Process improvement in amino acid N-carboxyanhydride synthesis by N-carbamoyl amino acid nitrosation

Amino acid N-carboxyanhydrides (NCA), convenient monomer for polypeptide synthesis, are easily prepared in high purity as the result of N-carbamoyl amino acids (CAA) nitrosation by gaseous NOx (4:1 NO + O₂ mixture, or NOCl) in toluene. Removal of polar side products is then efficiently carried out d...

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Veröffentlicht in:	Amino acids 2009-02, Vol.36 (2), p.341-347
Hauptverfasser:	Lagrille, Olivier, Danger, Grégoire, Boiteau, Laurent, Rossi, Jean-Christophe, Taillades, Jacques
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Amino Acids - chemistry Analytical Chemistry Anhydrides - chemical synthesis Biochemical Engineering Biochemistry Biomedical and Life Sciences Chemical Sciences Crystallization Life Sciences Monomers Neurobiology Nitrosation Original Article Polymerization Polypeptides Proteomics Purity Synthesis Toluene
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