The high affinity IgE receptor: a signaling update

•Differences in affinity, valency, concentration of FcεRI-aggregating ligands are translated into distinct signaling outcomes.•Mast cell degranulation implicates a highly complex molecular machinery regulating granule transport and membrane fusion.•Advances made in signaling-dependent cytokine and c...

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Veröffentlicht in:	Current opinion in immunology 2021-10, Vol.72, p.51-58
Hauptverfasser:	Blank, Ulrich, Huang, Hua, Kawakami, Toshiaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens - immunology Cell Degranulation - immunology Cytokines - genetics Cytokines - metabolism Exocytosis - immunology Gene Expression Regulation Humans Immunity Immunoglobulin E - immunology Immunomodulation Life Sciences Protein Binding Receptors, IgE - metabolism Signal Transduction
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