Should we reconsider cefazolin for treating staphylococcal meningitis? A retrospective analysis of cefazolin and cloxacillin cerebrospinal fluid levels in patients treated for staphylococcal meningitis

To assess the meningeal penetration of cefazolin and cloxacillin in individuals treated for methicillin-susceptible staphylococcal meningitis. We retrospectively identified individuals treated for Staphylococcus meningitis with measurements of cefazolin or cloxacillin concentrations in cerebrospinal...

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Veröffentlicht in:	Clinical microbiology and infection 2020-10, Vol.26 (10), p.1415.e1-1415.e4
Hauptverfasser:	Le Turnier, P., Gregoire, M., Deslandes, G., Lakhal, K., Deschanvres, C., Lecomte, R., Talarmin, J.-P., Dubée, V., Bellouard, R., Boutoille, D., Leroy, A.-G., Gaborit, B.J., Raffi, Francois, Boutoille, David, Biron, Charlotte, Lefebvre, Maeva, Gaborit, Benjamin Jean, Le Turnier, Paul, Deschanvres, Colin, Lecomte, Raphael, Chauveau, Marie, Asseray, Nathalie, Gregoire, Matthieu, Bellouard, Ronan, Deslandes, Guillaume, Dailly, Eric, Leroy, Anne-Gaëlle, Corvec, Stéphane, Bémer, Pascale, Caillon, Jocelyne, Guillouzouic, Aurélie, Lakhal, Karim, Cinotti, Raphaël, Canet, Emmanuel, Bretonniere, Cédric, Guimard, Thomas, Brochard, Julia, Talarmin, Jean Philippe, Katchatourian, Lydie
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Anti-Bacterial Agents - cerebrospinal fluid Anti-Bacterial Agents - therapeutic use Cefazolin Cefazolin - cerebrospinal fluid Cefazolin - therapeutic use Cerebrospinal fluid antibiotic dosage Chromatography, Liquid Cloxacillin Cloxacillin - cerebrospinal fluid Cloxacillin - therapeutic use Female Humans Life Sciences Male Mass Spectrometry Meningitis Meningitis, Bacterial - drug therapy Middle Aged Retrospective Studies Staphylococcal Infections - drug therapy Staphylococcus aureus Staphylococcus aureus - drug effects Staphylococcus epidermidis Therapeutic drug monitoring
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