HLA-H02:07 Is a Membrane-Bound Ligand of Denisovan Origin That Protects against Lysis by Activated Immune Effectors

The biological relevance of genes initially categorized as "pseudogenes" is slowly emerging, notably in innate immunity. In the HLA region on chromosome 6, is one such pseudogene; yet, it is transcribed, and its variation is associated with immune properties. Furthermore, two alleles, * an...

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Veröffentlicht in:	The Journal of immunology (1950) 2022-01, Vol.208 (1), p.49-53
Hauptverfasser:	Hubert, Lucas, Paganini, Julien, Picard, Christophe, Chiaroni, Jacques, Abi-Rached, Laurent, Pontarotti, Pierre, Di Cristofaro, Julie
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Asians Cell Membrane - metabolism Cytotoxicity, Immunologic Evolution, Molecular Gene Frequency Genotype Haplotypes Hemochromatosis Protein - genetics Hemochromatosis Protein - metabolism HLA-A11 Antigen - genetics Homeostasis Humans Immune Tolerance K562 Cells Killer Cells, Natural - immunology Life Sciences Lymphocyte Activation Pseudogenes - genetics Whites
Online-Zugang:	Volltext
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