Effects of Angiotensin-1 Converting Enzyme Inhibition on Oxidative Stress and Bradykinin Receptor Expression During Doxorubicin-induced Cardiomyopathy in Rats

To evaluate the mechanisms and the impact of the angiotensin-converting enzyme inhibitor perindopril (P) in a model of doxorubicin (D)-induced cardiotoxicity, male Wistar rats received D (1 mg/kg/d, IP for 10 days), P (2 mg/kg/d by gavage from day 1 to day 18), D (for 10 days) + P (for 18 days) or s...

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Veröffentlicht in:	Journal of cardiovascular pharmacology 2008-09, Vol.52 (3), p.278-285
Hauptverfasser:	Richard, Carole, Lauzier, Benjamin, Delemasure, Stéphanie, Talbot, Sébastien, Ghibu, Stéliana, Collin, Bertrand, Sénécal, Jacques, Menetrier, Franck, Vergely, Catherine, Couture, Réjean, Rochette, Luc
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin-Converting Enzyme Inhibitors - pharmacology Animals Antibiotics, Antineoplastic - toxicity Ascorbic Acid - blood Binding Sites Blood Pressure - drug effects Cardiology and cardiovascular system Cardiomyopathies - chemically induced Cardiomyopathies - drug therapy Chemokine CCL2 - metabolism Doxorubicin - toxicity Gene Expression Regulation - drug effects Human health and pathology Life Sciences Male Natriuretic Peptide, Brain - drug effects Natriuretic Peptide, Brain - metabolism Oxidative Stress - drug effects Perindopril - pharmacology Rats Rats, Wistar Receptor, Bradykinin B1 - drug effects Receptor, Bradykinin B1 - metabolism Receptor, Bradykinin B2 - drug effects Receptor, Bradykinin B2 - metabolism Troponin I - drug effects Troponin I - metabolism
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