Worldwide trends in all-cause mortality of auto-immune systemic diseases between 2001 and 2014
To describe changes in the 2001–2014 mortality of 6 autoimmune systemic diseases (AISDs), namely Systemic Lupus Erythematosus (SLE), Systemic Sclerosis (SSc), Idiopathic Inflammatory Myopathies (IIM), Sjögren's Syndrome (SS), Mixed Connective Tissue Disease (MCTD) and ANCA-associated vasculitis...
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| Veröffentlicht in: | Autoimmunity reviews 2020-06, Vol.19 (6), p.102531, Article 102531 |
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| creator | Scherlinger, Marc Mertz, Philippe Sagez, Flora Meyer, Alain Felten, Renaud Chatelus, Emmanuel Javier, Rose-Marie Sordet, Christelle Martin, Thierry Korganow, Anne-Sophie Guffroy, Aurélien Poindron, Vincent Richez, Christophe Truchetet, Marie-Elise Blanco, Patrick Schaeverbeke, Thierry Sibilia, Jean Devillers, Hervé Arnaud, Laurent |
| description | To describe changes in the 2001–2014 mortality of 6 autoimmune systemic diseases (AISDs), namely Systemic Lupus Erythematosus (SLE), Systemic Sclerosis (SSc), Idiopathic Inflammatory Myopathies (IIM), Sjögren's Syndrome (SS), Mixed Connective Tissue Disease (MCTD) and ANCA-associated vasculitis (AAV) at the country-, continent-, and world-levels.
Mortality data were retrieved from the World Health Organization (WHO) mortality database for each disease, based on ICD-10 codes. We computed age-standardized mortality rate (ASMR) as the estimated number of deaths per million inhabitants and its 95% confidence interval (95%CI). The association between gender, geographical areas and disease-specific mortality was analyzed using multivariate Poisson regression. The 2001–2014 temporal trends were analyzed using Jointpoint software.
In 2014, the worldwide ASMR for SLE was 2.68 (95%CI: 2.62–2.75) deaths/millions inhabitants, 1.46 (1.42–1.51) for SSc, 0.47 (0.44–0.49) for IIM, 0.17 (0.15–0.18) for SS, 0.11 (0.10–0.13) for MCTD and 0.53 (0.50–0.56) for AAV, with ASMRs generally lower in Europe than in North America, Latin America and Asia. Between 2001 and 2014, the worldwide ASMR decreased significantly for SSc (−0.71%/year), IIM (−1.65%/year) and AAV (−1.01%/year; p |
| doi_str_mv | 10.1016/j.autrev.2020.102531 |
| format | Article |
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Mortality data were retrieved from the World Health Organization (WHO) mortality database for each disease, based on ICD-10 codes. We computed age-standardized mortality rate (ASMR) as the estimated number of deaths per million inhabitants and its 95% confidence interval (95%CI). The association between gender, geographical areas and disease-specific mortality was analyzed using multivariate Poisson regression. The 2001–2014 temporal trends were analyzed using Jointpoint software.
In 2014, the worldwide ASMR for SLE was 2.68 (95%CI: 2.62–2.75) deaths/millions inhabitants, 1.46 (1.42–1.51) for SSc, 0.47 (0.44–0.49) for IIM, 0.17 (0.15–0.18) for SS, 0.11 (0.10–0.13) for MCTD and 0.53 (0.50–0.56) for AAV, with ASMRs generally lower in Europe than in North America, Latin America and Asia. Between 2001 and 2014, the worldwide ASMR decreased significantly for SSc (−0.71%/year), IIM (−1.65%/year) and AAV (−1.01%/year; p < .001 for all) and increased for SS (+1.53%/year, p = .01). The worldwide ASMR of SLE decreased significantly between 2001 and 2003 (−6.37%, p < .05) before increasing slightly between 2004 and 2014 (+0.58%, p < .01).
We observed a strong heterogeneity of standardized mortality rates across all countries analyzed for 6 autoimmune diseases. Those results further highlight the impact of world-wide inequities and major gaps in access to care and strategies for diagnosis and management of rare diseases, a crucial finding for world-wide physicians, patient associations and policy makers.
•The age-standardized mortality rate (ASMR) of 6 auto-immune diseases was computed using the WHO mortality database.•The ASMR were generally lower in Europe than in North America, Latin America and Asia.•Between 2001 and 2014, there was a significant worldwide decrease of the ASMR of SSc, IIM & AAVs while it increased for SLE and Sjögren's</description><identifier>ISSN: 1568-9972</identifier><identifier>EISSN: 1568-9972</identifier><identifier>EISSN: 1873-0183</identifier><identifier>DOI: 10.1016/j.autrev.2020.102531</identifier><identifier>PMID: 32234406</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Autoimmune diseases ; Epidemiology ; Immunology ; Life Sciences ; Mortality ; Trends</subject><ispartof>Autoimmunity reviews, 2020-06, Vol.19 (6), p.102531, Article 102531</ispartof><rights>2020</rights><rights>Copyright © 2020. Published by Elsevier B.V.</rights><rights>Attribution - NonCommercial</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c508t-3063f8951f08396163a7bf9149a61b737e22cb37338f71ad2d56ac9759f3cb7b3</citedby><cites>FETCH-LOGICAL-c508t-3063f8951f08396163a7bf9149a61b737e22cb37338f71ad2d56ac9759f3cb7b3</cites><orcidid>0000-0002-4432-4205 ; 0000-0001-8045-0180 ; 0000-0002-3029-8739 ; 0000-0002-7360-6527 ; 0000-0002-5374-3639 ; 0000-0002-9453-5895 ; 0000-0002-6976-643X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1568997220300860$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32234406$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-03415519$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Scherlinger, Marc</creatorcontrib><creatorcontrib>Mertz, Philippe</creatorcontrib><creatorcontrib>Sagez, Flora</creatorcontrib><creatorcontrib>Meyer, Alain</creatorcontrib><creatorcontrib>Felten, Renaud</creatorcontrib><creatorcontrib>Chatelus, Emmanuel</creatorcontrib><creatorcontrib>Javier, Rose-Marie</creatorcontrib><creatorcontrib>Sordet, Christelle</creatorcontrib><creatorcontrib>Martin, Thierry</creatorcontrib><creatorcontrib>Korganow, Anne-Sophie</creatorcontrib><creatorcontrib>Guffroy, Aurélien</creatorcontrib><creatorcontrib>Poindron, Vincent</creatorcontrib><creatorcontrib>Richez, Christophe</creatorcontrib><creatorcontrib>Truchetet, Marie-Elise</creatorcontrib><creatorcontrib>Blanco, Patrick</creatorcontrib><creatorcontrib>Schaeverbeke, Thierry</creatorcontrib><creatorcontrib>Sibilia, Jean</creatorcontrib><creatorcontrib>Devillers, Hervé</creatorcontrib><creatorcontrib>Arnaud, Laurent</creatorcontrib><title>Worldwide trends in all-cause mortality of auto-immune systemic diseases between 2001 and 2014</title><title>Autoimmunity reviews</title><addtitle>Autoimmun Rev</addtitle><description>To describe changes in the 2001–2014 mortality of 6 autoimmune systemic diseases (AISDs), namely Systemic Lupus Erythematosus (SLE), Systemic Sclerosis (SSc), Idiopathic Inflammatory Myopathies (IIM), Sjögren's Syndrome (SS), Mixed Connective Tissue Disease (MCTD) and ANCA-associated vasculitis (AAV) at the country-, continent-, and world-levels.
Mortality data were retrieved from the World Health Organization (WHO) mortality database for each disease, based on ICD-10 codes. We computed age-standardized mortality rate (ASMR) as the estimated number of deaths per million inhabitants and its 95% confidence interval (95%CI). The association between gender, geographical areas and disease-specific mortality was analyzed using multivariate Poisson regression. The 2001–2014 temporal trends were analyzed using Jointpoint software.
In 2014, the worldwide ASMR for SLE was 2.68 (95%CI: 2.62–2.75) deaths/millions inhabitants, 1.46 (1.42–1.51) for SSc, 0.47 (0.44–0.49) for IIM, 0.17 (0.15–0.18) for SS, 0.11 (0.10–0.13) for MCTD and 0.53 (0.50–0.56) for AAV, with ASMRs generally lower in Europe than in North America, Latin America and Asia. Between 2001 and 2014, the worldwide ASMR decreased significantly for SSc (−0.71%/year), IIM (−1.65%/year) and AAV (−1.01%/year; p < .001 for all) and increased for SS (+1.53%/year, p = .01). The worldwide ASMR of SLE decreased significantly between 2001 and 2003 (−6.37%, p < .05) before increasing slightly between 2004 and 2014 (+0.58%, p < .01).
We observed a strong heterogeneity of standardized mortality rates across all countries analyzed for 6 autoimmune diseases. Those results further highlight the impact of world-wide inequities and major gaps in access to care and strategies for diagnosis and management of rare diseases, a crucial finding for world-wide physicians, patient associations and policy makers.
•The age-standardized mortality rate (ASMR) of 6 auto-immune diseases was computed using the WHO mortality database.•The ASMR were generally lower in Europe than in North America, Latin America and Asia.•Between 2001 and 2014, there was a significant worldwide decrease of the ASMR of SSc, IIM & AAVs while it increased for SLE and Sjögren's</description><subject>Autoimmune diseases</subject><subject>Epidemiology</subject><subject>Immunology</subject><subject>Life Sciences</subject><subject>Mortality</subject><subject>Trends</subject><issn>1568-9972</issn><issn>1568-9972</issn><issn>1873-0183</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kMtKAzEUhoMotlbfQCRbF1NzmZlMNkIp3qDgRnFnyCRnMGUuJZm29O3NMFpcucrh8H_nJx9C15TMKaH53Xqut72H3ZwRNqxYxukJmtIsLxIpBTv9M0_QRQhrEjHJ5DmacMZ4mpJ8ij4_Ol_bvbOA47HWBuxarOs6MXobADed73Xt-gPuKhz7usQ1zbYFHA6hh8YZbF0AHSDgEvo9QItZrMG6tXGg6SU6q3Qd4OrnnaH3x4e35XOyen16WS5WiclI0Sec5LwqZEYrUnCZ05xrUVaSplLntBRcAGOm5ILzohJUW2azXBspMllxU4qSz9DtePdL12rjXaP9QXXaqefFSg07wlOaZVTuaMymY9b4LgQP1RGgRA1q1VqNatWgVo1qI3YzYptt2YA9Qr8uY-B-DED86M6BV8E4aA1Y58H0ynbu_4ZvFmSKDg</recordid><startdate>202006</startdate><enddate>202006</enddate><creator>Scherlinger, Marc</creator><creator>Mertz, Philippe</creator><creator>Sagez, Flora</creator><creator>Meyer, Alain</creator><creator>Felten, Renaud</creator><creator>Chatelus, Emmanuel</creator><creator>Javier, Rose-Marie</creator><creator>Sordet, Christelle</creator><creator>Martin, Thierry</creator><creator>Korganow, Anne-Sophie</creator><creator>Guffroy, Aurélien</creator><creator>Poindron, Vincent</creator><creator>Richez, Christophe</creator><creator>Truchetet, Marie-Elise</creator><creator>Blanco, Patrick</creator><creator>Schaeverbeke, Thierry</creator><creator>Sibilia, Jean</creator><creator>Devillers, Hervé</creator><creator>Arnaud, Laurent</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>1XC</scope><scope>VOOES</scope><orcidid>https://orcid.org/0000-0002-4432-4205</orcidid><orcidid>https://orcid.org/0000-0001-8045-0180</orcidid><orcidid>https://orcid.org/0000-0002-3029-8739</orcidid><orcidid>https://orcid.org/0000-0002-7360-6527</orcidid><orcidid>https://orcid.org/0000-0002-5374-3639</orcidid><orcidid>https://orcid.org/0000-0002-9453-5895</orcidid><orcidid>https://orcid.org/0000-0002-6976-643X</orcidid></search><sort><creationdate>202006</creationdate><title>Worldwide trends in all-cause mortality of auto-immune systemic diseases between 2001 and 2014</title><author>Scherlinger, Marc ; 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Mortality data were retrieved from the World Health Organization (WHO) mortality database for each disease, based on ICD-10 codes. We computed age-standardized mortality rate (ASMR) as the estimated number of deaths per million inhabitants and its 95% confidence interval (95%CI). The association between gender, geographical areas and disease-specific mortality was analyzed using multivariate Poisson regression. The 2001–2014 temporal trends were analyzed using Jointpoint software.
In 2014, the worldwide ASMR for SLE was 2.68 (95%CI: 2.62–2.75) deaths/millions inhabitants, 1.46 (1.42–1.51) for SSc, 0.47 (0.44–0.49) for IIM, 0.17 (0.15–0.18) for SS, 0.11 (0.10–0.13) for MCTD and 0.53 (0.50–0.56) for AAV, with ASMRs generally lower in Europe than in North America, Latin America and Asia. Between 2001 and 2014, the worldwide ASMR decreased significantly for SSc (−0.71%/year), IIM (−1.65%/year) and AAV (−1.01%/year; p < .001 for all) and increased for SS (+1.53%/year, p = .01). The worldwide ASMR of SLE decreased significantly between 2001 and 2003 (−6.37%, p < .05) before increasing slightly between 2004 and 2014 (+0.58%, p < .01).
We observed a strong heterogeneity of standardized mortality rates across all countries analyzed for 6 autoimmune diseases. Those results further highlight the impact of world-wide inequities and major gaps in access to care and strategies for diagnosis and management of rare diseases, a crucial finding for world-wide physicians, patient associations and policy makers.
•The age-standardized mortality rate (ASMR) of 6 auto-immune diseases was computed using the WHO mortality database.•The ASMR were generally lower in Europe than in North America, Latin America and Asia.•Between 2001 and 2014, there was a significant worldwide decrease of the ASMR of SSc, IIM & AAVs while it increased for SLE and Sjögren's</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>32234406</pmid><doi>10.1016/j.autrev.2020.102531</doi><orcidid>https://orcid.org/0000-0002-4432-4205</orcidid><orcidid>https://orcid.org/0000-0001-8045-0180</orcidid><orcidid>https://orcid.org/0000-0002-3029-8739</orcidid><orcidid>https://orcid.org/0000-0002-7360-6527</orcidid><orcidid>https://orcid.org/0000-0002-5374-3639</orcidid><orcidid>https://orcid.org/0000-0002-9453-5895</orcidid><orcidid>https://orcid.org/0000-0002-6976-643X</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Elsevier ScienceDirect Journals |
| subjects | Autoimmune diseases Epidemiology Immunology Life Sciences Mortality Trends |
| title | Worldwide trends in all-cause mortality of auto-immune systemic diseases between 2001 and 2014 |
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