An oxidative N-demethylase reveals PAS transition from ubiquitous sensor to enzyme

Characterization of the first Per-ARNT-Sim enzyme, a haem-dependent oxidative N -demethylase. Enzyme activity of a Per-ARNT-Sim domain Per-ARNT-Sim (PAS) domains are widely distributed interaction modules found in signal transduction proteins across all domains of life. They are involved in sensing...

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Veröffentlicht in:	Nature (London) 2016-11, Vol.539 (7630), p.593-597
Hauptverfasser:	Ortmayer, Mary, Lafite, Pierre, Menon, Binuraj R. K., Tralau, Tewes, Fisher, Karl, Denkhaus, Lukas, Scrutton, Nigel S., Rigby, Stephen E. J., Munro, Andrew W., Hay, Sam, Leys, David
Format:	Artikel
Sprache:	eng
Schlagworte:	631/181/735 631/45/173 631/535/1266 704/47/4113 Binding Sites Biochemistry, Molecular Biology Cellular signal transduction Coenzymes - metabolism Crystallography, X-Ray Cytochrome Dimethylamines - metabolism Enzymes Flavin Mononucleotide - metabolism Heme - metabolism Humanities and Social Sciences Iron-Sulfur Proteins - chemistry Iron-Sulfur Proteins - metabolism letter Life Sciences Ligands Models, Molecular multidisciplinary NADP - metabolism Observations Oxidation Oxidation-Reduction Oxidoreductases Oxidoreductases, N-Demethylating - chemistry Oxidoreductases, N-Demethylating - metabolism Oxygen - metabolism Physiological aspects Protein Domains Protein Subunits - chemistry Protein Subunits - metabolism Pseudomonas mendocina - enzymology Science Spectrum analysis Tetrahydrofolates - metabolism
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