Potent Lys Patch-Containing Stapled Peptides Targeting PCSK9

Proprotein convertase subtilisin/kexin type 9 (PCSK9), identified as a regulator of low-density lipoprotein receptor (LDLR), plays a major role in cardiovascular diseases (CVD). Recently, Pep2-8, a small peptide with discrete three-dimensional structure, was found to inhibit the PCSK9/LDLR interacti...

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Veröffentlicht in:	Journal of medicinal chemistry 2021-08, Vol.64 (15), p.10834-10848
Hauptverfasser:	Bourbiaux, Kévin, Legrand, Baptiste, Verdié, Pascal, Mallart, Sergio, Manette, Géraldine, Minoletti, Claire, Stepp, J. David, Prigent, Philippe, Le Bail, Jean-Christophe, Gauzy-Lazo, Laurence, Duclos, Olivier, Martinez, Jean, Amblard, Muriel
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry, Molecular Biology Chemical Sciences Dose-Response Relationship, Drug Hep G2 Cells Humans Life Sciences Lysine Medicinal Chemistry Models, Molecular Molecular Structure PCSK9 Inhibitors Peptides Proprotein Convertase 9 Serine Proteinase Inhibitors Structural Biology Structure-Activity Relationship
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