Synthesis, Optimization, Antifungal Activity, Selectivity, and CYP51 Binding of New 2-Aryl-3-azolyl-1-indolyl-propan-2-ols

A series of 2-aryl-3-azolyl-1-indolyl-propan-2-ols was designed as new analogs of fluconazole (FLC) by replacing one of its two triazole moieties by an indole scaffold. Two different chemical approaches were then developed. The first one, in seven steps, involved the synthesis of the key intermediat...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Pharmaceuticals (Basel, Switzerland) Switzerland), 2020, Vol.13 (8)
Hauptverfasser:	Lebouvier, Nicolas, Pagniez, Fabrice, Na, Young Min, Shi, Da, Pinson, Patricia, Marchivie, Mathieu, Guillon, Jean, Hakki, Tarek, Bernhardt, Rita, Wah Yee, Sook, Simons, Claire, Lézé, Marie-Pierre, Hartmann, Rolf W., Mularoni, Angélique, Le Baut, Guillaume, Krimm, Isabelle, Abagyan, Ruben, Le Pape, Patrice, Le Borgne, Marc
Format:	Artikel
Sprache:	eng
Schlagworte:	Life Sciences
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!