The primary cilium and lipophagy translate mechanical forces to direct metabolic adaptation of kidney epithelial cells

Organs and cells must adapt to shear stress induced by biological fluids, but how fluid flow contributes to the execution of specific cell programs is poorly understood. Here we show that shear stress favours mitochondrial biogenesis and metabolic reprogramming to ensure energy production and cellul...

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Veröffentlicht in:	Nature cell biology 2020-09, Vol.22 (9), p.1091-1102
Hauptverfasser:	Miceli, Caterina, Roccio, Federica, Penalva-Mousset, Lucille, Burtin, Martine, Leroy, Christine, Nemazanyy, Ivan, Kuperwasser, Nicolas, Pontoglio, Marco, Friedlander, Gérard, Morel, Etienne, Terzi, Fabiola, Codogno, Patrice, Dupont, Nicolas
Format:	Artikel
Sprache:	eng
Schlagworte:	13 14 38 631/443/272 631/80/39/2346 64 96 Adaptation Adenosine Triphosphate - metabolism Animals Autophagy Autophagy - physiology Bioenergetics Biomedical and Life Sciences Biosynthesis Cancer Research Cell Biology Cell Line Cellular Biology Cellular manufacture Cilia Cilia - metabolism Cilia - physiology Computational fluid dynamics Cytoskeleton Developmental Biology Energy metabolism Epithelial cells Epithelial Cells - metabolism Epithelial Cells - physiology Epithelium Fatty acids Fluid dynamics Fluid flow Gluconeogenesis Gluconeogenesis - physiology Glucose - metabolism Kidney - metabolism Kidney - physiology Kidneys Life Sciences Lipid metabolism Lipid Metabolism - physiology Lipids Mechanical stimuli Medical examination Metabolism Mice Mice, Inbred C57BL Mitochondria Mitochondria - metabolism Observations Organs Oxidation Phagocytosis Properties Reabsorption Shear stress Stem Cells Stress (Physiology) Stress, Mechanical Substrates
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