Whole-genome mapping of small-molecule targets for cancer medicine

Cancers display intratumoral and intertumoral heterogeneity, which poses challenges to small-molecule intervention. Studying drug responses on a whole-genome and transcriptome level using next-generation sequencing has revolutionized our understanding of how small molecules intervene in cells, which...

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Veröffentlicht in:Current opinion in chemical biology 2020-06, Vol.56, p.42-50
Hauptverfasser: Solier, Stéphanie, Müller, Sebastian, Rodriguez, Raphaël
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container_title Current opinion in chemical biology
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creator Solier, Stéphanie
Müller, Sebastian
Rodriguez, Raphaël
description Cancers display intratumoral and intertumoral heterogeneity, which poses challenges to small-molecule intervention. Studying drug responses on a whole-genome and transcriptome level using next-generation sequencing has revolutionized our understanding of how small molecules intervene in cells, which helps us to study and potentially predict treatment outcomes. Some small molecules act directly at the genomic level by targeting DNA or chromatin proteins. Here, we review recent advances in establishing whole-genome and transcriptome maps of small-molecule targets, comprising chromatin components or downstream events. We also describe recent advances in studying drug responses using single-cell RNA and DNA sequencing. Furthermore, we discuss how this fundamental research can be taken forward to devise innovative personalized treatment modalities. [Display omitted]
doi_str_mv 10.1016/j.cbpa.2019.12.005
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subjects Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Cancer
Chem-seq
ChiP-seq
Chromosome Mapping - methods
DNA-Binding Proteins - chemistry
DNA-Binding Proteins - metabolism
G-Quadruplexes
High-Throughput Nucleotide Sequencing
Humans
Life Sciences
Molecular Targeted Therapy
Neoplasms - drug therapy
Neoplasms - genetics
NGS
Nucleic Acids - chemistry
Nucleic Acids - metabolism
RNA-seq
Sequencing
Single-Cell Analysis
Small molecule
Small Molecule Libraries - chemistry
Small Molecule Libraries - pharmacology
Transcriptome - genetics
title Whole-genome mapping of small-molecule targets for cancer medicine
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