Whole-genome mapping of small-molecule targets for cancer medicine
Cancers display intratumoral and intertumoral heterogeneity, which poses challenges to small-molecule intervention. Studying drug responses on a whole-genome and transcriptome level using next-generation sequencing has revolutionized our understanding of how small molecules intervene in cells, which...
Gespeichert in:
Veröffentlicht in: | Current opinion in chemical biology 2020-06, Vol.56, p.42-50 |
---|---|
Hauptverfasser: | , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 50 |
---|---|
container_issue | |
container_start_page | 42 |
container_title | Current opinion in chemical biology |
container_volume | 56 |
creator | Solier, Stéphanie Müller, Sebastian Rodriguez, Raphaël |
description | Cancers display intratumoral and intertumoral heterogeneity, which poses challenges to small-molecule intervention. Studying drug responses on a whole-genome and transcriptome level using next-generation sequencing has revolutionized our understanding of how small molecules intervene in cells, which helps us to study and potentially predict treatment outcomes. Some small molecules act directly at the genomic level by targeting DNA or chromatin proteins. Here, we review recent advances in establishing whole-genome and transcriptome maps of small-molecule targets, comprising chromatin components or downstream events. We also describe recent advances in studying drug responses using single-cell RNA and DNA sequencing. Furthermore, we discuss how this fundamental research can be taken forward to devise innovative personalized treatment modalities.
[Display omitted] |
doi_str_mv | 10.1016/j.cbpa.2019.12.005 |
format | Article |
fullrecord | <record><control><sourceid>proquest_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_hal_03365498v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1367593119301498</els_id><sourcerecordid>2345507357</sourcerecordid><originalsourceid>FETCH-LOGICAL-c434t-c5e17c35d0bfa477450b76fc3799aa82869f1531c8535c783ad493d7271f4fe03</originalsourceid><addsrcrecordid>eNp9kLtOxDAQRS0E4v0DFCglFAl-xrFEA4iXtBINiNLyOuPFqyQOdnYl_h6vFiipZjRz7i0OQmcEVwST-mpZ2floKoqJqgitMBY76JA0UpWYY7qbd1bLUihGDtBRSkuMcU0bsY8OGFGyqak4RLfvH6GDcgFD6KHozTj6YVEEV6TedF3Z56dddVBMJi5gSoULsbBmsBCLHlpv_QAnaM-ZLsHpzzxGbw_3r3dP5ezl8fnuZlZazvhUWgFEWiZaPHeGS8kFnsvaWSaVMqahTa0cEYzYRjBhZcNMyxVrJZXEcQeYHaPLbe-H6fQYfW_ilw7G66ebmd7cMGO14KpZk8xebNkxhs8VpEn3PlnoOjNAWCVNGRcCSyZkRukWtTGkFMH9dROsN571Um88641nTajOnnPo_Kd_Nc8e_iK_YjNwvQUgG1l7iDpZD9lb6yPYSbfB_9f_DY-IjHM</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2345507357</pqid></control><display><type>article</type><title>Whole-genome mapping of small-molecule targets for cancer medicine</title><source>Elsevier ScienceDirect Journals Complete - AutoHoldings</source><source>MEDLINE</source><creator>Solier, Stéphanie ; Müller, Sebastian ; Rodriguez, Raphaël</creator><creatorcontrib>Solier, Stéphanie ; Müller, Sebastian ; Rodriguez, Raphaël</creatorcontrib><description>Cancers display intratumoral and intertumoral heterogeneity, which poses challenges to small-molecule intervention. Studying drug responses on a whole-genome and transcriptome level using next-generation sequencing has revolutionized our understanding of how small molecules intervene in cells, which helps us to study and potentially predict treatment outcomes. Some small molecules act directly at the genomic level by targeting DNA or chromatin proteins. Here, we review recent advances in establishing whole-genome and transcriptome maps of small-molecule targets, comprising chromatin components or downstream events. We also describe recent advances in studying drug responses using single-cell RNA and DNA sequencing. Furthermore, we discuss how this fundamental research can be taken forward to devise innovative personalized treatment modalities.
[Display omitted]</description><identifier>ISSN: 1367-5931</identifier><identifier>EISSN: 1879-0402</identifier><identifier>EISSN: 1367-5931</identifier><identifier>DOI: 10.1016/j.cbpa.2019.12.005</identifier><identifier>PMID: 31978625</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Antineoplastic Agents - chemistry ; Antineoplastic Agents - pharmacology ; Cancer ; Chem-seq ; ChiP-seq ; Chromosome Mapping - methods ; DNA-Binding Proteins - chemistry ; DNA-Binding Proteins - metabolism ; G-Quadruplexes ; High-Throughput Nucleotide Sequencing ; Humans ; Life Sciences ; Molecular Targeted Therapy ; Neoplasms - drug therapy ; Neoplasms - genetics ; NGS ; Nucleic Acids - chemistry ; Nucleic Acids - metabolism ; RNA-seq ; Sequencing ; Single-Cell Analysis ; Small molecule ; Small Molecule Libraries - chemistry ; Small Molecule Libraries - pharmacology ; Transcriptome - genetics</subject><ispartof>Current opinion in chemical biology, 2020-06, Vol.56, p.42-50</ispartof><rights>2019 Elsevier Ltd</rights><rights>Copyright © 2019 Elsevier Ltd. All rights reserved.</rights><rights>Attribution - NonCommercial</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c434t-c5e17c35d0bfa477450b76fc3799aa82869f1531c8535c783ad493d7271f4fe03</citedby><cites>FETCH-LOGICAL-c434t-c5e17c35d0bfa477450b76fc3799aa82869f1531c8535c783ad493d7271f4fe03</cites><orcidid>0000-0003-3867-4644 ; 0000-0002-3423-5364 ; 0000-0001-7668-446X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.cbpa.2019.12.005$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,778,782,883,3539,27907,27908,45978</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31978625$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-03365498$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Solier, Stéphanie</creatorcontrib><creatorcontrib>Müller, Sebastian</creatorcontrib><creatorcontrib>Rodriguez, Raphaël</creatorcontrib><title>Whole-genome mapping of small-molecule targets for cancer medicine</title><title>Current opinion in chemical biology</title><addtitle>Curr Opin Chem Biol</addtitle><description>Cancers display intratumoral and intertumoral heterogeneity, which poses challenges to small-molecule intervention. Studying drug responses on a whole-genome and transcriptome level using next-generation sequencing has revolutionized our understanding of how small molecules intervene in cells, which helps us to study and potentially predict treatment outcomes. Some small molecules act directly at the genomic level by targeting DNA or chromatin proteins. Here, we review recent advances in establishing whole-genome and transcriptome maps of small-molecule targets, comprising chromatin components or downstream events. We also describe recent advances in studying drug responses using single-cell RNA and DNA sequencing. Furthermore, we discuss how this fundamental research can be taken forward to devise innovative personalized treatment modalities.
[Display omitted]</description><subject>Antineoplastic Agents - chemistry</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Cancer</subject><subject>Chem-seq</subject><subject>ChiP-seq</subject><subject>Chromosome Mapping - methods</subject><subject>DNA-Binding Proteins - chemistry</subject><subject>DNA-Binding Proteins - metabolism</subject><subject>G-Quadruplexes</subject><subject>High-Throughput Nucleotide Sequencing</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Molecular Targeted Therapy</subject><subject>Neoplasms - drug therapy</subject><subject>Neoplasms - genetics</subject><subject>NGS</subject><subject>Nucleic Acids - chemistry</subject><subject>Nucleic Acids - metabolism</subject><subject>RNA-seq</subject><subject>Sequencing</subject><subject>Single-Cell Analysis</subject><subject>Small molecule</subject><subject>Small Molecule Libraries - chemistry</subject><subject>Small Molecule Libraries - pharmacology</subject><subject>Transcriptome - genetics</subject><issn>1367-5931</issn><issn>1879-0402</issn><issn>1367-5931</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kLtOxDAQRS0E4v0DFCglFAl-xrFEA4iXtBINiNLyOuPFqyQOdnYl_h6vFiipZjRz7i0OQmcEVwST-mpZ2floKoqJqgitMBY76JA0UpWYY7qbd1bLUihGDtBRSkuMcU0bsY8OGFGyqak4RLfvH6GDcgFD6KHozTj6YVEEV6TedF3Z56dddVBMJi5gSoULsbBmsBCLHlpv_QAnaM-ZLsHpzzxGbw_3r3dP5ezl8fnuZlZazvhUWgFEWiZaPHeGS8kFnsvaWSaVMqahTa0cEYzYRjBhZcNMyxVrJZXEcQeYHaPLbe-H6fQYfW_ilw7G66ebmd7cMGO14KpZk8xebNkxhs8VpEn3PlnoOjNAWCVNGRcCSyZkRukWtTGkFMH9dROsN571Um88641nTajOnnPo_Kd_Nc8e_iK_YjNwvQUgG1l7iDpZD9lb6yPYSbfB_9f_DY-IjHM</recordid><startdate>202006</startdate><enddate>202006</enddate><creator>Solier, Stéphanie</creator><creator>Müller, Sebastian</creator><creator>Rodriguez, Raphaël</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope><orcidid>https://orcid.org/0000-0003-3867-4644</orcidid><orcidid>https://orcid.org/0000-0002-3423-5364</orcidid><orcidid>https://orcid.org/0000-0001-7668-446X</orcidid></search><sort><creationdate>202006</creationdate><title>Whole-genome mapping of small-molecule targets for cancer medicine</title><author>Solier, Stéphanie ; Müller, Sebastian ; Rodriguez, Raphaël</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c434t-c5e17c35d0bfa477450b76fc3799aa82869f1531c8535c783ad493d7271f4fe03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Antineoplastic Agents - chemistry</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Cancer</topic><topic>Chem-seq</topic><topic>ChiP-seq</topic><topic>Chromosome Mapping - methods</topic><topic>DNA-Binding Proteins - chemistry</topic><topic>DNA-Binding Proteins - metabolism</topic><topic>G-Quadruplexes</topic><topic>High-Throughput Nucleotide Sequencing</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Molecular Targeted Therapy</topic><topic>Neoplasms - drug therapy</topic><topic>Neoplasms - genetics</topic><topic>NGS</topic><topic>Nucleic Acids - chemistry</topic><topic>Nucleic Acids - metabolism</topic><topic>RNA-seq</topic><topic>Sequencing</topic><topic>Single-Cell Analysis</topic><topic>Small molecule</topic><topic>Small Molecule Libraries - chemistry</topic><topic>Small Molecule Libraries - pharmacology</topic><topic>Transcriptome - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Solier, Stéphanie</creatorcontrib><creatorcontrib>Müller, Sebastian</creatorcontrib><creatorcontrib>Rodriguez, Raphaël</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><jtitle>Current opinion in chemical biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Solier, Stéphanie</au><au>Müller, Sebastian</au><au>Rodriguez, Raphaël</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Whole-genome mapping of small-molecule targets for cancer medicine</atitle><jtitle>Current opinion in chemical biology</jtitle><addtitle>Curr Opin Chem Biol</addtitle><date>2020-06</date><risdate>2020</risdate><volume>56</volume><spage>42</spage><epage>50</epage><pages>42-50</pages><issn>1367-5931</issn><eissn>1879-0402</eissn><eissn>1367-5931</eissn><abstract>Cancers display intratumoral and intertumoral heterogeneity, which poses challenges to small-molecule intervention. Studying drug responses on a whole-genome and transcriptome level using next-generation sequencing has revolutionized our understanding of how small molecules intervene in cells, which helps us to study and potentially predict treatment outcomes. Some small molecules act directly at the genomic level by targeting DNA or chromatin proteins. Here, we review recent advances in establishing whole-genome and transcriptome maps of small-molecule targets, comprising chromatin components or downstream events. We also describe recent advances in studying drug responses using single-cell RNA and DNA sequencing. Furthermore, we discuss how this fundamental research can be taken forward to devise innovative personalized treatment modalities.
[Display omitted]</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>31978625</pmid><doi>10.1016/j.cbpa.2019.12.005</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-3867-4644</orcidid><orcidid>https://orcid.org/0000-0002-3423-5364</orcidid><orcidid>https://orcid.org/0000-0001-7668-446X</orcidid><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 1367-5931 |
ispartof | Current opinion in chemical biology, 2020-06, Vol.56, p.42-50 |
issn | 1367-5931 1879-0402 1367-5931 |
language | eng |
recordid | cdi_hal_primary_oai_HAL_hal_03365498v1 |
source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
subjects | Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Cancer Chem-seq ChiP-seq Chromosome Mapping - methods DNA-Binding Proteins - chemistry DNA-Binding Proteins - metabolism G-Quadruplexes High-Throughput Nucleotide Sequencing Humans Life Sciences Molecular Targeted Therapy Neoplasms - drug therapy Neoplasms - genetics NGS Nucleic Acids - chemistry Nucleic Acids - metabolism RNA-seq Sequencing Single-Cell Analysis Small molecule Small Molecule Libraries - chemistry Small Molecule Libraries - pharmacology Transcriptome - genetics |
title | Whole-genome mapping of small-molecule targets for cancer medicine |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-16T14%3A36%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_hal_p&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Whole-genome%20mapping%20of%20small-molecule%20targets%20for%20cancer%20medicine&rft.jtitle=Current%20opinion%20in%20chemical%20biology&rft.au=Solier,%20St%C3%A9phanie&rft.date=2020-06&rft.volume=56&rft.spage=42&rft.epage=50&rft.pages=42-50&rft.issn=1367-5931&rft.eissn=1879-0402&rft_id=info:doi/10.1016/j.cbpa.2019.12.005&rft_dat=%3Cproquest_hal_p%3E2345507357%3C/proquest_hal_p%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2345507357&rft_id=info:pmid/31978625&rft_els_id=S1367593119301498&rfr_iscdi=true |