
Measurements
Collected data consisted in sociodemographic data, treatments, comorbidities and the type of anesthesia (local, general or both). Furthermore, we evaluated pain and well-being before as well as after the surgery using point scales.
Results
Post-operative (D+2) MoCA scores were significantly lower than pre-operative ones (D-1) with a median difference of 2 pts [IQR]=4pts, (p |
| doi_str_mv | 10.14283/jpad.2021.13 |
| format | Article |
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Surgery and anesthesia can result in temporary or permanent deterioration of the cognitive functions, for which causes remain unclear.
Objectives
In this pilot study, we analyzed the determinants of cognitive decline following a non-emergency elective prosthesis implantation surgery for hip or knee.
Design
Prospective single-center study investigating psychomotor response time and changes in MoCA scores between the day before (D-1) and 2 days after (D+2) following surgery at the Lariboisière Hospital (Paris, France).
Participants
60 patients (71.9±7.1-year-old, 72% women) were included.
Measurements
Collected data consisted in sociodemographic data, treatments, comorbidities and the type of anesthesia (local, general or both). Furthermore, we evaluated pain and well-being before as well as after the surgery using point scales.
Results
Post-operative (D+2) MoCA scores were significantly lower than pre-operative ones (D-1) with a median difference of 2 pts [IQR]=4pts, (p<0.001), we found no significant difference between locoregional and general anesthesia. Pre-operative benzodiazepine or anticholinergic treatments were also associated to a drop in MoCA scores (p=0.006). Finally, the use of ketamine during anesthesia (p=0.043) and the well-being (p=0.006) evaluated before intervention, were both linked to a reduced cognitive impact.
Conclusion
In this pilot study, we observed a postoperative short-term cognitive decline following a lower limb surgery. We also identified pre and perioperative independent factors linked to cognitive decline following surgery. In a next stage, a larger cohort should be used to confirm the impact of these factors on cognitive decline.</description><identifier>ISSN: 2274-5807</identifier><identifier>EISSN: 2426-0266</identifier><identifier>DOI: 10.14283/jpad.2021.13</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Brief Reports ; Geriatrics/Gerontology ; Human health and pathology ; Life Sciences ; Medicine ; Medicine & Public Health ; Neurology</subject><ispartof>The Journal of Prevention of Alzheimer's Disease, 2021-07, Vol.8 (3), p.322-328</ispartof><rights>Serdi and Springer Nature Switzerland AG 2021</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c382t-84bc0c02f1c7b3d5bca1cb30cc5278aa53189486d3583003c31d5c33a6e93c283</citedby><cites>FETCH-LOGICAL-c382t-84bc0c02f1c7b3d5bca1cb30cc5278aa53189486d3583003c31d5c33a6e93c283</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.14283/jpad.2021.13$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.14283/jpad.2021.13$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,777,781,882,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://hal.science/hal-03519236$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Cartailler, J.</creatorcontrib><creatorcontrib>Loyer, C.</creatorcontrib><creatorcontrib>Vanderlynden, E.</creatorcontrib><creatorcontrib>Nizard, R.</creatorcontrib><creatorcontrib>Rabuel, C.</creatorcontrib><creatorcontrib>Coblentz Baumann, L.</creatorcontrib><creatorcontrib>Hourregue, C.</creatorcontrib><creatorcontrib>Dumurgier, J.</creatorcontrib><creatorcontrib>Paquet, C.</creatorcontrib><title>Determinants of Post-Operative Cognitive Decline in Elderly People</title><title>The Journal of Prevention of Alzheimer's Disease</title><addtitle>J Prev Alzheimers Dis</addtitle><description>Background
Surgery and anesthesia can result in temporary or permanent deterioration of the cognitive functions, for which causes remain unclear.
Objectives
In this pilot study, we analyzed the determinants of cognitive decline following a non-emergency elective prosthesis implantation surgery for hip or knee.
Design
Prospective single-center study investigating psychomotor response time and changes in MoCA scores between the day before (D-1) and 2 days after (D+2) following surgery at the Lariboisière Hospital (Paris, France).
Participants
60 patients (71.9±7.1-year-old, 72% women) were included.
Measurements
Collected data consisted in sociodemographic data, treatments, comorbidities and the type of anesthesia (local, general or both). Furthermore, we evaluated pain and well-being before as well as after the surgery using point scales.
Results
Post-operative (D+2) MoCA scores were significantly lower than pre-operative ones (D-1) with a median difference of 2 pts [IQR]=4pts, (p<0.001), we found no significant difference between locoregional and general anesthesia. Pre-operative benzodiazepine or anticholinergic treatments were also associated to a drop in MoCA scores (p=0.006). Finally, the use of ketamine during anesthesia (p=0.043) and the well-being (p=0.006) evaluated before intervention, were both linked to a reduced cognitive impact.
Conclusion
In this pilot study, we observed a postoperative short-term cognitive decline following a lower limb surgery. We also identified pre and perioperative independent factors linked to cognitive decline following surgery. In a next stage, a larger cohort should be used to confirm the impact of these factors on cognitive decline.</description><subject>Brief Reports</subject><subject>Geriatrics/Gerontology</subject><subject>Human health and pathology</subject><subject>Life Sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neurology</subject><issn>2274-5807</issn><issn>2426-0266</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp1kDFPwzAQhS0EElXpyJ4RhgTbF6fOWFqgSJXaAWbLcZziyo2DnVbqv8dtEBvTPZ2-e6f3ELonOCM55fC062SdUUxJRuAKjWhOixTToriOmk7zlHE8vUWTEHYYY1KSAko-Qs8L3Wu_N61s-5C4Jtm40KfrTnvZm6NO5m7bmotaaGVNqxPTJi-21t6eko12ndV36KaRNujJ7xyjz9eXj_kyXa3f3uezVaqA0z7leaWwwrQhalpBzSoliaoAK8XolEvJgPAy50UNjAPGoIDUTAHIQpegYsIxehx8v6QVnTd76U_CSSOWs5U47zAwUlIojiSyDwPbefd90KEXexOUtla22h2CoAzK-JYxHNF0QJV3IXjd_HkTLC7VinO14lytIBD5bOBD5Nqt9mLnDr6Nyf85-AG8_nm4</recordid><startdate>20210701</startdate><enddate>20210701</enddate><creator>Cartailler, J.</creator><creator>Loyer, C.</creator><creator>Vanderlynden, E.</creator><creator>Nizard, R.</creator><creator>Rabuel, C.</creator><creator>Coblentz Baumann, L.</creator><creator>Hourregue, C.</creator><creator>Dumurgier, J.</creator><creator>Paquet, C.</creator><general>Springer International Publishing</general><general>SERDI éd</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope></search><sort><creationdate>20210701</creationdate><title>Determinants of Post-Operative Cognitive Decline in Elderly People</title><author>Cartailler, J. ; Loyer, C. ; Vanderlynden, E. ; Nizard, R. ; Rabuel, C. ; Coblentz Baumann, L. ; Hourregue, C. ; Dumurgier, J. ; Paquet, C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c382t-84bc0c02f1c7b3d5bca1cb30cc5278aa53189486d3583003c31d5c33a6e93c283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Brief Reports</topic><topic>Geriatrics/Gerontology</topic><topic>Human health and pathology</topic><topic>Life Sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neurology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cartailler, J.</creatorcontrib><creatorcontrib>Loyer, C.</creatorcontrib><creatorcontrib>Vanderlynden, E.</creatorcontrib><creatorcontrib>Nizard, R.</creatorcontrib><creatorcontrib>Rabuel, C.</creatorcontrib><creatorcontrib>Coblentz Baumann, L.</creatorcontrib><creatorcontrib>Hourregue, C.</creatorcontrib><creatorcontrib>Dumurgier, J.</creatorcontrib><creatorcontrib>Paquet, C.</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><jtitle>The Journal of Prevention of Alzheimer's Disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cartailler, J.</au><au>Loyer, C.</au><au>Vanderlynden, E.</au><au>Nizard, R.</au><au>Rabuel, C.</au><au>Coblentz Baumann, L.</au><au>Hourregue, C.</au><au>Dumurgier, J.</au><au>Paquet, C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Determinants of Post-Operative Cognitive Decline in Elderly People</atitle><jtitle>The Journal of Prevention of Alzheimer's Disease</jtitle><stitle>J Prev Alzheimers Dis</stitle><date>2021-07-01</date><risdate>2021</risdate><volume>8</volume><issue>3</issue><spage>322</spage><epage>328</epage><pages>322-328</pages><issn>2274-5807</issn><eissn>2426-0266</eissn><abstract>Background
Surgery and anesthesia can result in temporary or permanent deterioration of the cognitive functions, for which causes remain unclear.
Objectives
In this pilot study, we analyzed the determinants of cognitive decline following a non-emergency elective prosthesis implantation surgery for hip or knee.
Design
Prospective single-center study investigating psychomotor response time and changes in MoCA scores between the day before (D-1) and 2 days after (D+2) following surgery at the Lariboisière Hospital (Paris, France).
Participants
60 patients (71.9±7.1-year-old, 72% women) were included.
Measurements
Collected data consisted in sociodemographic data, treatments, comorbidities and the type of anesthesia (local, general or both). Furthermore, we evaluated pain and well-being before as well as after the surgery using point scales.
Results
Post-operative (D+2) MoCA scores were significantly lower than pre-operative ones (D-1) with a median difference of 2 pts [IQR]=4pts, (p<0.001), we found no significant difference between locoregional and general anesthesia. Pre-operative benzodiazepine or anticholinergic treatments were also associated to a drop in MoCA scores (p=0.006). Finally, the use of ketamine during anesthesia (p=0.043) and the well-being (p=0.006) evaluated before intervention, were both linked to a reduced cognitive impact.
Conclusion
In this pilot study, we observed a postoperative short-term cognitive decline following a lower limb surgery. We also identified pre and perioperative independent factors linked to cognitive decline following surgery. In a next stage, a larger cohort should be used to confirm the impact of these factors on cognitive decline.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><doi>10.14283/jpad.2021.13</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | Springer Nature - Complete Springer Journals |
| subjects | Brief Reports Geriatrics/Gerontology Human health and pathology Life Sciences Medicine Medicine & Public Health Neurology |
| title | Determinants of Post-Operative Cognitive Decline in Elderly People |
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