Poly ethylene glycol (PEG)-Related controllable and sustainable antidiabetic drug delivery systems
Diabetes mellitus is one of the most challenging threats to global public health. To improve the therapy efficacy of antidiabetic drugs, numerous drug delivery systems have been developed. Polyethylene glycol (PEG) is a polymeric family sharing the same skeleton but with different molecular weights...
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Veröffentlicht in: | European journal of medicinal chemistry 2021-05, Vol.217, p.113372-113372, Article 113372 |
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creator | Fu, Yupeng Ding, Ying Zhang, Litao Zhang, Yongmin Liu, Jiang Yu, Peng |
description | Diabetes mellitus is one of the most challenging threats to global public health. To improve the therapy efficacy of antidiabetic drugs, numerous drug delivery systems have been developed. Polyethylene glycol (PEG) is a polymeric family sharing the same skeleton but with different molecular weights which is considered as a promising material for drug delivery. In the delivery of antidiabetic drugs, PEG captures much attention in the designing and preparation of sustainable and controllable release systems due to its unique features including hydrophilicity, biocompatibility and biodegradability. Due to the unique architecture, PEG molecules are also able to shelter delivery systems to decrease their immunogenicity and avoid undesirable enzymolysis. PEG has been applied in plenty of delivery systems such as micelles, vesicles, nanoparticles and hydrogels. In this review, we summarized several commonly used PEG-contained antidiabetic drug delivery systems and emphasized the advantages of stimuli-responsive function in these sustainable and controllable formations.
[Display omitted]
•PEG is one of the most successfully adopted materials to build polymeric antidiabetic drug delivery systems.•Several types of PEG-contained drug delivery systems exhibit controllable and sustainable release profile.•Releasing drug by stimuli responsive means could be achieved via a number of PEG-based drug delivery systems. |
doi_str_mv | 10.1016/j.ejmech.2021.113372 |
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[Display omitted]
•PEG is one of the most successfully adopted materials to build polymeric antidiabetic drug delivery systems.•Several types of PEG-contained drug delivery systems exhibit controllable and sustainable release profile.•Releasing drug by stimuli responsive means could be achieved via a number of PEG-based drug delivery systems.</description><identifier>ISSN: 0223-5234</identifier><identifier>EISSN: 1768-3254</identifier><identifier>DOI: 10.1016/j.ejmech.2021.113372</identifier><identifier>PMID: 33744689</identifier><language>eng</language><publisher>France: Elsevier Masson SAS</publisher><subject>Antidiabetic ; Diabetes Mellitus ; Drug Carriers ; Drug delivery system ; Drug Delivery Systems ; Humans ; Hypoglycemic Agents ; Life Sciences ; Micelles ; Molecular Structure ; PEG ; Pharmaceutical sciences ; Polyethylene Glycols ; Stimulating responsive release ; Sustainable release</subject><ispartof>European journal of medicinal chemistry, 2021-05, Vol.217, p.113372-113372, Article 113372</ispartof><rights>2021 Elsevier Masson SAS</rights><rights>Copyright © 2021 Elsevier Masson SAS. All rights reserved.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-1667ffd13c847f7bcb71d84fd3c1e426eee44b74d0cfbec1d251ef0b3c3db7c13</citedby><cites>FETCH-LOGICAL-c442t-1667ffd13c847f7bcb71d84fd3c1e426eee44b74d0cfbec1d251ef0b3c3db7c13</cites><orcidid>0000-0002-7821-3124 ; 0000-0001-8493-5812</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ejmech.2021.113372$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33744689$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.sorbonne-universite.fr/hal-03369183$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Fu, Yupeng</creatorcontrib><creatorcontrib>Ding, Ying</creatorcontrib><creatorcontrib>Zhang, Litao</creatorcontrib><creatorcontrib>Zhang, Yongmin</creatorcontrib><creatorcontrib>Liu, Jiang</creatorcontrib><creatorcontrib>Yu, Peng</creatorcontrib><title>Poly ethylene glycol (PEG)-Related controllable and sustainable antidiabetic drug delivery systems</title><title>European journal of medicinal chemistry</title><addtitle>Eur J Med Chem</addtitle><description>Diabetes mellitus is one of the most challenging threats to global public health. To improve the therapy efficacy of antidiabetic drugs, numerous drug delivery systems have been developed. Polyethylene glycol (PEG) is a polymeric family sharing the same skeleton but with different molecular weights which is considered as a promising material for drug delivery. In the delivery of antidiabetic drugs, PEG captures much attention in the designing and preparation of sustainable and controllable release systems due to its unique features including hydrophilicity, biocompatibility and biodegradability. Due to the unique architecture, PEG molecules are also able to shelter delivery systems to decrease their immunogenicity and avoid undesirable enzymolysis. PEG has been applied in plenty of delivery systems such as micelles, vesicles, nanoparticles and hydrogels. In this review, we summarized several commonly used PEG-contained antidiabetic drug delivery systems and emphasized the advantages of stimuli-responsive function in these sustainable and controllable formations.
[Display omitted]
•PEG is one of the most successfully adopted materials to build polymeric antidiabetic drug delivery systems.•Several types of PEG-contained drug delivery systems exhibit controllable and sustainable release profile.•Releasing drug by stimuli responsive means could be achieved via a number of PEG-based drug delivery systems.</description><subject>Antidiabetic</subject><subject>Diabetes Mellitus</subject><subject>Drug Carriers</subject><subject>Drug delivery system</subject><subject>Drug Delivery Systems</subject><subject>Humans</subject><subject>Hypoglycemic Agents</subject><subject>Life Sciences</subject><subject>Micelles</subject><subject>Molecular Structure</subject><subject>PEG</subject><subject>Pharmaceutical sciences</subject><subject>Polyethylene Glycols</subject><subject>Stimulating responsive release</subject><subject>Sustainable release</subject><issn>0223-5234</issn><issn>1768-3254</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kU1r3DAQhkVpabZp_0EpOiYHb_Vl2XsphJAmhYWG0p6FPsZZLbKVSvKC_31svM2xp2GGZ96XmRehz5RsKaHy63ELxx7sYcsIo1tKOW_YG7ShjWwrzmrxFm0IY7yqGRcX6EPOR0JILQl5jy5mVgjZ7jbIPMYwYSiHKcAA-ClMNgZ89Xh3f139gqALOGzjUFIMQZsAWA8O5zEX7YdzX7zz2kDxFrs0PmEHwZ8gTThPuUCfP6J3nQ4ZPp3rJfrz_e737UO1_3n_4_ZmX1khWKmolE3XOcptK5quMdY01LWic9xSEEwCgBCmEY7YzoCljtUUOmK45c40lvJLdL3qHnRQz8n3Ok0qaq8ebvZqmRHO5Y62_LSwVyv7nOLfEXJRvc8W5hsHiGNWrCZc1rtWLKhYUZtizgm6V21K1JKEOqo1CbUkodYk5rUvZ4fR9OBel_69fga-rQDMPzl5SCpbD4MF5xPYolz0_3d4AQ-ZnGo</recordid><startdate>20210505</startdate><enddate>20210505</enddate><creator>Fu, Yupeng</creator><creator>Ding, Ying</creator><creator>Zhang, Litao</creator><creator>Zhang, Yongmin</creator><creator>Liu, Jiang</creator><creator>Yu, Peng</creator><general>Elsevier Masson SAS</general><general>Elsevier</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope><orcidid>https://orcid.org/0000-0002-7821-3124</orcidid><orcidid>https://orcid.org/0000-0001-8493-5812</orcidid></search><sort><creationdate>20210505</creationdate><title>Poly ethylene glycol (PEG)-Related controllable and sustainable antidiabetic drug delivery systems</title><author>Fu, Yupeng ; Ding, Ying ; Zhang, Litao ; Zhang, Yongmin ; Liu, Jiang ; Yu, Peng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-1667ffd13c847f7bcb71d84fd3c1e426eee44b74d0cfbec1d251ef0b3c3db7c13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Antidiabetic</topic><topic>Diabetes Mellitus</topic><topic>Drug Carriers</topic><topic>Drug delivery system</topic><topic>Drug Delivery Systems</topic><topic>Humans</topic><topic>Hypoglycemic Agents</topic><topic>Life Sciences</topic><topic>Micelles</topic><topic>Molecular Structure</topic><topic>PEG</topic><topic>Pharmaceutical sciences</topic><topic>Polyethylene Glycols</topic><topic>Stimulating responsive release</topic><topic>Sustainable release</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fu, Yupeng</creatorcontrib><creatorcontrib>Ding, Ying</creatorcontrib><creatorcontrib>Zhang, Litao</creatorcontrib><creatorcontrib>Zhang, Yongmin</creatorcontrib><creatorcontrib>Liu, Jiang</creatorcontrib><creatorcontrib>Yu, Peng</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><jtitle>European journal of medicinal chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fu, Yupeng</au><au>Ding, Ying</au><au>Zhang, Litao</au><au>Zhang, Yongmin</au><au>Liu, Jiang</au><au>Yu, Peng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Poly ethylene glycol (PEG)-Related controllable and sustainable antidiabetic drug delivery systems</atitle><jtitle>European journal of medicinal chemistry</jtitle><addtitle>Eur J Med Chem</addtitle><date>2021-05-05</date><risdate>2021</risdate><volume>217</volume><spage>113372</spage><epage>113372</epage><pages>113372-113372</pages><artnum>113372</artnum><issn>0223-5234</issn><eissn>1768-3254</eissn><abstract>Diabetes mellitus is one of the most challenging threats to global public health. To improve the therapy efficacy of antidiabetic drugs, numerous drug delivery systems have been developed. Polyethylene glycol (PEG) is a polymeric family sharing the same skeleton but with different molecular weights which is considered as a promising material for drug delivery. In the delivery of antidiabetic drugs, PEG captures much attention in the designing and preparation of sustainable and controllable release systems due to its unique features including hydrophilicity, biocompatibility and biodegradability. Due to the unique architecture, PEG molecules are also able to shelter delivery systems to decrease their immunogenicity and avoid undesirable enzymolysis. PEG has been applied in plenty of delivery systems such as micelles, vesicles, nanoparticles and hydrogels. In this review, we summarized several commonly used PEG-contained antidiabetic drug delivery systems and emphasized the advantages of stimuli-responsive function in these sustainable and controllable formations.
[Display omitted]
•PEG is one of the most successfully adopted materials to build polymeric antidiabetic drug delivery systems.•Several types of PEG-contained drug delivery systems exhibit controllable and sustainable release profile.•Releasing drug by stimuli responsive means could be achieved via a number of PEG-based drug delivery systems.</abstract><cop>France</cop><pub>Elsevier Masson SAS</pub><pmid>33744689</pmid><doi>10.1016/j.ejmech.2021.113372</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-7821-3124</orcidid><orcidid>https://orcid.org/0000-0001-8493-5812</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Antidiabetic Diabetes Mellitus Drug Carriers Drug delivery system Drug Delivery Systems Humans Hypoglycemic Agents Life Sciences Micelles Molecular Structure PEG Pharmaceutical sciences Polyethylene Glycols Stimulating responsive release Sustainable release |
title | Poly ethylene glycol (PEG)-Related controllable and sustainable antidiabetic drug delivery systems |
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