Glutathione peroxidase mimics based on conformationally-restricted, peri -like, 4,5-disubstituted fluorene dichalcogenides
Glutathione peroxidase (GPx) regulates cellular peroxide levels through glutathione oxidation. GPx-mimics based on 4,5-disubstituted fluorene diselenides, their oxides, and ditellurides show catalytic activities consistent with conformational restriction about the dichalcogen bond.
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| Veröffentlicht in: | Organic & biomolecular chemistry 2021-12, Vol.19 (48), p.10565-10569 |
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| container_end_page | 10569 |
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| container_issue | 48 |
| container_start_page | 10565 |
| container_title | Organic & biomolecular chemistry |
| container_volume | 19 |
| creator | Jagdev, Kesar Tanini, Damiano Lownes, Jack W Figliola, Carlotta Male, Louise Capperucci, Antonella Grainger, Richard S |
| description | Glutathione peroxidase (GPx) regulates cellular peroxide levels through glutathione oxidation. GPx-mimics based on 4,5-disubstituted fluorene diselenides, their oxides, and ditellurides show catalytic activities consistent with conformational restriction about the dichalcogen bond. |
| doi_str_mv | 10.1039/d1ob02153b |
| format | Article |
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| ispartof | Organic & biomolecular chemistry, 2021-12, Vol.19 (48), p.10565-10569 |
| issn | 1477-0520 1477-0539 |
| language | eng |
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| source | Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Biochemistry Biochemistry, Molecular Biology Catalysis Chalcogenides Chemical Sciences Fluorene Glutathione Glutathione peroxidase Life Sciences Organic chemistry Oxidation Peroxidase Selenides Vitamin E |
| title | Glutathione peroxidase mimics based on conformationally-restricted, peri -like, 4,5-disubstituted fluorene dichalcogenides |
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