Cateslytin abrogates lipopolysaccharide-induced cardiomyocyte injury by reducing inflammation and oxidative stress through toll like receptor 4 interaction

[Display omitted] •Ctl mitigated the LPS-induced cell injury in H9c2 cardiomyocytes.•Ctl modulated TLR4 through a direct binding to the partner protein MD-2.•Ctl suppressed the LPS-dependent inflammation and oxidative stress in H9c2 cells. Global public health is threatened by new pathogens, antimic...

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Veröffentlicht in:	International immunopharmacology 2021-05, Vol.94, p.107487-107487, Article 107487
Hauptverfasser:	Rocca, Carmine, De Bartolo, Anna, Grande, Fedora, Rizzuti, Bruno, Pasqua, Teresa, Giordano, Francesca, Granieri, Maria Concetta, Occhiuzzi, Maria Antonietta, Garofalo, Antonio, Amodio, Nicola, Cerra, Maria Carmela, Schneider, Francis, Panno, Maria Luisa, Metz-Boutigue, Marie Hélène, Angelone, Tommaso
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiinfectives and antibacterials Antimicrobial agents Antimicrobial peptides Antioxidants Carbonyl compounds Carbonyl groups Carbonyls Cardiomyocytes Cateslytin Contractility Cyclooxygenase-2 Cytotoxicity Enantiomers Gene expression Health risks Heart diseases Immunology Inflammation Injury prevention Life Sciences Lipopolysaccharides Lymphocytes T MAP kinase Microorganisms Molecular docking Myocarditis Myocardium NF-κB protein Oxidants Oxidative stress Oxidizing agents Peptides Proteins Public health Sepsis Superoxide dismutase TLR4 protein Toll-like receptor 4 Toll-like receptors Tumor necrosis factor
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