Pregnancy-Related Complications in Patients With Fibromuscular Dysplasia: A Report From the European/International Fibromuscular Dysplasia Registry
Current literature suggests a higher risk of pregnancy-related complications in patients with renal fibromuscular dysplasia (FMD). The aim of our study was to assess the nature and prevalence of pregnancy-related complications in patients subsequently diagnosed with FMD. A call for participation was...
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| Veröffentlicht in: | Hypertension (Dallas, Tex. 1979) Tex. 1979), 2020-08, Vol.76 (2), p.545-553 |
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| creator | Pappaccogli, Marco Prejbisz, Aleksander Ciurică, Simina Bruno, Rosa Maria Aniszczuk-Hybiak, Anna Bracalente, Irene De Backer, Tine Debiève, Frédéric Delmotte, Philippe Di Monaco, Silvia Jarraya, Faiçal Gordin, Daniel Kosiński, Przemysław Kroon, Abraham A. Maas, Angela H.E.M. Marcon, Denise Minuz, Pietro Montagud-Marrahi, Enrique Pasquet, Agnès Poch, Esteban Rabbia, Franco Stergiou, George S. Tikkanen, Ilkka Toubiana, Laurent Vinck, Wouter Warchoł-Celińska, Ewa Van der Niepen, Patricia de Leeuw, Peter Januszewicz, Andrzej Persu, Alexandre |
| description | Current literature suggests a higher risk of pregnancy-related complications in patients with renal fibromuscular dysplasia (FMD). The aim of our study was to assess the nature and prevalence of pregnancy-related complications in patients subsequently diagnosed with FMD. A call for participation was sent to centers contributing to the European/International FMD Registry. Patients with at least 1 pregnancy were included. Data on pregnancy were collected through medical files and FMD characteristics through the European/International FMD Registry. Data from 534 pregnancies were obtained in 237 patients. Despite the fact that, in 96% of cases, FMD was not diagnosed before pregnancy, 40% of women (n=93) experienced pregnancy-related complications, mostly gestational hypertension (25%) and preterm birth (20%), while preeclampsia was reported in only 7.5%. Only 1 patient experienced arterial dissection and another patient an aneurysm rupture. When compared with patients without pregnancy-related complications, patients with complicated pregnancies were younger at FMD diagnosis (43 versus 51 years old; P |
| doi_str_mv | 10.1161/HYPERTENSIONAHA.120.15349 |
| format | Article |
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The aim of our study was to assess the nature and prevalence of pregnancy-related complications in patients subsequently diagnosed with FMD. A call for participation was sent to centers contributing to the European/International FMD Registry. Patients with at least 1 pregnancy were included. Data on pregnancy were collected through medical files and FMD characteristics through the European/International FMD Registry. Data from 534 pregnancies were obtained in 237 patients. Despite the fact that, in 96% of cases, FMD was not diagnosed before pregnancy, 40% of women (n=93) experienced pregnancy-related complications, mostly gestational hypertension (25%) and preterm birth (20%), while preeclampsia was reported in only 7.5%. Only 1 patient experienced arterial dissection and another patient an aneurysm rupture. When compared with patients without pregnancy-related complications, patients with complicated pregnancies were younger at FMD diagnosis (43 versus 51 years old; P<0.001) and had a lower prevalence of cerebrovascular FMD (30% versus 52%; P=0.003) but underwent more often renal revascularization (63% versus 40%, P<0.001). In conclusion, the prevalence of pregnancy-related complications such as gestational hypertension and preterm birth was high in patients with FMD, probably related to the severity of renal FMD. However, the prevalence of preeclampsia and arterial complications was low/moderate. These findings emphasize the need to screen hypertensive women for FMD to ensure revascularization before pregnancy if indicated and appropriate follow-up during pregnancy, without discouraging patients with FMD from considering pregnancy.</description><identifier>ISSN: 0194-911X</identifier><identifier>EISSN: 1524-4563</identifier><identifier>DOI: 10.1161/HYPERTENSIONAHA.120.15349</identifier><identifier>PMID: 32639884</identifier><language>eng</language><publisher>United States: American Heart Association, Inc</publisher><subject>Adult ; Bioinformatics ; Comorbidity ; Computer Science ; Female ; Fibromuscular Dysplasia - epidemiology ; Fibromuscular Dysplasia - physiopathology ; Humans ; Middle Aged ; Pregnancy ; Pregnancy Complications - epidemiology ; Pregnancy Complications - physiopathology ; Premature Birth - epidemiology ; Premature Birth - physiopathology ; Prevalence ; Registries ; Renal Artery - physiopathology ; Young Adult</subject><ispartof>Hypertension (Dallas, Tex. 1979), 2020-08, Vol.76 (2), p.545-553</ispartof><rights>American Heart Association, Inc</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3409-fa978181fb4994e99c880d051e04718a20e3c22c28c93b7a7fc1df121fcc244e3</cites><orcidid>0000-0003-4107-8122 ; 0000-0002-1849-9829 ; 0000-0002-6401-1580 ; 0000-0002-4007-9695</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,3674,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32639884$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-03467688$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Pappaccogli, Marco</creatorcontrib><creatorcontrib>Prejbisz, Aleksander</creatorcontrib><creatorcontrib>Ciurică, Simina</creatorcontrib><creatorcontrib>Bruno, Rosa Maria</creatorcontrib><creatorcontrib>Aniszczuk-Hybiak, Anna</creatorcontrib><creatorcontrib>Bracalente, Irene</creatorcontrib><creatorcontrib>De Backer, Tine</creatorcontrib><creatorcontrib>Debiève, Frédéric</creatorcontrib><creatorcontrib>Delmotte, Philippe</creatorcontrib><creatorcontrib>Di Monaco, Silvia</creatorcontrib><creatorcontrib>Jarraya, Faiçal</creatorcontrib><creatorcontrib>Gordin, Daniel</creatorcontrib><creatorcontrib>Kosiński, Przemysław</creatorcontrib><creatorcontrib>Kroon, Abraham A.</creatorcontrib><creatorcontrib>Maas, Angela H.E.M.</creatorcontrib><creatorcontrib>Marcon, Denise</creatorcontrib><creatorcontrib>Minuz, Pietro</creatorcontrib><creatorcontrib>Montagud-Marrahi, Enrique</creatorcontrib><creatorcontrib>Pasquet, Agnès</creatorcontrib><creatorcontrib>Poch, Esteban</creatorcontrib><creatorcontrib>Rabbia, Franco</creatorcontrib><creatorcontrib>Stergiou, George S.</creatorcontrib><creatorcontrib>Tikkanen, Ilkka</creatorcontrib><creatorcontrib>Toubiana, Laurent</creatorcontrib><creatorcontrib>Vinck, Wouter</creatorcontrib><creatorcontrib>Warchoł-Celińska, Ewa</creatorcontrib><creatorcontrib>Van der Niepen, Patricia</creatorcontrib><creatorcontrib>de Leeuw, Peter</creatorcontrib><creatorcontrib>Januszewicz, Andrzej</creatorcontrib><creatorcontrib>Persu, Alexandre</creatorcontrib><creatorcontrib>European/International Fibromuscular Dysplasia Registry and Initiative (FEIRI) and the Working Group “Hypertension and the Kidney” of the ESH</creatorcontrib><creatorcontrib>on behalf of the European/International Fibromuscular Dysplasia Registry and Initiative (FEIRI) and the Working Group “Hypertension and the Kidney” of the ESH</creatorcontrib><title>Pregnancy-Related Complications in Patients With Fibromuscular Dysplasia: A Report From the European/International Fibromuscular Dysplasia Registry</title><title>Hypertension (Dallas, Tex. 1979)</title><addtitle>Hypertension</addtitle><description>Current literature suggests a higher risk of pregnancy-related complications in patients with renal fibromuscular dysplasia (FMD). The aim of our study was to assess the nature and prevalence of pregnancy-related complications in patients subsequently diagnosed with FMD. A call for participation was sent to centers contributing to the European/International FMD Registry. Patients with at least 1 pregnancy were included. Data on pregnancy were collected through medical files and FMD characteristics through the European/International FMD Registry. Data from 534 pregnancies were obtained in 237 patients. Despite the fact that, in 96% of cases, FMD was not diagnosed before pregnancy, 40% of women (n=93) experienced pregnancy-related complications, mostly gestational hypertension (25%) and preterm birth (20%), while preeclampsia was reported in only 7.5%. Only 1 patient experienced arterial dissection and another patient an aneurysm rupture. When compared with patients without pregnancy-related complications, patients with complicated pregnancies were younger at FMD diagnosis (43 versus 51 years old; P<0.001) and had a lower prevalence of cerebrovascular FMD (30% versus 52%; P=0.003) but underwent more often renal revascularization (63% versus 40%, P<0.001). In conclusion, the prevalence of pregnancy-related complications such as gestational hypertension and preterm birth was high in patients with FMD, probably related to the severity of renal FMD. However, the prevalence of preeclampsia and arterial complications was low/moderate. These findings emphasize the need to screen hypertensive women for FMD to ensure revascularization before pregnancy if indicated and appropriate follow-up during pregnancy, without discouraging patients with FMD from considering pregnancy.</description><subject>Adult</subject><subject>Bioinformatics</subject><subject>Comorbidity</subject><subject>Computer Science</subject><subject>Female</subject><subject>Fibromuscular Dysplasia - epidemiology</subject><subject>Fibromuscular Dysplasia - physiopathology</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>Pregnancy</subject><subject>Pregnancy Complications - epidemiology</subject><subject>Pregnancy Complications - physiopathology</subject><subject>Premature Birth - epidemiology</subject><subject>Premature Birth - physiopathology</subject><subject>Prevalence</subject><subject>Registries</subject><subject>Renal Artery - physiopathology</subject><subject>Young Adult</subject><issn>0194-911X</issn><issn>1524-4563</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc1uEzEUhS0EoqHwCsjsYDGt_zJjsxuFhESK2igUASvLcTwdg2c82B6qPEdfuG5TukDCkuWf-51zLR8A3mF0hnGJz5c_NvPt1fziy-ryol7WZ5jkwpQy8QxM8JSwgk1L-hxMEBasEBh_PwGvYvyJEGaMVS_BCSUlFZyzCbjdBHPdq14fiq1xKpk9nPlucFarZH0foe3hJm9NnyL8ZlMLF3YXfDdGPToV4KdDHJyKVn2ENdyawYcEF7kOU2vgfAx-MKo_X_XJhP7BUbn_OWT5tY0pHF6DF41y0bx5XE_B18X8arYs1pefV7N6XWjKkCgaJSqOOW52TAhmhNCcoz2aYoNYhbkiyFBNiCZcC7qrVNVovG8wwY3WhDFDT8GHo2-rnByC7VQ4SK-sXNZreX-HKCurkvM_OLPvj-wQ_O_RxCQ7G7VxTvXGj1ESRgjKfasyo-KI6uBjDKZ58sZI3ucn_8lP5vzkQ35Z-_axzbjrzP5J-TewDLAjcONd_tP4y403JsjWKJdaifJgpOQFQfk1PJ-KPKmgd3tIqk4</recordid><startdate>20200801</startdate><enddate>20200801</enddate><creator>Pappaccogli, Marco</creator><creator>Prejbisz, Aleksander</creator><creator>Ciurică, Simina</creator><creator>Bruno, Rosa Maria</creator><creator>Aniszczuk-Hybiak, Anna</creator><creator>Bracalente, Irene</creator><creator>De Backer, Tine</creator><creator>Debiève, Frédéric</creator><creator>Delmotte, Philippe</creator><creator>Di Monaco, Silvia</creator><creator>Jarraya, Faiçal</creator><creator>Gordin, Daniel</creator><creator>Kosiński, Przemysław</creator><creator>Kroon, Abraham A.</creator><creator>Maas, Angela H.E.M.</creator><creator>Marcon, Denise</creator><creator>Minuz, Pietro</creator><creator>Montagud-Marrahi, Enrique</creator><creator>Pasquet, Agnès</creator><creator>Poch, Esteban</creator><creator>Rabbia, Franco</creator><creator>Stergiou, George S.</creator><creator>Tikkanen, Ilkka</creator><creator>Toubiana, Laurent</creator><creator>Vinck, Wouter</creator><creator>Warchoł-Celińska, Ewa</creator><creator>Van der Niepen, Patricia</creator><creator>de Leeuw, Peter</creator><creator>Januszewicz, Andrzej</creator><creator>Persu, Alexandre</creator><general>American Heart Association, Inc</general><general>American Heart Association</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0003-4107-8122</orcidid><orcidid>https://orcid.org/0000-0002-1849-9829</orcidid><orcidid>https://orcid.org/0000-0002-6401-1580</orcidid><orcidid>https://orcid.org/0000-0002-4007-9695</orcidid></search><sort><creationdate>20200801</creationdate><title>Pregnancy-Related Complications in Patients With Fibromuscular Dysplasia: A Report From the European/International Fibromuscular Dysplasia Registry</title><author>Pappaccogli, Marco ; Prejbisz, Aleksander ; Ciurică, Simina ; Bruno, Rosa Maria ; Aniszczuk-Hybiak, Anna ; Bracalente, Irene ; De Backer, Tine ; Debiève, Frédéric ; Delmotte, Philippe ; Di Monaco, Silvia ; Jarraya, Faiçal ; Gordin, Daniel ; Kosiński, Przemysław ; Kroon, Abraham A. ; Maas, Angela H.E.M. ; Marcon, Denise ; Minuz, Pietro ; Montagud-Marrahi, Enrique ; Pasquet, Agnès ; Poch, Esteban ; Rabbia, Franco ; Stergiou, George S. ; Tikkanen, Ilkka ; Toubiana, Laurent ; Vinck, Wouter ; Warchoł-Celińska, Ewa ; Van der Niepen, Patricia ; de Leeuw, Peter ; Januszewicz, Andrzej ; Persu, Alexandre</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3409-fa978181fb4994e99c880d051e04718a20e3c22c28c93b7a7fc1df121fcc244e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Bioinformatics</topic><topic>Comorbidity</topic><topic>Computer Science</topic><topic>Female</topic><topic>Fibromuscular Dysplasia - 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The aim of our study was to assess the nature and prevalence of pregnancy-related complications in patients subsequently diagnosed with FMD. A call for participation was sent to centers contributing to the European/International FMD Registry. Patients with at least 1 pregnancy were included. Data on pregnancy were collected through medical files and FMD characteristics through the European/International FMD Registry. Data from 534 pregnancies were obtained in 237 patients. Despite the fact that, in 96% of cases, FMD was not diagnosed before pregnancy, 40% of women (n=93) experienced pregnancy-related complications, mostly gestational hypertension (25%) and preterm birth (20%), while preeclampsia was reported in only 7.5%. Only 1 patient experienced arterial dissection and another patient an aneurysm rupture. When compared with patients without pregnancy-related complications, patients with complicated pregnancies were younger at FMD diagnosis (43 versus 51 years old; P<0.001) and had a lower prevalence of cerebrovascular FMD (30% versus 52%; P=0.003) but underwent more often renal revascularization (63% versus 40%, P<0.001). In conclusion, the prevalence of pregnancy-related complications such as gestational hypertension and preterm birth was high in patients with FMD, probably related to the severity of renal FMD. However, the prevalence of preeclampsia and arterial complications was low/moderate. 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| fulltext | fulltext |
| identifier | ISSN: 0194-911X |
| ispartof | Hypertension (Dallas, Tex. 1979), 2020-08, Vol.76 (2), p.545-553 |
| issn | 0194-911X 1524-4563 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_03467688v1 |
| source | MEDLINE; American Heart Association Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult Bioinformatics Comorbidity Computer Science Female Fibromuscular Dysplasia - epidemiology Fibromuscular Dysplasia - physiopathology Humans Middle Aged Pregnancy Pregnancy Complications - epidemiology Pregnancy Complications - physiopathology Premature Birth - epidemiology Premature Birth - physiopathology Prevalence Registries Renal Artery - physiopathology Young Adult |
| title | Pregnancy-Related Complications in Patients With Fibromuscular Dysplasia: A Report From the European/International Fibromuscular Dysplasia Registry |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-31T12%3A06%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_hal_p&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Pregnancy-Related%20Complications%20in%20Patients%20With%20Fibromuscular%20Dysplasia:%20A%20Report%20From%20the%20European/International%20Fibromuscular%20Dysplasia%20Registry&rft.jtitle=Hypertension%20(Dallas,%20Tex.%201979)&rft.au=Pappaccogli,%20Marco&rft.aucorp=European/International%20Fibromuscular%20Dysplasia%20Registry%20and%20Initiative%20(FEIRI)%20and%20the%20Working%20Group%20%E2%80%9CHypertension%20and%20the%20Kidney%E2%80%9D%20of%20the%20ESH&rft.date=2020-08-01&rft.volume=76&rft.issue=2&rft.spage=545&rft.epage=553&rft.pages=545-553&rft.issn=0194-911X&rft.eissn=1524-4563&rft_id=info:doi/10.1161/HYPERTENSIONAHA.120.15349&rft_dat=%3Cproquest_hal_p%3E2422004776%3C/proquest_hal_p%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2422004776&rft_id=info:pmid/32639884&rfr_iscdi=true |