Myotonic dystrophy kinase‐related CDC42‐binding kinase α, a new transferrin receptor type 2‐binding partner, is a regulator of erythropoiesis

Efficient erythropoiesis relies on the expression of the transferrin receptor type 2 (TFR2). In erythroid precursors, TFR2 facilitates the export of the erythropoietin receptor (EPOR) to cell surface, which ensures the survival and proliferation of erythroblasts. Although TFR2 has a crucial role in...

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Veröffentlicht in:	American journal of hematology 2021-04, Vol.96 (4), p.480-492
Hauptverfasser:	Richard, Cyrielle, Viret, Sophie, Cantero Aguilar, Lilia, Lefevre, Carine, Leduc, Marjorie, Faouzi, El Hassan, Azar, Nabih, Lavazec, Catherine, Mayeux, Patrick, Verdier, Frédérique
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals cdc42 GTP-Binding Protein - metabolism Cdc42 protein Cell surface Cells, Cultured CRISPR-Cas Systems Endocytosis Erythroblasts Erythroblasts - cytology Erythroblasts - metabolism Erythroid cells Erythropoiesis Erythropoiesis - physiology Erythropoietin Gene Knockout Techniques Hematology Human health and pathology Humans Immunoprecipitation Internalization Iron - metabolism Life Sciences Mice Myotonic dystrophy Myotonin-Protein Kinase - isolation & purification Myotonin-Protein Kinase - physiology Receptors, Erythropoietin - metabolism Receptors, Transferrin - metabolism RNA Interference RNA, Small Interfering - genetics RNA, Small Interfering - pharmacology Transferrin receptors Transferrins
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