Minimum information about animal experiments: supplier is also important
It has now been established that functional recovery after spinal cord injury (SCI) depends on several parameters, including animal strain. Here we demonstrate that rats from the same strain (Wistar) but from two independent commercial suppliers present different motor, sensory, and autonomic outcom...
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| Veröffentlicht in: | Journal of neuroscience research 2009-02, Vol.87 (2), p.403-407 |
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| container_title | Journal of neuroscience research |
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| creator | Lonjon, Nicolas Prieto, Monica Haton, Henri Brøchner, Christian B. Bauchet, Luc Costalat, Vincent Privat, Alain Gaviria, Manuel Perrin, Florence E. |
| description | It has now been established that functional recovery after spinal cord injury (SCI) depends on several parameters, including animal strain. Here we demonstrate that rats from the same strain (Wistar) but from two independent commercial suppliers present different motor, sensory, and autonomic outcomes after a standard model of SCI, the so‐called compression model. Recovery is correlated with the extension of the lesion, and we show that the vertebral canal diameter varies between the two suppliers. To substantiate this point, we carried out another set of experiments, with the so‐called contusion model, which requires bone ablation and thus whose extension is not related to vertebral canal diameter. We show that there is no difference between the two suppliers. The purpose of our communication is to alert researchers on how crucial it is to control experimental parameters as closely as possible and to establish a standard for animal experiment in order to avoid unexpected biases. © 2008 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/jnr.21871 |
| format | Article |
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Here we demonstrate that rats from the same strain (Wistar) but from two independent commercial suppliers present different motor, sensory, and autonomic outcomes after a standard model of SCI, the so‐called compression model. Recovery is correlated with the extension of the lesion, and we show that the vertebral canal diameter varies between the two suppliers. To substantiate this point, we carried out another set of experiments, with the so‐called contusion model, which requires bone ablation and thus whose extension is not related to vertebral canal diameter. We show that there is no difference between the two suppliers. The purpose of our communication is to alert researchers on how crucial it is to control experimental parameters as closely as possible and to establish a standard for animal experiment in order to avoid unexpected biases. © 2008 Wiley‐Liss, Inc.</description><identifier>ISSN: 0360-4012</identifier><identifier>EISSN: 1097-4547</identifier><identifier>DOI: 10.1002/jnr.21871</identifier><identifier>PMID: 18798282</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Animal Experimentation - standards ; Animals ; Biomedical Research - standards ; Disease Models, Animal ; functional recovery ; lesion extension ; Life Sciences ; Neurobiology ; Neurons and Cognition ; Rats ; Rats, Wistar ; Recovery of Function ; SCI ; Spinal Cord Injuries - pathology ; supplier ; vertebral canal</subject><ispartof>Journal of neuroscience research, 2009-02, Vol.87 (2), p.403-407</ispartof><rights>Copyright © 2008 Wiley‐Liss, Inc.</rights><rights>2008 Wiley-Liss, Inc.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4261-aaef073465c882bec4b1aa23835290098f237739d012f61a1116e99216515c2a3</citedby><cites>FETCH-LOGICAL-c4261-aaef073465c882bec4b1aa23835290098f237739d012f61a1116e99216515c2a3</cites><orcidid>0000-0002-7630-0515 ; 0000-0001-8428-9101 ; 0000-0003-1077-2496 ; 0000-0003-2983-9582</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjnr.21871$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjnr.21871$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18798282$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-03476124$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Lonjon, Nicolas</creatorcontrib><creatorcontrib>Prieto, Monica</creatorcontrib><creatorcontrib>Haton, Henri</creatorcontrib><creatorcontrib>Brøchner, Christian B.</creatorcontrib><creatorcontrib>Bauchet, Luc</creatorcontrib><creatorcontrib>Costalat, Vincent</creatorcontrib><creatorcontrib>Privat, Alain</creatorcontrib><creatorcontrib>Gaviria, Manuel</creatorcontrib><creatorcontrib>Perrin, Florence E.</creatorcontrib><title>Minimum information about animal experiments: supplier is also important</title><title>Journal of neuroscience research</title><addtitle>J. Neurosci. Res</addtitle><description>It has now been established that functional recovery after spinal cord injury (SCI) depends on several parameters, including animal strain. Here we demonstrate that rats from the same strain (Wistar) but from two independent commercial suppliers present different motor, sensory, and autonomic outcomes after a standard model of SCI, the so‐called compression model. Recovery is correlated with the extension of the lesion, and we show that the vertebral canal diameter varies between the two suppliers. To substantiate this point, we carried out another set of experiments, with the so‐called contusion model, which requires bone ablation and thus whose extension is not related to vertebral canal diameter. We show that there is no difference between the two suppliers. 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Prieto, Monica ; Haton, Henri ; Brøchner, Christian B. ; Bauchet, Luc ; Costalat, Vincent ; Privat, Alain ; Gaviria, Manuel ; Perrin, Florence E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4261-aaef073465c882bec4b1aa23835290098f237739d012f61a1116e99216515c2a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Animal Experimentation - standards</topic><topic>Animals</topic><topic>Biomedical Research - standards</topic><topic>Disease Models, Animal</topic><topic>functional recovery</topic><topic>lesion extension</topic><topic>Life Sciences</topic><topic>Neurobiology</topic><topic>Neurons and Cognition</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Recovery of Function</topic><topic>SCI</topic><topic>Spinal Cord Injuries - pathology</topic><topic>supplier</topic><topic>vertebral canal</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lonjon, Nicolas</creatorcontrib><creatorcontrib>Prieto, Monica</creatorcontrib><creatorcontrib>Haton, Henri</creatorcontrib><creatorcontrib>Brøchner, Christian B.</creatorcontrib><creatorcontrib>Bauchet, Luc</creatorcontrib><creatorcontrib>Costalat, Vincent</creatorcontrib><creatorcontrib>Privat, Alain</creatorcontrib><creatorcontrib>Gaviria, Manuel</creatorcontrib><creatorcontrib>Perrin, Florence E.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Journal of neuroscience research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lonjon, Nicolas</au><au>Prieto, Monica</au><au>Haton, Henri</au><au>Brøchner, Christian B.</au><au>Bauchet, Luc</au><au>Costalat, Vincent</au><au>Privat, Alain</au><au>Gaviria, Manuel</au><au>Perrin, Florence E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Minimum information about animal experiments: supplier is also important</atitle><jtitle>Journal of neuroscience research</jtitle><addtitle>J. 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| language | eng |
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| subjects | Animal Experimentation - standards Animals Biomedical Research - standards Disease Models, Animal functional recovery lesion extension Life Sciences Neurobiology Neurons and Cognition Rats Rats, Wistar Recovery of Function SCI Spinal Cord Injuries - pathology supplier vertebral canal |
| title | Minimum information about animal experiments: supplier is also important |
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