Granulopoiesis and Neutrophil Homeostasis: A Metabolic, Daily Balancing Act

Granulopoiesis is part of the hematopoietic hierarchic architecture, where hematopoietic stem cells give rise to highly proliferative multipotent and lineage-committed granulocytic progenitor cells that differentiate into unipotent neutrophil progenitors. Given their short lifespan, neutrophils are...

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Veröffentlicht in:	Trends in immunology 2019-07, Vol.40 (7), p.598-612
Hauptverfasser:	Yvan-Charvet, Laurent, Ng, Lai Guan
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Bone marrow Cancer Circadian rhythms Gene expression Granulocytes Granulopoiesis Hematopoiesis Hematopoietic stem cells Heterogeneity Homeostasis Immunological tolerance Inflammatory diseases Leukocytes (neutrophilic) Life Sciences Life span Macrophages Mammals Metabolism Neutropenia Neutrophils Population Progenitor cells Proteins Regulatory mechanisms (biology) Stem cells Studies Transcription factors Variation
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