Neurocognitive impairment is associated with erectile dysfunction in cirrhotic patients
Erectile dysfunction (ED) is common in patients with chronic diseases. It is evaluated using the International Index of Erectile Function (IIEF5) questionnaire. The relationship between ED and cirrhosis is complex. The aims of our study were (1) to assess the prevalence of ED in cirrhosis and (2) to...
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| Veröffentlicht in: | Digestive and liver disease 2019-06, Vol.51 (6), p.850-855 |
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| creator | Philonenko, Sara Rivière, Pauline Mallet, Maxime Poullenot, Florian Tripon, Simona Munteanu, Mona Boukherrouf, Ryad Sultanik, Philippe Roupret, Morgan Thabut, Dominique Rudler, Marika |
| description | Erectile dysfunction (ED) is common in patients with chronic diseases. It is evaluated using the International Index of Erectile Function (IIEF5) questionnaire. The relationship between ED and cirrhosis is complex. The aims of our study were (1) to assess the prevalence of ED in cirrhosis and (2) to evaluate factors associated with ED, with a special focus on minimal hepatic encephalopathy (MHE).
We performed a prospective, observational study. Patients with cirrhosis were invited to complete the IIEF5 questionnaire. The exclusion criteria were clinical hepatic encephalopathy (HE) and dementia. MHE was evaluated by the psychometric hepatic encephalopathy test score (PHES) and the critical flicker frequency (CFF).
Between April 2016 and April 2017, 87 patients were included (age: 55 [51–57] years, Child–Pugh score: 8 [7–9], MELD score: 13 [11–16]. Minimal HE was diagnosed in 33% of the patients according to the PHES and in 44% of the patients according to the CFF. ED was diagnosed in 74/87 patients (85%) when compared to 12.5% in healthy controls (p |
| doi_str_mv | 10.1016/j.dld.2019.03.030 |
| format | Article |
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We performed a prospective, observational study. Patients with cirrhosis were invited to complete the IIEF5 questionnaire. The exclusion criteria were clinical hepatic encephalopathy (HE) and dementia. MHE was evaluated by the psychometric hepatic encephalopathy test score (PHES) and the critical flicker frequency (CFF).
Between April 2016 and April 2017, 87 patients were included (age: 55 [51–57] years, Child–Pugh score: 8 [7–9], MELD score: 13 [11–16]. Minimal HE was diagnosed in 33% of the patients according to the PHES and in 44% of the patients according to the CFF. ED was diagnosed in 74/87 patients (85%) when compared to 12.5% in healthy controls (p < 0.001). In a multivariate analysis, the independent factors associated with ED were age, Child–Pugh and MELD scores. Significant correlations were identified between the IIEF5 and each component of the PHES.
ED should be systematically screened in cirrhotics, especially in patients with MHE.</description><identifier>ISSN: 1590-8658</identifier><identifier>EISSN: 1878-3562</identifier><identifier>DOI: 10.1016/j.dld.2019.03.030</identifier><identifier>PMID: 31031175</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Cirrhosis ; Erectile dysfunction ; Erectile Dysfunction - diagnosis ; Erectile Dysfunction - etiology ; Flicker Fusion ; Hepatic encephalopathy ; Hepatic Encephalopathy - complications ; Hepatic Encephalopathy - pathology ; Humans ; Life Sciences ; Liver Cirrhosis - complications ; Liver Cirrhosis - pathology ; Logistic Models ; Male ; Middle Aged ; Multivariate Analysis ; Prevalence ; Prospective Studies ; Severity of Illness Index</subject><ispartof>Digestive and liver disease, 2019-06, Vol.51 (6), p.850-855</ispartof><rights>2019 Editrice Gastroenterologica Italiana S.r.l.</rights><rights>Copyright © 2019 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.</rights><rights>Attribution - NonCommercial</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c430t-17becfc2ec52b131abd9ecdc39958deba766dfa75ea2ed4acc6e81ef0707a1823</citedby><cites>FETCH-LOGICAL-c430t-17becfc2ec52b131abd9ecdc39958deba766dfa75ea2ed4acc6e81ef0707a1823</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.dld.2019.03.030$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,778,782,883,3539,27911,27912,45982</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31031175$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-03484485$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Philonenko, Sara</creatorcontrib><creatorcontrib>Rivière, Pauline</creatorcontrib><creatorcontrib>Mallet, Maxime</creatorcontrib><creatorcontrib>Poullenot, Florian</creatorcontrib><creatorcontrib>Tripon, Simona</creatorcontrib><creatorcontrib>Munteanu, Mona</creatorcontrib><creatorcontrib>Boukherrouf, Ryad</creatorcontrib><creatorcontrib>Sultanik, Philippe</creatorcontrib><creatorcontrib>Roupret, Morgan</creatorcontrib><creatorcontrib>Thabut, Dominique</creatorcontrib><creatorcontrib>Rudler, Marika</creatorcontrib><title>Neurocognitive impairment is associated with erectile dysfunction in cirrhotic patients</title><title>Digestive and liver disease</title><addtitle>Dig Liver Dis</addtitle><description>Erectile dysfunction (ED) is common in patients with chronic diseases. It is evaluated using the International Index of Erectile Function (IIEF5) questionnaire. The relationship between ED and cirrhosis is complex. The aims of our study were (1) to assess the prevalence of ED in cirrhosis and (2) to evaluate factors associated with ED, with a special focus on minimal hepatic encephalopathy (MHE).
We performed a prospective, observational study. Patients with cirrhosis were invited to complete the IIEF5 questionnaire. The exclusion criteria were clinical hepatic encephalopathy (HE) and dementia. MHE was evaluated by the psychometric hepatic encephalopathy test score (PHES) and the critical flicker frequency (CFF).
Between April 2016 and April 2017, 87 patients were included (age: 55 [51–57] years, Child–Pugh score: 8 [7–9], MELD score: 13 [11–16]. Minimal HE was diagnosed in 33% of the patients according to the PHES and in 44% of the patients according to the CFF. ED was diagnosed in 74/87 patients (85%) when compared to 12.5% in healthy controls (p < 0.001). In a multivariate analysis, the independent factors associated with ED were age, Child–Pugh and MELD scores. Significant correlations were identified between the IIEF5 and each component of the PHES.
ED should be systematically screened in cirrhotics, especially in patients with MHE.</description><subject>Cirrhosis</subject><subject>Erectile dysfunction</subject><subject>Erectile Dysfunction - diagnosis</subject><subject>Erectile Dysfunction - etiology</subject><subject>Flicker Fusion</subject><subject>Hepatic encephalopathy</subject><subject>Hepatic Encephalopathy - complications</subject><subject>Hepatic Encephalopathy - pathology</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Liver Cirrhosis - complications</subject><subject>Liver Cirrhosis - pathology</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Prevalence</subject><subject>Prospective Studies</subject><subject>Severity of Illness Index</subject><issn>1590-8658</issn><issn>1878-3562</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1r3DAQhk1paD7aH9BL0bE9eKORLEumpxDaJrC0l5YehSyNu1psayvJW_LvK7NJjoEBDeJ9n4Gnqt4D3QCF9nq_caPbMArdhvIy9FV1AUqqmouWvS676GitWqHOq8uU9pQyaAV9U51zoBxAiovq93dcYrDhz-yzPyLx08H4OOGciU_EpBSsNxkd-efzjmBEm_2IxD2kYZnLHmbiZ2J9jLuQvSUHk30pp7fV2WDGhO8e36vq19cvP2_v6u2Pb_e3N9vaNpzmGmSPdrAMrWA9cDC969A6y7tOKIe9kW3rBiMFGoauMda2qAAHKqk0oBi_qj6duDsz6kP0k4kPOhiv7262ev2jvFFNo8QRSvbjKXuI4e-CKevJJ4vjaGYMS9Ks6JESWLti4RS1MaQUcXhmA9Wre73Xxb1e3ZcTZWjpfHjEL_2E7rnxJLsEPp8CWIQcPUadbJFl0fnVq3bBv4D_D78xlmw</recordid><startdate>20190601</startdate><enddate>20190601</enddate><creator>Philonenko, Sara</creator><creator>Rivière, Pauline</creator><creator>Mallet, Maxime</creator><creator>Poullenot, Florian</creator><creator>Tripon, Simona</creator><creator>Munteanu, Mona</creator><creator>Boukherrouf, Ryad</creator><creator>Sultanik, Philippe</creator><creator>Roupret, Morgan</creator><creator>Thabut, Dominique</creator><creator>Rudler, Marika</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope></search><sort><creationdate>20190601</creationdate><title>Neurocognitive impairment is associated with erectile dysfunction in cirrhotic patients</title><author>Philonenko, Sara ; Rivière, Pauline ; Mallet, Maxime ; Poullenot, Florian ; Tripon, Simona ; Munteanu, Mona ; Boukherrouf, Ryad ; Sultanik, Philippe ; Roupret, Morgan ; Thabut, Dominique ; Rudler, Marika</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c430t-17becfc2ec52b131abd9ecdc39958deba766dfa75ea2ed4acc6e81ef0707a1823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Cirrhosis</topic><topic>Erectile dysfunction</topic><topic>Erectile Dysfunction - diagnosis</topic><topic>Erectile Dysfunction - etiology</topic><topic>Flicker Fusion</topic><topic>Hepatic encephalopathy</topic><topic>Hepatic Encephalopathy - complications</topic><topic>Hepatic Encephalopathy - pathology</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Liver Cirrhosis - complications</topic><topic>Liver Cirrhosis - pathology</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Prevalence</topic><topic>Prospective Studies</topic><topic>Severity of Illness Index</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Philonenko, Sara</creatorcontrib><creatorcontrib>Rivière, Pauline</creatorcontrib><creatorcontrib>Mallet, Maxime</creatorcontrib><creatorcontrib>Poullenot, Florian</creatorcontrib><creatorcontrib>Tripon, Simona</creatorcontrib><creatorcontrib>Munteanu, Mona</creatorcontrib><creatorcontrib>Boukherrouf, Ryad</creatorcontrib><creatorcontrib>Sultanik, Philippe</creatorcontrib><creatorcontrib>Roupret, Morgan</creatorcontrib><creatorcontrib>Thabut, Dominique</creatorcontrib><creatorcontrib>Rudler, Marika</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><jtitle>Digestive and liver disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Philonenko, Sara</au><au>Rivière, Pauline</au><au>Mallet, Maxime</au><au>Poullenot, Florian</au><au>Tripon, Simona</au><au>Munteanu, Mona</au><au>Boukherrouf, Ryad</au><au>Sultanik, Philippe</au><au>Roupret, Morgan</au><au>Thabut, Dominique</au><au>Rudler, Marika</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neurocognitive impairment is associated with erectile dysfunction in cirrhotic patients</atitle><jtitle>Digestive and liver disease</jtitle><addtitle>Dig Liver Dis</addtitle><date>2019-06-01</date><risdate>2019</risdate><volume>51</volume><issue>6</issue><spage>850</spage><epage>855</epage><pages>850-855</pages><issn>1590-8658</issn><eissn>1878-3562</eissn><abstract>Erectile dysfunction (ED) is common in patients with chronic diseases. It is evaluated using the International Index of Erectile Function (IIEF5) questionnaire. The relationship between ED and cirrhosis is complex. The aims of our study were (1) to assess the prevalence of ED in cirrhosis and (2) to evaluate factors associated with ED, with a special focus on minimal hepatic encephalopathy (MHE).
We performed a prospective, observational study. Patients with cirrhosis were invited to complete the IIEF5 questionnaire. The exclusion criteria were clinical hepatic encephalopathy (HE) and dementia. MHE was evaluated by the psychometric hepatic encephalopathy test score (PHES) and the critical flicker frequency (CFF).
Between April 2016 and April 2017, 87 patients were included (age: 55 [51–57] years, Child–Pugh score: 8 [7–9], MELD score: 13 [11–16]. Minimal HE was diagnosed in 33% of the patients according to the PHES and in 44% of the patients according to the CFF. ED was diagnosed in 74/87 patients (85%) when compared to 12.5% in healthy controls (p < 0.001). In a multivariate analysis, the independent factors associated with ED were age, Child–Pugh and MELD scores. Significant correlations were identified between the IIEF5 and each component of the PHES.
ED should be systematically screened in cirrhotics, especially in patients with MHE.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>31031175</pmid><doi>10.1016/j.dld.2019.03.030</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Digestive and liver disease, 2019-06, Vol.51 (6), p.850-855 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Cirrhosis Erectile dysfunction Erectile Dysfunction - diagnosis Erectile Dysfunction - etiology Flicker Fusion Hepatic encephalopathy Hepatic Encephalopathy - complications Hepatic Encephalopathy - pathology Humans Life Sciences Liver Cirrhosis - complications Liver Cirrhosis - pathology Logistic Models Male Middle Aged Multivariate Analysis Prevalence Prospective Studies Severity of Illness Index |
| title | Neurocognitive impairment is associated with erectile dysfunction in cirrhotic patients |
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