Assessment of the burden of malaria and bacteraemia by retrospective molecular diagnosis in febrile illnesses and first-line anti-infectives in Côte d'Ivoire
The aetiologies of fever are poorly understood in sub-Saharan Africa. We aimed to assess the burden of malaria and bacteria in Côte d’Ivoire. Blood samples from 438 febrile and 346 afebrile people were screened using molecular tools. Plasmodium falciparum was the most common microorganism associated...
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| Veröffentlicht in: | Travel medicine and infectious disease 2021-09, Vol.43, p.102105-102105, Article 102105 |
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| creator | Ehounoud, Bilé Cyrille Hervé Boumbanda Koyo, Celia Scherelle Doua Bongue, Landry Cortaredona, Sébastien N’Douba Kakou, Adèle Konan, Djanwai Berenger Kouassi Patrick, Yao Amanzougaghene, Nadia N’Guessan, Jean-David Davoust, Bernard Raoult, Didier Mediannikov, Oleg Fenollar, Florence |
| description | The aetiologies of fever are poorly understood in sub-Saharan Africa. We aimed to assess the burden of malaria and bacteria in Côte d’Ivoire.
Blood samples from 438 febrile and 346 afebrile people were screened using molecular tools.
Plasmodium falciparum was the most common microorganism associated with fever (46.8% in febrile, 23.4% in afebrile people; p |
| doi_str_mv | 10.1016/j.tmaid.2021.102105 |
| format | Article |
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Blood samples from 438 febrile and 346 afebrile people were screened using molecular tools.
Plasmodium falciparum was the most common microorganism associated with fever (46.8% in febrile, 23.4% in afebrile people; p < 0.001). Bacteraemia was detected in 21.7% of febrile people and 12.7% of afebrile people (p = 0.001). Streptococcus pneumoniae was the main cause of bacteraemia (7.1% of febrile and 0.6% of afebrile individuals; p < 0.001). Non-typhoidal Salmonella spp. was detected in 4.5% of febrile people and 1.2% of afebrile individuals (p < 0.001). Salmonella enterica Typhi and S. enterica Paratyphi were only detected in febrile subjects (1.4% and 2.1%), as well as Tropheryma whipplei (0.9%), Streptococcus pyogenes (0.7%), and Plasmodium ovale (4.6%). The prevalence in febrile and afebrile people was similar for Staphylococcus aureus (3.6–4.9%), Rickettsia felis (5.5–6.4%), Mansonella perstans (3.0–3.2%), and Plasmodium malariae (1.6–2.3%). Comorbidities were higher in febrile than in afebrile subjects (10.3% versus 5.5%; p = 0.01); 82% involving P. falciparum. All patients co-infected with P. falciparum and S. pneumoniae were febrile whereas 30% of those infected by P. falciparum alone were not (p = 0.02). Among febrile participants, 30.4% with malaria and 54.7% with bacteraemia had received neither antimalarial nor antibiotic therapy.
Identification of etiologies of acute febrile diseases in sub-Saharan Africa proposes keys to successful treatment and prevention of infectious diseases. Vaccination campaigns may decrease the morbidity of mono- and co-infections by preventable microorganisms.</description><identifier>ISSN: 1477-8939</identifier><identifier>EISSN: 1873-0442</identifier><identifier>DOI: 10.1016/j.tmaid.2021.102105</identifier><language>eng</language><publisher>Philadelphia: Elsevier Ltd</publisher><subject>Age ; Antibiotics ; Asymptomatic ; Bacteraemia ; Bacteria ; Bacteriology ; Cardiology and cardiovascular system ; Côte d’Ivoire ; Emerging diseases ; Epidemiology ; Etiology ; Fever ; Human diseases ; Human health and pathology ; Illnesses ; Infectious diseases ; Life Sciences ; Malaria ; Medical diagnosis ; Microbiology and Parasitology ; Microorganisms ; Parasitology ; Principal components analysis ; Rural areas ; Salmonella ; Salmonella enterica ; Staphylococcus infections ; Streptococcus infections ; Streptococcus pneumoniae ; Travel medicine ; Tropical diseases ; Urban areas ; Vaccination ; Vector-borne diseases ; Virology</subject><ispartof>Travel medicine and infectious disease, 2021-09, Vol.43, p.102105-102105, Article 102105</ispartof><rights>2021 The Authors</rights><rights>2021. The Authors</rights><rights>Attribution - NonCommercial</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c398t-68c04b0ea7b1a95578e404d64b4edabc58802da46eb1a325b5762bf931e3d2603</citedby><cites>FETCH-LOGICAL-c398t-68c04b0ea7b1a95578e404d64b4edabc58802da46eb1a325b5762bf931e3d2603</cites><orcidid>0000-0002-6758-5803 ; 0000-0002-2895-5824 ; 0000-0002-7517-0173 ; 0000-0001-6039-2008 ; 0000-0003-3523-7158 ; 0000-0002-0633-5974 ; 0000-0002-7836-6809</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1477893921001460$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://amu.hal.science/hal-03429328$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Ehounoud, Bilé Cyrille Hervé</creatorcontrib><creatorcontrib>Boumbanda Koyo, Celia Scherelle</creatorcontrib><creatorcontrib>Doua Bongue, Landry</creatorcontrib><creatorcontrib>Cortaredona, Sébastien</creatorcontrib><creatorcontrib>N’Douba Kakou, Adèle</creatorcontrib><creatorcontrib>Konan, Djanwai Berenger</creatorcontrib><creatorcontrib>Kouassi Patrick, Yao</creatorcontrib><creatorcontrib>Amanzougaghene, Nadia</creatorcontrib><creatorcontrib>N’Guessan, Jean-David</creatorcontrib><creatorcontrib>Davoust, Bernard</creatorcontrib><creatorcontrib>Raoult, Didier</creatorcontrib><creatorcontrib>Mediannikov, Oleg</creatorcontrib><creatorcontrib>Fenollar, Florence</creatorcontrib><title>Assessment of the burden of malaria and bacteraemia by retrospective molecular diagnosis in febrile illnesses and first-line anti-infectives in Côte d'Ivoire</title><title>Travel medicine and infectious disease</title><description>The aetiologies of fever are poorly understood in sub-Saharan Africa. We aimed to assess the burden of malaria and bacteria in Côte d’Ivoire.
Blood samples from 438 febrile and 346 afebrile people were screened using molecular tools.
Plasmodium falciparum was the most common microorganism associated with fever (46.8% in febrile, 23.4% in afebrile people; p < 0.001). Bacteraemia was detected in 21.7% of febrile people and 12.7% of afebrile people (p = 0.001). Streptococcus pneumoniae was the main cause of bacteraemia (7.1% of febrile and 0.6% of afebrile individuals; p < 0.001). Non-typhoidal Salmonella spp. was detected in 4.5% of febrile people and 1.2% of afebrile individuals (p < 0.001). Salmonella enterica Typhi and S. enterica Paratyphi were only detected in febrile subjects (1.4% and 2.1%), as well as Tropheryma whipplei (0.9%), Streptococcus pyogenes (0.7%), and Plasmodium ovale (4.6%). The prevalence in febrile and afebrile people was similar for Staphylococcus aureus (3.6–4.9%), Rickettsia felis (5.5–6.4%), Mansonella perstans (3.0–3.2%), and Plasmodium malariae (1.6–2.3%). Comorbidities were higher in febrile than in afebrile subjects (10.3% versus 5.5%; p = 0.01); 82% involving P. falciparum. All patients co-infected with P. falciparum and S. pneumoniae were febrile whereas 30% of those infected by P. falciparum alone were not (p = 0.02). Among febrile participants, 30.4% with malaria and 54.7% with bacteraemia had received neither antimalarial nor antibiotic therapy.
Identification of etiologies of acute febrile diseases in sub-Saharan Africa proposes keys to successful treatment and prevention of infectious diseases. Vaccination campaigns may decrease the morbidity of mono- and co-infections by preventable microorganisms.</description><subject>Age</subject><subject>Antibiotics</subject><subject>Asymptomatic</subject><subject>Bacteraemia</subject><subject>Bacteria</subject><subject>Bacteriology</subject><subject>Cardiology and cardiovascular system</subject><subject>Côte d’Ivoire</subject><subject>Emerging diseases</subject><subject>Epidemiology</subject><subject>Etiology</subject><subject>Fever</subject><subject>Human diseases</subject><subject>Human health and pathology</subject><subject>Illnesses</subject><subject>Infectious diseases</subject><subject>Life Sciences</subject><subject>Malaria</subject><subject>Medical diagnosis</subject><subject>Microbiology and Parasitology</subject><subject>Microorganisms</subject><subject>Parasitology</subject><subject>Principal components analysis</subject><subject>Rural areas</subject><subject>Salmonella</subject><subject>Salmonella 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of the burden of malaria and bacteraemia by retrospective molecular diagnosis in febrile illnesses and first-line anti-infectives in Côte d'Ivoire</title><author>Ehounoud, Bilé Cyrille Hervé ; Boumbanda Koyo, Celia Scherelle ; Doua Bongue, Landry ; Cortaredona, Sébastien ; N’Douba Kakou, Adèle ; Konan, Djanwai Berenger ; Kouassi Patrick, Yao ; Amanzougaghene, Nadia ; N’Guessan, Jean-David ; Davoust, Bernard ; Raoult, Didier ; Mediannikov, Oleg ; Fenollar, Florence</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c398t-68c04b0ea7b1a95578e404d64b4edabc58802da46eb1a325b5762bf931e3d2603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Age</topic><topic>Antibiotics</topic><topic>Asymptomatic</topic><topic>Bacteraemia</topic><topic>Bacteria</topic><topic>Bacteriology</topic><topic>Cardiology and cardiovascular system</topic><topic>Côte d’Ivoire</topic><topic>Emerging 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Florence</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessment of the burden of malaria and bacteraemia by retrospective molecular diagnosis in febrile illnesses and first-line anti-infectives in Côte d'Ivoire</atitle><jtitle>Travel medicine and infectious disease</jtitle><date>2021-09</date><risdate>2021</risdate><volume>43</volume><spage>102105</spage><epage>102105</epage><pages>102105-102105</pages><artnum>102105</artnum><issn>1477-8939</issn><eissn>1873-0442</eissn><abstract>The aetiologies of fever are poorly understood in sub-Saharan Africa. We aimed to assess the burden of malaria and bacteria in Côte d’Ivoire.
Blood samples from 438 febrile and 346 afebrile people were screened using molecular tools.
Plasmodium falciparum was the most common microorganism associated with fever (46.8% in febrile, 23.4% in afebrile people; p < 0.001). Bacteraemia was detected in 21.7% of febrile people and 12.7% of afebrile people (p = 0.001). Streptococcus pneumoniae was the main cause of bacteraemia (7.1% of febrile and 0.6% of afebrile individuals; p < 0.001). Non-typhoidal Salmonella spp. was detected in 4.5% of febrile people and 1.2% of afebrile individuals (p < 0.001). Salmonella enterica Typhi and S. enterica Paratyphi were only detected in febrile subjects (1.4% and 2.1%), as well as Tropheryma whipplei (0.9%), Streptococcus pyogenes (0.7%), and Plasmodium ovale (4.6%). The prevalence in febrile and afebrile people was similar for Staphylococcus aureus (3.6–4.9%), Rickettsia felis (5.5–6.4%), Mansonella perstans (3.0–3.2%), and Plasmodium malariae (1.6–2.3%). Comorbidities were higher in febrile than in afebrile subjects (10.3% versus 5.5%; p = 0.01); 82% involving P. falciparum. All patients co-infected with P. falciparum and S. pneumoniae were febrile whereas 30% of those infected by P. falciparum alone were not (p = 0.02). Among febrile participants, 30.4% with malaria and 54.7% with bacteraemia had received neither antimalarial nor antibiotic therapy.
Identification of etiologies of acute febrile diseases in sub-Saharan Africa proposes keys to successful treatment and prevention of infectious diseases. Vaccination campaigns may decrease the morbidity of mono- and co-infections by preventable microorganisms.</abstract><cop>Philadelphia</cop><pub>Elsevier Ltd</pub><doi>10.1016/j.tmaid.2021.102105</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-6758-5803</orcidid><orcidid>https://orcid.org/0000-0002-2895-5824</orcidid><orcidid>https://orcid.org/0000-0002-7517-0173</orcidid><orcidid>https://orcid.org/0000-0001-6039-2008</orcidid><orcidid>https://orcid.org/0000-0003-3523-7158</orcidid><orcidid>https://orcid.org/0000-0002-0633-5974</orcidid><orcidid>https://orcid.org/0000-0002-7836-6809</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1477-8939 |
| ispartof | Travel medicine and infectious disease, 2021-09, Vol.43, p.102105-102105, Article 102105 |
| issn | 1477-8939 1873-0442 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_03429328v1 |
| source | Elsevier ScienceDirect Journals |
| subjects | Age Antibiotics Asymptomatic Bacteraemia Bacteria Bacteriology Cardiology and cardiovascular system Côte d’Ivoire Emerging diseases Epidemiology Etiology Fever Human diseases Human health and pathology Illnesses Infectious diseases Life Sciences Malaria Medical diagnosis Microbiology and Parasitology Microorganisms Parasitology Principal components analysis Rural areas Salmonella Salmonella enterica Staphylococcus infections Streptococcus infections Streptococcus pneumoniae Travel medicine Tropical diseases Urban areas Vaccination Vector-borne diseases Virology |
| title | Assessment of the burden of malaria and bacteraemia by retrospective molecular diagnosis in febrile illnesses and first-line anti-infectives in Côte d'Ivoire |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-29T02%3A04%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_hal_p&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Assessment%20of%20the%20burden%20of%20malaria%20and%20bacteraemia%20by%20retrospective%20molecular%20diagnosis%20in%20febrile%20illnesses%20and%20first-line%20anti-infectives%20in%20C%C3%B4te%20d'Ivoire&rft.jtitle=Travel%20medicine%20and%20infectious%20disease&rft.au=Ehounoud,%20Bil%C3%A9%20Cyrille%20Herv%C3%A9&rft.date=2021-09&rft.volume=43&rft.spage=102105&rft.epage=102105&rft.pages=102105-102105&rft.artnum=102105&rft.issn=1477-8939&rft.eissn=1873-0442&rft_id=info:doi/10.1016/j.tmaid.2021.102105&rft_dat=%3Cproquest_hal_p%3E2569046658%3C/proquest_hal_p%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2569046658&rft_id=info:pmid/&rft_els_id=S1477893921001460&rfr_iscdi=true |