Overexpression of chloride importer NKCC1 contributes to the sensory-affective and sociability phenotype of rats following neonatal maternal separation

•Maternal separation alters central expression and function of chloride transporters.•Maternal separation induces anxiety-like symptoms and a lack of social preference.•Phenotypic alterations are associated with a pro-inflammatory state.•Neonatal administration of bumetanide or oxytocin normalizes t...

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Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2021-02, Vol.92, p.193-202
Hauptverfasser:	Gazzo, Géraldine, Melchior, Meggane, Caussaint, Andréa, Gieré, Clémence, Lelièvre, Vincent, Poisbeau, Pierrick
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal biology Anxiety Chloride homeostasis Life Sciences Neonatal maternal separation Oxytocin Pain Sociability
Online-Zugang:	Volltext
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