Expression of hepatitis C virus NS5A natural mutants in a hepatocytic cell line inhibits the antiviral effect of interferon in a PKR-independent manner

The impact of hepatitis C virus NS5A protein mutations on interferon alfa (IFN-α) signaling pathway, cell proliferation, and viability is an important issue that is still under debate. We have therefore combined transient and stable expression in a human hepatocytic cell line (Huh7) of 3 full-length...

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Veröffentlicht in:Hepatology (Baltimore, Md.) Md.), 2001-06, Vol.33 (6), p.1503-1511
Hauptverfasser: Podevin, Philippe, Sabile, Abdelmajid, Gajardo, Rodrigo, Delhem, Nadira, Abadie, Annie, Lozach, Pierre-Yves, Beretta, Laura, Bréchot, Christian
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Sprache:eng
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