Nanovectorization of DNA Through Cells Using Protamine Complexation
Carbon nanotubes (CNT) are currently used as a promising family of nanovectors able to deliver different types of therapeutic molecules. Several applications dealing with CNT used as drug nanocarriers have been developed since their ability to penetrate into the cells has been proved. CNT can thus l...
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| Veröffentlicht in: | The Journal of membrane biology 2016-08, Vol.249 (4), p.493-501 |
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| container_title | The Journal of membrane biology |
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| creator | Boukari, Khaoula Caoduro, Cécile Kacem, Raoudha Skandrani, Nadia Borg, Christophe Boulahdour, Hatem Gharbi, Tijani Delage-Mourroux, Régis Hervouet, Eric Pudlo, Marc Picaud, Fabien |
| description | Carbon nanotubes (CNT) are currently used as a promising family of nanovectors able to deliver different types of therapeutic molecules. Several applications dealing with CNT used as drug nanocarriers have been developed since their ability to penetrate into the cells has been proved. CNT can thus load several active molecules to various cells. In this paper, we will use molecular dynamic simulation to describe theoretically the potential of CNT to transport and deliver DNA through the formation of protamine–DNA–CNT complex. |
| doi_str_mv | 10.1007/s00232-016-9890-5 |
| format | Article |
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Several applications dealing with CNT used as drug nanocarriers have been developed since their ability to penetrate into the cells has been proved. CNT can thus load several active molecules to various cells. In this paper, we will use molecular dynamic simulation to describe theoretically the potential of CNT to transport and deliver DNA through the formation of protamine–DNA–CNT complex.</description><identifier>ISSN: 0022-2631</identifier><identifier>EISSN: 1432-1424</identifier><identifier>DOI: 10.1007/s00232-016-9890-5</identifier><identifier>PMID: 27010822</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Adsorption ; Animals ; Biochemistry ; Biological Transport ; Biomedical and Life Sciences ; Carbon ; Cellular biology ; Chemical Sciences ; DNA - chemistry ; Human Physiology ; Humans ; Life Sciences ; Membranes ; Models, Molecular ; Molecular Conformation ; Molecular Dynamics Simulation ; Nanoparticles - chemistry ; Nanotubes ; Nanotubes, Carbon ; Particle Size ; Protamines - chemistry ; Proteins</subject><ispartof>The Journal of membrane biology, 2016-08, Vol.249 (4), p.493-501</ispartof><rights>Springer Science+Business Media New York 2016</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c439t-bdb52d8616dba5e5093cbd7c66a693bdffbd700be69be807171dc55d7f87b0253</citedby><cites>FETCH-LOGICAL-c439t-bdb52d8616dba5e5093cbd7c66a693bdffbd700be69be807171dc55d7f87b0253</cites><orcidid>0000-0002-0570-394X ; 0000-0002-4841-7812 ; 0000-0002-3575-0253 ; 0000-0002-7692-7457</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00232-016-9890-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00232-016-9890-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27902,27903,41466,42535,51296</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27010822$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-03407844$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Boukari, Khaoula</creatorcontrib><creatorcontrib>Caoduro, Cécile</creatorcontrib><creatorcontrib>Kacem, Raoudha</creatorcontrib><creatorcontrib>Skandrani, Nadia</creatorcontrib><creatorcontrib>Borg, Christophe</creatorcontrib><creatorcontrib>Boulahdour, Hatem</creatorcontrib><creatorcontrib>Gharbi, Tijani</creatorcontrib><creatorcontrib>Delage-Mourroux, Régis</creatorcontrib><creatorcontrib>Hervouet, Eric</creatorcontrib><creatorcontrib>Pudlo, Marc</creatorcontrib><creatorcontrib>Picaud, Fabien</creatorcontrib><title>Nanovectorization of DNA Through Cells Using Protamine Complexation</title><title>The Journal of membrane biology</title><addtitle>J Membrane Biol</addtitle><addtitle>J Membr Biol</addtitle><description>Carbon nanotubes (CNT) are currently used as a promising family of nanovectors able to deliver different types of therapeutic molecules. 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| ispartof | The Journal of membrane biology, 2016-08, Vol.249 (4), p.493-501 |
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| subjects | Adsorption Animals Biochemistry Biological Transport Biomedical and Life Sciences Carbon Cellular biology Chemical Sciences DNA - chemistry Human Physiology Humans Life Sciences Membranes Models, Molecular Molecular Conformation Molecular Dynamics Simulation Nanoparticles - chemistry Nanotubes Nanotubes, Carbon Particle Size Protamines - chemistry Proteins |
| title | Nanovectorization of DNA Through Cells Using Protamine Complexation |
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