Telomeric Chromatin and TERRA
Chromatin function in telomeres is poorly understood, but it is generally viewed as repressive. Yet, telomeric DNA sequences are transcribed into long non-coding RNAs named TElomere Repeat-containing RNA (TERRA). As TERRA molecules mostly localize at telomeres, major research efforts have been made...
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| Veröffentlicht in: | Journal of molecular biology 2020-07, Vol.432 (15), p.4244-4256 |
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| container_title | Journal of molecular biology |
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| creator | Barral, Amandine Déjardin, Jérome |
| description | Chromatin function in telomeres is poorly understood, but it is generally viewed as repressive. Yet, telomeric DNA sequences are transcribed into long non-coding RNAs named TElomere Repeat-containing RNA (TERRA). As TERRA molecules mostly localize at telomeres, major research efforts have been made to understand their functions, and how TERRA transcription is regulated and affects telomere structure. This review describes the current state of knowledge about the nature of chromatin at telomeres, its functions, and the relation between chromatin structure and TERRA.
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•Telomeric chromatin states are dynamic depending on the cell type and the mode of telomere maintenance.•TERRA production depends on the telomeric chromatin state.•Details about TERRA mediated chromatin regulation remain to be identified |
| doi_str_mv | 10.1016/j.jmb.2020.03.003 |
| format | Article |
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•Telomeric chromatin states are dynamic depending on the cell type and the mode of telomere maintenance.•TERRA production depends on the telomeric chromatin state.•Details about TERRA mediated chromatin regulation remain to be identified</description><identifier>ISSN: 0022-2836</identifier><identifier>EISSN: 1089-8638</identifier><identifier>DOI: 10.1016/j.jmb.2020.03.003</identifier><identifier>PMID: 32151584</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>chromatin ; Chromatin - genetics ; Chromatin - metabolism ; Gene Expression Regulation ; heterochromatin ; Life Sciences ; lncRNA ; RNA, Long Noncoding - genetics ; telomere ; Telomere - genetics ; TERRA</subject><ispartof>Journal of molecular biology, 2020-07, Vol.432 (15), p.4244-4256</ispartof><rights>2020 Elsevier Ltd</rights><rights>Copyright © 2020 Elsevier Ltd. All rights reserved.</rights><rights>Attribution - NonCommercial</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c430t-84bd7b08d37436d7f2e1f5e29435bbceab8bbeb8163a95b94952869dc7d1ca263</citedby><cites>FETCH-LOGICAL-c430t-84bd7b08d37436d7f2e1f5e29435bbceab8bbeb8163a95b94952869dc7d1ca263</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0022283620302242$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32151584$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-03491403$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Barral, Amandine</creatorcontrib><creatorcontrib>Déjardin, Jérome</creatorcontrib><title>Telomeric Chromatin and TERRA</title><title>Journal of molecular biology</title><addtitle>J Mol Biol</addtitle><description>Chromatin function in telomeres is poorly understood, but it is generally viewed as repressive. Yet, telomeric DNA sequences are transcribed into long non-coding RNAs named TElomere Repeat-containing RNA (TERRA). As TERRA molecules mostly localize at telomeres, major research efforts have been made to understand their functions, and how TERRA transcription is regulated and affects telomere structure. This review describes the current state of knowledge about the nature of chromatin at telomeres, its functions, and the relation between chromatin structure and TERRA.
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•Telomeric chromatin states are dynamic depending on the cell type and the mode of telomere maintenance.•TERRA production depends on the telomeric chromatin state.•Details about TERRA mediated chromatin regulation remain to be identified</description><subject>chromatin</subject><subject>Chromatin - genetics</subject><subject>Chromatin - metabolism</subject><subject>Gene Expression Regulation</subject><subject>heterochromatin</subject><subject>Life Sciences</subject><subject>lncRNA</subject><subject>RNA, Long Noncoding - genetics</subject><subject>telomere</subject><subject>Telomere - genetics</subject><subject>TERRA</subject><issn>0022-2836</issn><issn>1089-8638</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLw0AQgBdRtD5-gAelRz0kzj6y2eCplPqAgiD1vOxjgluSRnfTgv_elKhHTwPDN9_AR8glhZwClXfrfN3anAGDHHgOwA_IhIKqMiW5OiQTAMYyprg8IacprQGg4EIdkxPOaEELJSbkaoVN12IMbjp_j11r-rCZmo2frhavr7NzclSbJuHFzzwjbw-L1fwpW748Ps9ny8wJDn2mhPWlBeV5Kbj0Zc2Q1gWySvDCWofGKmvRKiq5qQpbiapgSlbelZ46wyQ_I7ej9900-iOG1sQv3Zmgn2ZLvd8BFxUVwHd0YG9G9iN2n1tMvW5Dctg0ZoPdNmnGy0JJIUENKB1RF7uUItZ_bgp6X1Cv9VBQ7wsOL_RQcLi5_tFvbYv-7-I32QDcjwAOQXYBo04u4MahDxFdr30X_tF_A4OkfWk</recordid><startdate>20200710</startdate><enddate>20200710</enddate><creator>Barral, Amandine</creator><creator>Déjardin, Jérome</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope></search><sort><creationdate>20200710</creationdate><title>Telomeric Chromatin and TERRA</title><author>Barral, Amandine ; Déjardin, Jérome</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c430t-84bd7b08d37436d7f2e1f5e29435bbceab8bbeb8163a95b94952869dc7d1ca263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>chromatin</topic><topic>Chromatin - genetics</topic><topic>Chromatin - metabolism</topic><topic>Gene Expression Regulation</topic><topic>heterochromatin</topic><topic>Life Sciences</topic><topic>lncRNA</topic><topic>RNA, Long Noncoding - genetics</topic><topic>telomere</topic><topic>Telomere - genetics</topic><topic>TERRA</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Barral, Amandine</creatorcontrib><creatorcontrib>Déjardin, Jérome</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><jtitle>Journal of molecular biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Barral, Amandine</au><au>Déjardin, Jérome</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Telomeric Chromatin and TERRA</atitle><jtitle>Journal of molecular biology</jtitle><addtitle>J Mol Biol</addtitle><date>2020-07-10</date><risdate>2020</risdate><volume>432</volume><issue>15</issue><spage>4244</spage><epage>4256</epage><pages>4244-4256</pages><issn>0022-2836</issn><eissn>1089-8638</eissn><abstract>Chromatin function in telomeres is poorly understood, but it is generally viewed as repressive. Yet, telomeric DNA sequences are transcribed into long non-coding RNAs named TElomere Repeat-containing RNA (TERRA). As TERRA molecules mostly localize at telomeres, major research efforts have been made to understand their functions, and how TERRA transcription is regulated and affects telomere structure. This review describes the current state of knowledge about the nature of chromatin at telomeres, its functions, and the relation between chromatin structure and TERRA.
[Display omitted]
•Telomeric chromatin states are dynamic depending on the cell type and the mode of telomere maintenance.•TERRA production depends on the telomeric chromatin state.•Details about TERRA mediated chromatin regulation remain to be identified</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>32151584</pmid><doi>10.1016/j.jmb.2020.03.003</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | chromatin Chromatin - genetics Chromatin - metabolism Gene Expression Regulation heterochromatin Life Sciences lncRNA RNA, Long Noncoding - genetics telomere Telomere - genetics TERRA |
| title | Telomeric Chromatin and TERRA |
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