Allosteric Inhibition of HER2 by Moesin-Mimicking Compounds Targets HER2-Positive Cancers and Brain Metastases

Therapies targeting the tyrosine kinase receptor HER2 have significantly improved survival of patients with HER2 cancer. However, both and acquired resistance remain a challenge, particularly in the brain metastatic setting. Here we report that, unlike other HER tyrosine kinase receptors, HER2 posse...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2021-11, Vol.81 (21), p.5464-5476
Hauptverfasser:	Faure, Camille, Djerbi-Bouillié, Rym, Domingot, Anaïs, Bouzinba-Segard, Haniaa, Taouji, Saïd, Saidi, Yanis, Bernard, Sandra, Carallis, Floriane, Rothe-Walther, Romy, Lenormand, Jean-Luc, Chevet, Eric, Bourdoulous, Sandrine
Format:	Artikel
Sprache:	eng
Schlagworte:	Allosteric Regulation Animals Apoptosis Biomimetics - methods Brain Neoplasms - drug therapy Brain Neoplasms - metabolism Brain Neoplasms - secondary Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell Proliferation Clopenthixol - pharmacology Dopamine Antagonists - pharmacology Female Gene Expression Regulation, Neoplastic Humans Life Sciences Mice Mice, Nude Microfilament Proteins - genetics Microfilament Proteins - metabolism Receptor, ErbB-2 - antagonists & inhibitors Receptor, ErbB-2 - genetics Receptor, ErbB-2 - metabolism Tumor Cells, Cultured Xenograft Model Antitumor Assays
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