A targeted ultra performance liquid chromatography – Tandem mass spectrometric assay for tyrosine and metabolites in urine and plasma: Application to the effects of antibiotics on mice

•A rapid microbore RP-UHPLC-MS assay for tyrosine and 11 metabolites is described.•A “fit-for-purpose” approach was applied to method validation.•The assay was applied to mouse urine and plasma after feeding a high tyrosine diet.•Antibiotics revealed the contribution of the gut microbiota to tyrosin...

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Veröffentlicht in:	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2021-02, Vol.1164, p.122511-122511, Article 122511
Hauptverfasser:	Letertre, Marine P.M., Myridakis, Antonis, Whiley, Luke, Camuzeaux, Stéphane, Lewis, Matthew R., Chappell, Katie E., Thaikkatil, Annie, Dumas, Marc-Emmanuel, Nicholson, Jeremy K., Swann, Jonathan R., Wilson, Ian D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical chemistry Animals Anti-Bacterial Agents Anti-Bacterial Agents - pharmacology Biofluids Chemical Sciences Chromatography, High Pressure Liquid Chromatography, High Pressure Liquid - methods Cresols Cresols - blood Cresols - metabolism Cresols - urine Dansyl chloride Dansyl Compounds Female Gastrointestinal Microbiome Gastrointestinal Microbiome - drug effects Gastrointestinal Microbiome - physiology Human health and pathology Life Sciences Limit of Detection Linear Models Metabolites Mice Mice, Inbred BALB C P-cresol conjugates Quantification Reproducibility of Results Tandem Mass Spectrometry Tandem Mass Spectrometry - methods Tyrosine Tyrosine - blood Tyrosine - metabolism Tyrosine - urine
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