The puzzle of quality of life in schizophrenia: putting the pieces together with the FACE-SZ cohort
BackgroundThe determinants of quality of life (QoL) in schizophrenia are largely debated, mainly due to methodological discrepancies and divergence about the concepts concerned. As most studies have investigated bi- or tri-variate models, a multivariate model accounting for simultaneous potential me...
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| Veröffentlicht in: | Psychological medicine 2022-06, Vol.52 (8), p.1501-1508 |
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| creator | Ehrminger, Mickael Roux, Paul Urbach, Mathieu André, Myrtille Aouizerate, Bruno Berna, Fabrice Bohec, Anne-Lise Capdevielle, Delphine Chéreau, Isabelle Clauss, Julie Dubertret, Caroline Dubreucq, Julien Fond, Guillaume Honciuc, Roxana-Mihaela Lançon, Christophe Laouamri, Hakim Leigner, Sylvain Mallet, Jasmina Misdrahi, David Pignon, Baptiste Rey, Romain Schürhoff, Franck Passerieux, Christine Brunet-Gouet, Eric |
| description | BackgroundThe determinants of quality of life (QoL) in schizophrenia are largely debated, mainly due to methodological discrepancies and divergence about the concepts concerned. As most studies have investigated bi- or tri-variate models, a multivariate model accounting for simultaneous potential mediations is necessary to have a comprehensive view of the determinants of QOL. We sought to estimate the associations between cognitive reserve, cognition, functioning, insight, depression, schizophrenic symptoms, and QoL in schizophrenia and their potential mediation relationships.MethodsWe used structural equation modeling with mediation analyses to test a model based on existing literature in a sample of 776 patients with schizophrenia from the FondaMental Foundation FACE-SZ cohort.ResultsOur model showed a good fit to the data. We found better functioning to be positively associated with a better QoL, whereas better cognition, better insight, higher levels of depression, and schizophrenic symptoms were associated with a lower QoL in our sample. Cognitive reserve is not directly linked to QoL, but indirectly in a negative manner via cognition. We confirm the negative relationship between cognition and subjective QoL which was previously evidenced by other studies; moreover, this relationship seems to be robust as it survived in our multivariate model. It was not explained by insight as some suggested, thus the mechanism at stake remains to be explained.ConclusionThe pathways to subjective QoL in schizophrenia are complex and the determinants largely influence each other. Longitudinal studies are warranted to confirm these cross-sectional findings. |
| doi_str_mv | 10.1017/S0033291720003311 |
| format | Article |
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As most studies have investigated bi- or tri-variate models, a multivariate model accounting for simultaneous potential mediations is necessary to have a comprehensive view of the determinants of QOL. We sought to estimate the associations between cognitive reserve, cognition, functioning, insight, depression, schizophrenic symptoms, and QoL in schizophrenia and their potential mediation relationships.MethodsWe used structural equation modeling with mediation analyses to test a model based on existing literature in a sample of 776 patients with schizophrenia from the FondaMental Foundation FACE-SZ cohort.ResultsOur model showed a good fit to the data. We found better functioning to be positively associated with a better QoL, whereas better cognition, better insight, higher levels of depression, and schizophrenic symptoms were associated with a lower QoL in our sample. Cognitive reserve is not directly linked to QoL, but indirectly in a negative manner via cognition. We confirm the negative relationship between cognition and subjective QoL which was previously evidenced by other studies; moreover, this relationship seems to be robust as it survived in our multivariate model. It was not explained by insight as some suggested, thus the mechanism at stake remains to be explained.ConclusionThe pathways to subjective QoL in schizophrenia are complex and the determinants largely influence each other. Longitudinal studies are warranted to confirm these cross-sectional findings.</description><identifier>ISSN: 0033-2917</identifier><identifier>EISSN: 1469-8978</identifier><identifier>DOI: 10.1017/S0033291720003311</identifier><identifier>PMID: 32962773</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Cognition ; Cognition & reasoning ; Cognitive ability ; Discrepancies ; Human health and pathology ; Life Sciences ; Mental depression ; Mental disorders ; Neurons and Cognition ; Original Article ; Psychiatrics and mental health ; Psychology and behavior ; Quality of life ; Schizophrenia ; Stigma ; Structural equation modeling ; Variables</subject><ispartof>Psychological medicine, 2022-06, Vol.52 (8), p.1501-1508</ispartof><rights>Copyright © The Author(s) 2020. Published by Cambridge University Press</rights><rights>Copyright</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-3fbfab3ea67867634720c40023859968a32104386285c06074756f483ee161cb3</citedby><cites>FETCH-LOGICAL-c384t-3fbfab3ea67867634720c40023859968a32104386285c06074756f483ee161cb3</cites><orcidid>0000-0002-9158-7120 ; 0000-0003-4079-4194 ; 0000-0003-4130-1590 ; 0000-0002-7146-8554 ; 0000-0001-5050-1362 ; 0000-0003-0526-3136 ; 0000-0002-6118-0629 ; 0000-0002-4603-3575 ; 0000-0002-7092-7747 ; 0000-0003-3249-2030 ; 0000-0003-0321-4189 ; 0000-0002-2732-406X ; 0000-0002-0661-5781 ; 0000-0003-1146-3206 ; 0000-0002-3784-7817</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0033291720003311/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,230,314,780,784,885,12846,27924,27925,30999,55628</link.rule.ids><backlink>$$Uhttps://hal.umontpellier.fr/hal-03338446$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Ehrminger, Mickael</creatorcontrib><creatorcontrib>Roux, Paul</creatorcontrib><creatorcontrib>Urbach, Mathieu</creatorcontrib><creatorcontrib>André, Myrtille</creatorcontrib><creatorcontrib>Aouizerate, Bruno</creatorcontrib><creatorcontrib>Berna, Fabrice</creatorcontrib><creatorcontrib>Bohec, Anne-Lise</creatorcontrib><creatorcontrib>Capdevielle, Delphine</creatorcontrib><creatorcontrib>Chéreau, Isabelle</creatorcontrib><creatorcontrib>Clauss, Julie</creatorcontrib><creatorcontrib>Dubertret, Caroline</creatorcontrib><creatorcontrib>Dubreucq, Julien</creatorcontrib><creatorcontrib>Fond, Guillaume</creatorcontrib><creatorcontrib>Honciuc, Roxana-Mihaela</creatorcontrib><creatorcontrib>Lançon, Christophe</creatorcontrib><creatorcontrib>Laouamri, Hakim</creatorcontrib><creatorcontrib>Leigner, Sylvain</creatorcontrib><creatorcontrib>Mallet, Jasmina</creatorcontrib><creatorcontrib>Misdrahi, David</creatorcontrib><creatorcontrib>Pignon, Baptiste</creatorcontrib><creatorcontrib>Rey, Romain</creatorcontrib><creatorcontrib>Schürhoff, Franck</creatorcontrib><creatorcontrib>Passerieux, Christine</creatorcontrib><creatorcontrib>Brunet-Gouet, Eric</creatorcontrib><creatorcontrib>Members of the FACE-SCZ Group</creatorcontrib><title>The puzzle of quality of life in schizophrenia: putting the pieces together with the FACE-SZ cohort</title><title>Psychological medicine</title><addtitle>Psychol. Med</addtitle><description>BackgroundThe determinants of quality of life (QoL) in schizophrenia are largely debated, mainly due to methodological discrepancies and divergence about the concepts concerned. As most studies have investigated bi- or tri-variate models, a multivariate model accounting for simultaneous potential mediations is necessary to have a comprehensive view of the determinants of QOL. We sought to estimate the associations between cognitive reserve, cognition, functioning, insight, depression, schizophrenic symptoms, and QoL in schizophrenia and their potential mediation relationships.MethodsWe used structural equation modeling with mediation analyses to test a model based on existing literature in a sample of 776 patients with schizophrenia from the FondaMental Foundation FACE-SZ cohort.ResultsOur model showed a good fit to the data. We found better functioning to be positively associated with a better QoL, whereas better cognition, better insight, higher levels of depression, and schizophrenic symptoms were associated with a lower QoL in our sample. Cognitive reserve is not directly linked to QoL, but indirectly in a negative manner via cognition. We confirm the negative relationship between cognition and subjective QoL which was previously evidenced by other studies; moreover, this relationship seems to be robust as it survived in our multivariate model. It was not explained by insight as some suggested, thus the mechanism at stake remains to be explained.ConclusionThe pathways to subjective QoL in schizophrenia are complex and the determinants largely influence each other. Longitudinal studies are warranted to confirm these cross-sectional findings.</description><subject>Cognition</subject><subject>Cognition & reasoning</subject><subject>Cognitive ability</subject><subject>Discrepancies</subject><subject>Human health and pathology</subject><subject>Life Sciences</subject><subject>Mental depression</subject><subject>Mental disorders</subject><subject>Neurons and Cognition</subject><subject>Original Article</subject><subject>Psychiatrics and mental health</subject><subject>Psychology and behavior</subject><subject>Quality of life</subject><subject>Schizophrenia</subject><subject>Stigma</subject><subject>Structural equation 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puzzle of quality of life in schizophrenia: putting the pieces together with the FACE-SZ cohort</title><author>Ehrminger, Mickael ; Roux, Paul ; Urbach, Mathieu ; André, Myrtille ; Aouizerate, Bruno ; Berna, Fabrice ; Bohec, Anne-Lise ; Capdevielle, Delphine ; Chéreau, Isabelle ; Clauss, Julie ; Dubertret, Caroline ; Dubreucq, Julien ; Fond, Guillaume ; Honciuc, Roxana-Mihaela ; Lançon, Christophe ; Laouamri, Hakim ; Leigner, Sylvain ; Mallet, Jasmina ; Misdrahi, David ; Pignon, Baptiste ; Rey, Romain ; Schürhoff, Franck ; Passerieux, Christine ; Brunet-Gouet, Eric</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-3fbfab3ea67867634720c40023859968a32104386285c06074756f483ee161cb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Cognition</topic><topic>Cognition & reasoning</topic><topic>Cognitive ability</topic><topic>Discrepancies</topic><topic>Human health and pathology</topic><topic>Life Sciences</topic><topic>Mental depression</topic><topic>Mental disorders</topic><topic>Neurons and Cognition</topic><topic>Original Article</topic><topic>Psychiatrics and mental health</topic><topic>Psychology and behavior</topic><topic>Quality of life</topic><topic>Schizophrenia</topic><topic>Stigma</topic><topic>Structural equation modeling</topic><topic>Variables</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ehrminger, Mickael</creatorcontrib><creatorcontrib>Roux, Paul</creatorcontrib><creatorcontrib>Urbach, Mathieu</creatorcontrib><creatorcontrib>André, Myrtille</creatorcontrib><creatorcontrib>Aouizerate, Bruno</creatorcontrib><creatorcontrib>Berna, Fabrice</creatorcontrib><creatorcontrib>Bohec, Anne-Lise</creatorcontrib><creatorcontrib>Capdevielle, Delphine</creatorcontrib><creatorcontrib>Chéreau, Isabelle</creatorcontrib><creatorcontrib>Clauss, Julie</creatorcontrib><creatorcontrib>Dubertret, 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Roxana-Mihaela</au><au>Lançon, Christophe</au><au>Laouamri, Hakim</au><au>Leigner, Sylvain</au><au>Mallet, Jasmina</au><au>Misdrahi, David</au><au>Pignon, Baptiste</au><au>Rey, Romain</au><au>Schürhoff, Franck</au><au>Passerieux, Christine</au><au>Brunet-Gouet, Eric</au><aucorp>Members of the FACE-SCZ Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The puzzle of quality of life in schizophrenia: putting the pieces together with the FACE-SZ cohort</atitle><jtitle>Psychological medicine</jtitle><addtitle>Psychol. Med</addtitle><date>2022-06-01</date><risdate>2022</risdate><volume>52</volume><issue>8</issue><spage>1501</spage><epage>1508</epage><pages>1501-1508</pages><issn>0033-2917</issn><eissn>1469-8978</eissn><abstract>BackgroundThe determinants of quality of life (QoL) in schizophrenia are largely debated, mainly due to methodological discrepancies and divergence about the concepts concerned. As most studies have investigated bi- or tri-variate models, a multivariate model accounting for simultaneous potential mediations is necessary to have a comprehensive view of the determinants of QOL. We sought to estimate the associations between cognitive reserve, cognition, functioning, insight, depression, schizophrenic symptoms, and QoL in schizophrenia and their potential mediation relationships.MethodsWe used structural equation modeling with mediation analyses to test a model based on existing literature in a sample of 776 patients with schizophrenia from the FondaMental Foundation FACE-SZ cohort.ResultsOur model showed a good fit to the data. We found better functioning to be positively associated with a better QoL, whereas better cognition, better insight, higher levels of depression, and schizophrenic symptoms were associated with a lower QoL in our sample. Cognitive reserve is not directly linked to QoL, but indirectly in a negative manner via cognition. We confirm the negative relationship between cognition and subjective QoL which was previously evidenced by other studies; moreover, this relationship seems to be robust as it survived in our multivariate model. It was not explained by insight as some suggested, thus the mechanism at stake remains to be explained.ConclusionThe pathways to subjective QoL in schizophrenia are complex and the determinants largely influence each other. Longitudinal studies are warranted to confirm these cross-sectional findings.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>32962773</pmid><doi>10.1017/S0033291720003311</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-9158-7120</orcidid><orcidid>https://orcid.org/0000-0003-4079-4194</orcidid><orcidid>https://orcid.org/0000-0003-4130-1590</orcidid><orcidid>https://orcid.org/0000-0002-7146-8554</orcidid><orcidid>https://orcid.org/0000-0001-5050-1362</orcidid><orcidid>https://orcid.org/0000-0003-0526-3136</orcidid><orcidid>https://orcid.org/0000-0002-6118-0629</orcidid><orcidid>https://orcid.org/0000-0002-4603-3575</orcidid><orcidid>https://orcid.org/0000-0002-7092-7747</orcidid><orcidid>https://orcid.org/0000-0003-3249-2030</orcidid><orcidid>https://orcid.org/0000-0003-0321-4189</orcidid><orcidid>https://orcid.org/0000-0002-2732-406X</orcidid><orcidid>https://orcid.org/0000-0002-0661-5781</orcidid><orcidid>https://orcid.org/0000-0003-1146-3206</orcidid><orcidid>https://orcid.org/0000-0002-3784-7817</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0033-2917 |
| ispartof | Psychological medicine, 2022-06, Vol.52 (8), p.1501-1508 |
| issn | 0033-2917 1469-8978 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_03338446v1 |
| source | Applied Social Sciences Index & Abstracts (ASSIA); Cambridge Journals Online |
| subjects | Cognition Cognition & reasoning Cognitive ability Discrepancies Human health and pathology Life Sciences Mental depression Mental disorders Neurons and Cognition Original Article Psychiatrics and mental health Psychology and behavior Quality of life Schizophrenia Stigma Structural equation modeling Variables |
| title | The puzzle of quality of life in schizophrenia: putting the pieces together with the FACE-SZ cohort |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T17%3A09%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_hal_p&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20puzzle%20of%20quality%20of%20life%20in%20schizophrenia:%20putting%20the%20pieces%20together%20with%20the%20FACE-SZ%20cohort&rft.jtitle=Psychological%20medicine&rft.au=Ehrminger,%20Mickael&rft.aucorp=Members%20of%20the%20FACE-SCZ%20Group&rft.date=2022-06-01&rft.volume=52&rft.issue=8&rft.spage=1501&rft.epage=1508&rft.pages=1501-1508&rft.issn=0033-2917&rft.eissn=1469-8978&rft_id=info:doi/10.1017/S0033291720003311&rft_dat=%3Cproquest_hal_p%3E2445437391%3C/proquest_hal_p%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2679827867&rft_id=info:pmid/32962773&rft_cupid=10_1017_S0033291720003311&rfr_iscdi=true |