Donepezil-ferulic acid hybrids as anti-Alzheimer drugs

Due to the complex nature of Alzheimer's disease, there is a renewed and growing search for multitarget drugs. Donepezil-ferulic acid hybrids (DFAHs) were prepared by the one-pot Ugi-4CR in low-to-moderate yields. DFAHs are potent antioxidant agents, showing oxygen radical absorbance capacity v...

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Veröffentlicht in:	Future medicinal chemistry 2015, Vol.7 (1), p.15-21
Hauptverfasser:	Benchekroun, Mohamed, Ismaili, Lhassane, Pudlo, Marc, Luzet, Vincent, Gharbi, Tijani, Refouvelet, Bernard, Marco-Contelles, José
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - drug therapy Antioxidants - chemical synthesis Antioxidants - chemistry Antioxidants - therapeutic use Butyrylcholinesterase - chemistry Butyrylcholinesterase - metabolism Chemical Sciences Cholinesterase Inhibitors - chemical synthesis Cholinesterase Inhibitors - chemistry Cholinesterase Inhibitors - therapeutic use Coumaric Acids - chemistry Humans Indans - chemistry Piperidines - chemistry
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