Impact of the nature and concentration of plasticizers on the ability of PVC to sorb drug

[Display omitted] The sorption of a drug by an infusion set may dramatically reduce the drug delivery efficiency. In this paper, we investigated how the drug sorption, in static conditions, is affected by the plasticizer’s nature and ratio in the case of plasticized PVC, one of the most common mater...

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Veröffentlicht in:	International journal of pharmaceutics 2015-12, Vol.496 (2), p.664-675
Hauptverfasser:	Al Salloum, H., Saunier, J., Aymes-Chodur, C., Barakat, H., Yagoubi, N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemical Sciences DEHP Diazepam Diazepam - metabolism Drug sorption Partition coefficients Plasticizer Plasticizers - chemistry Plasticizers - pharmacokinetics Polyvinyl Chloride - chemistry Polyvinyl Chloride - pharmacokinetics PVC
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