Functional abdominal pain disorders and patient- and parent-reported outcomes in children with inflammatory bowel disease in remission
Chronic abdominal pain occurs frequently in pediatric patients with inflammatory bowel disease (IBD) in remission. To assess the prevalence and factors associated with Functional Abdominal Pain Disorders among IBD children in remission (IBD-FAPD). Patients with IBD for > 1 year, in clinical remis...
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| creator | Tran, Léa Chantal Bridoux-Henno, Laure Gastineau, Swellen Dabadie, Alain Carré, Emilie Hugot, Jean-Pierre Martinez-Vinson, Christine Mosca, Alexis Coopman, Stéphanie Lamireau, Thierry Enaud, Raphaël Clouzeau, Haude Bertrand, Valérie Pigneur, Bénédicte Ruemmele, Frank Degas, Vanessa Breton, Anne Mas, Emmanuel Lacotte, Édouard Chaillou-Legault, Emilie Caron, Nicolas Languepin, Jane Willot, Stéphanie Bouazza, Ahlem Spyckerelle, Claire Dimitrov, Georges Thomassin, Nadège Djeddi, Djamal Vanrenterghem, Audrey Grandjean, Camille Viala, Jérôme Dupont-Lucas, Claire |
| description | Chronic abdominal pain occurs frequently in pediatric patients with inflammatory bowel disease (IBD) in remission.
To assess the prevalence and factors associated with Functional Abdominal Pain Disorders among IBD children in remission (IBD-FAPD).
Patients with IBD for > 1 year, in clinical remission for ≥ 3 months were recruited from a National IBD network. IBD-FAPDs were assessed using the Rome III questionnaire criteria. Patient- or parent- reported outcomes were assessed.
Among 102 included patients, 57 (56%) were boys, mean age (DS) was 15.0 (± 2.0) years and 75 (74%) had Crohn's disease. Twenty-two patients (22%) had at least one Functional Gastrointestinal Disorder among which 17 had at least one IBD-FAPD. Past severity of disease or treatments received and level of remission were not significantly associated with IBD-FAPD. Patients with IBD-FAPD reported more fatigue (peds-FACIT-F: 35.9 ± 9.8 vs. 43.0 ± 6.9, p = 0.01) and a lower HR-QoL (IMPACT III: 76.5 ± 9.6 vs. 81.6 ± 9.2, p = 0.04) than patients without FAPD, and their parents had higher levels of State and Trait anxiety than the other parents.
Prevalence of IBD-FAPD was 17%. IBD-FAPD was not associated with past severity of disease, but with fatigue and lower HR-QoL. |
| doi_str_mv | 10.1016/j.dld.2021.05.034 |
| format | Article |
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To assess the prevalence and factors associated with Functional Abdominal Pain Disorders among IBD children in remission (IBD-FAPD).
Patients with IBD for > 1 year, in clinical remission for ≥ 3 months were recruited from a National IBD network. IBD-FAPDs were assessed using the Rome III questionnaire criteria. Patient- or parent- reported outcomes were assessed.
Among 102 included patients, 57 (56%) were boys, mean age (DS) was 15.0 (± 2.0) years and 75 (74%) had Crohn's disease. Twenty-two patients (22%) had at least one Functional Gastrointestinal Disorder among which 17 had at least one IBD-FAPD. Past severity of disease or treatments received and level of remission were not significantly associated with IBD-FAPD. Patients with IBD-FAPD reported more fatigue (peds-FACIT-F: 35.9 ± 9.8 vs. 43.0 ± 6.9, p = 0.01) and a lower HR-QoL (IMPACT III: 76.5 ± 9.6 vs. 81.6 ± 9.2, p = 0.04) than patients without FAPD, and their parents had higher levels of State and Trait anxiety than the other parents.
Prevalence of IBD-FAPD was 17%. IBD-FAPD was not associated with past severity of disease, but with fatigue and lower HR-QoL.</description><identifier>ISSN: 1590-8658</identifier><identifier>EISSN: 1878-3562</identifier><identifier>DOI: 10.1016/j.dld.2021.05.034</identifier><identifier>PMID: 34187767</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Abdominal pain ; Abdominal Pain - etiology ; Abdominal Pain - psychology ; Adolescent ; Anxiety ; Case-Control Studies ; Cross-Sectional Studies ; Fatigue ; Fatigue - etiology ; Fatigue - psychology ; Female ; Humans ; Inflammatory bowel disease ; Inflammatory Bowel Diseases - complications ; Inflammatory Bowel Diseases - psychology ; Life Sciences ; Male ; Paediatrics ; Parents - psychology ; Patient Reported Outcome Measures ; Quality of Life ; Remission Induction ; Santé publique et épidémiologie ; Severity of Illness Index</subject><ispartof>Digestive and liver disease, 2021-10, Vol.53 (10), p.1268-1275</ispartof><rights>2021 The Authors</rights><rights>Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.</rights><rights>Attribution</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c430t-824cc61943c68faf8dc18b8381ee9d441d01e9d81beef72f259cfcc6dc00da2b3</citedby><cites>FETCH-LOGICAL-c430t-824cc61943c68faf8dc18b8381ee9d441d01e9d81beef72f259cfcc6dc00da2b3</cites><orcidid>0000-0002-5777-8492 ; 0000-0002-9513-0275 ; 0000-0002-7355-6515</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.dld.2021.05.034$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34187767$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-03325068$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Tran, Léa Chantal</creatorcontrib><creatorcontrib>Bridoux-Henno, Laure</creatorcontrib><creatorcontrib>Gastineau, Swellen</creatorcontrib><creatorcontrib>Dabadie, Alain</creatorcontrib><creatorcontrib>Carré, Emilie</creatorcontrib><creatorcontrib>Hugot, Jean-Pierre</creatorcontrib><creatorcontrib>Martinez-Vinson, Christine</creatorcontrib><creatorcontrib>Mosca, Alexis</creatorcontrib><creatorcontrib>Coopman, Stéphanie</creatorcontrib><creatorcontrib>Lamireau, Thierry</creatorcontrib><creatorcontrib>Enaud, Raphaël</creatorcontrib><creatorcontrib>Clouzeau, Haude</creatorcontrib><creatorcontrib>Bertrand, Valérie</creatorcontrib><creatorcontrib>Pigneur, Bénédicte</creatorcontrib><creatorcontrib>Ruemmele, Frank</creatorcontrib><creatorcontrib>Degas, Vanessa</creatorcontrib><creatorcontrib>Breton, Anne</creatorcontrib><creatorcontrib>Mas, Emmanuel</creatorcontrib><creatorcontrib>Lacotte, Édouard</creatorcontrib><creatorcontrib>Chaillou-Legault, Emilie</creatorcontrib><creatorcontrib>Caron, Nicolas</creatorcontrib><creatorcontrib>Languepin, Jane</creatorcontrib><creatorcontrib>Willot, Stéphanie</creatorcontrib><creatorcontrib>Bouazza, Ahlem</creatorcontrib><creatorcontrib>Spyckerelle, Claire</creatorcontrib><creatorcontrib>Dimitrov, Georges</creatorcontrib><creatorcontrib>Thomassin, Nadège</creatorcontrib><creatorcontrib>Djeddi, Djamal</creatorcontrib><creatorcontrib>Vanrenterghem, Audrey</creatorcontrib><creatorcontrib>Grandjean, Camille</creatorcontrib><creatorcontrib>Viala, Jérôme</creatorcontrib><creatorcontrib>Dupont-Lucas, Claire</creatorcontrib><title>Functional abdominal pain disorders and patient- and parent-reported outcomes in children with inflammatory bowel disease in remission</title><title>Digestive and liver disease</title><addtitle>Dig Liver Dis</addtitle><description>Chronic abdominal pain occurs frequently in pediatric patients with inflammatory bowel disease (IBD) in remission.
To assess the prevalence and factors associated with Functional Abdominal Pain Disorders among IBD children in remission (IBD-FAPD).
Patients with IBD for > 1 year, in clinical remission for ≥ 3 months were recruited from a National IBD network. IBD-FAPDs were assessed using the Rome III questionnaire criteria. Patient- or parent- reported outcomes were assessed.
Among 102 included patients, 57 (56%) were boys, mean age (DS) was 15.0 (± 2.0) years and 75 (74%) had Crohn's disease. Twenty-two patients (22%) had at least one Functional Gastrointestinal Disorder among which 17 had at least one IBD-FAPD. Past severity of disease or treatments received and level of remission were not significantly associated with IBD-FAPD. Patients with IBD-FAPD reported more fatigue (peds-FACIT-F: 35.9 ± 9.8 vs. 43.0 ± 6.9, p = 0.01) and a lower HR-QoL (IMPACT III: 76.5 ± 9.6 vs. 81.6 ± 9.2, p = 0.04) than patients without FAPD, and their parents had higher levels of State and Trait anxiety than the other parents.
Prevalence of IBD-FAPD was 17%. IBD-FAPD was not associated with past severity of disease, but with fatigue and lower HR-QoL.</description><subject>Abdominal pain</subject><subject>Abdominal Pain - etiology</subject><subject>Abdominal Pain - psychology</subject><subject>Adolescent</subject><subject>Anxiety</subject><subject>Case-Control Studies</subject><subject>Cross-Sectional Studies</subject><subject>Fatigue</subject><subject>Fatigue - etiology</subject><subject>Fatigue - psychology</subject><subject>Female</subject><subject>Humans</subject><subject>Inflammatory bowel disease</subject><subject>Inflammatory Bowel Diseases - complications</subject><subject>Inflammatory Bowel Diseases - psychology</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Paediatrics</subject><subject>Parents - psychology</subject><subject>Patient Reported Outcome Measures</subject><subject>Quality of Life</subject><subject>Remission Induction</subject><subject>Santé publique et épidémiologie</subject><subject>Severity of Illness Index</subject><issn>1590-8658</issn><issn>1878-3562</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1u3CAUhVHUKn_tA3RTedks7PI_WF1FUZNUGqmbdo0wXGsYYTMFnCgv0Ocu1kyy7IrD5TsHxEHoE8EdwUR-3XcuuI5iSjosOsz4GbokaqNaJiR9V7XocaukUBfoKuc9rqAU-BxdMF6xjdxcor_3y2yLj7MJjRlcnPyqDsbPjfM5JgcpN2Z2dVQ8zKU9bdKqExxiKuCauBQbJ8hNtdmdD64eN8--7OpgDGaaTInppRniM4Q1F0yGlU0w-Zzr7R_Q-9GEDB9P6zX6ff_9191ju_358OPudttaznBpFeXWStJzZqUazaicJWpQTBGA3nFOHCZVKDIAjBs6UtHbsTqcxdgZOrBrdHPM3ZmgD8lPJr3oaLx-vN3qdYYZowJL9UQq--XIHlL8s0Auuj7WQghmhrhkTQWXvcKU84qSI2pTzDnB-JZNsF6r0ntdq9JrVRqLesvq-XyKX4YJ3JvjtZsKfDsCUD_kyUPS2dYKLDifwBbtov9P_D_lw6cD</recordid><startdate>20211001</startdate><enddate>20211001</enddate><creator>Tran, Léa Chantal</creator><creator>Bridoux-Henno, Laure</creator><creator>Gastineau, Swellen</creator><creator>Dabadie, Alain</creator><creator>Carré, Emilie</creator><creator>Hugot, Jean-Pierre</creator><creator>Martinez-Vinson, Christine</creator><creator>Mosca, Alexis</creator><creator>Coopman, Stéphanie</creator><creator>Lamireau, Thierry</creator><creator>Enaud, Raphaël</creator><creator>Clouzeau, Haude</creator><creator>Bertrand, Valérie</creator><creator>Pigneur, Bénédicte</creator><creator>Ruemmele, Frank</creator><creator>Degas, Vanessa</creator><creator>Breton, Anne</creator><creator>Mas, Emmanuel</creator><creator>Lacotte, Édouard</creator><creator>Chaillou-Legault, Emilie</creator><creator>Caron, Nicolas</creator><creator>Languepin, Jane</creator><creator>Willot, Stéphanie</creator><creator>Bouazza, Ahlem</creator><creator>Spyckerelle, Claire</creator><creator>Dimitrov, Georges</creator><creator>Thomassin, Nadège</creator><creator>Djeddi, Djamal</creator><creator>Vanrenterghem, Audrey</creator><creator>Grandjean, Camille</creator><creator>Viala, Jérôme</creator><creator>Dupont-Lucas, Claire</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope><orcidid>https://orcid.org/0000-0002-5777-8492</orcidid><orcidid>https://orcid.org/0000-0002-9513-0275</orcidid><orcidid>https://orcid.org/0000-0002-7355-6515</orcidid></search><sort><creationdate>20211001</creationdate><title>Functional abdominal pain disorders and patient- and parent-reported outcomes in children with inflammatory bowel disease in remission</title><author>Tran, Léa Chantal ; Bridoux-Henno, Laure ; Gastineau, Swellen ; Dabadie, Alain ; Carré, Emilie ; Hugot, Jean-Pierre ; Martinez-Vinson, Christine ; Mosca, Alexis ; Coopman, Stéphanie ; Lamireau, Thierry ; Enaud, Raphaël ; Clouzeau, Haude ; Bertrand, Valérie ; Pigneur, Bénédicte ; Ruemmele, Frank ; Degas, Vanessa ; Breton, Anne ; Mas, Emmanuel ; Lacotte, Édouard ; Chaillou-Legault, Emilie ; Caron, Nicolas ; Languepin, Jane ; Willot, Stéphanie ; Bouazza, Ahlem ; Spyckerelle, Claire ; Dimitrov, Georges ; Thomassin, Nadège ; Djeddi, Djamal ; Vanrenterghem, Audrey ; Grandjean, Camille ; Viala, Jérôme ; Dupont-Lucas, Claire</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c430t-824cc61943c68faf8dc18b8381ee9d441d01e9d81beef72f259cfcc6dc00da2b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Abdominal pain</topic><topic>Abdominal Pain - 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Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><jtitle>Digestive and liver disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tran, Léa Chantal</au><au>Bridoux-Henno, Laure</au><au>Gastineau, Swellen</au><au>Dabadie, Alain</au><au>Carré, Emilie</au><au>Hugot, Jean-Pierre</au><au>Martinez-Vinson, Christine</au><au>Mosca, Alexis</au><au>Coopman, Stéphanie</au><au>Lamireau, Thierry</au><au>Enaud, Raphaël</au><au>Clouzeau, Haude</au><au>Bertrand, Valérie</au><au>Pigneur, Bénédicte</au><au>Ruemmele, Frank</au><au>Degas, Vanessa</au><au>Breton, Anne</au><au>Mas, Emmanuel</au><au>Lacotte, Édouard</au><au>Chaillou-Legault, Emilie</au><au>Caron, Nicolas</au><au>Languepin, Jane</au><au>Willot, Stéphanie</au><au>Bouazza, Ahlem</au><au>Spyckerelle, Claire</au><au>Dimitrov, Georges</au><au>Thomassin, Nadège</au><au>Djeddi, Djamal</au><au>Vanrenterghem, Audrey</au><au>Grandjean, Camille</au><au>Viala, Jérôme</au><au>Dupont-Lucas, Claire</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Functional abdominal pain disorders and patient- and parent-reported outcomes in children with inflammatory bowel disease in remission</atitle><jtitle>Digestive and liver disease</jtitle><addtitle>Dig Liver Dis</addtitle><date>2021-10-01</date><risdate>2021</risdate><volume>53</volume><issue>10</issue><spage>1268</spage><epage>1275</epage><pages>1268-1275</pages><issn>1590-8658</issn><eissn>1878-3562</eissn><abstract>Chronic abdominal pain occurs frequently in pediatric patients with inflammatory bowel disease (IBD) in remission.
To assess the prevalence and factors associated with Functional Abdominal Pain Disorders among IBD children in remission (IBD-FAPD).
Patients with IBD for > 1 year, in clinical remission for ≥ 3 months were recruited from a National IBD network. IBD-FAPDs were assessed using the Rome III questionnaire criteria. Patient- or parent- reported outcomes were assessed.
Among 102 included patients, 57 (56%) were boys, mean age (DS) was 15.0 (± 2.0) years and 75 (74%) had Crohn's disease. Twenty-two patients (22%) had at least one Functional Gastrointestinal Disorder among which 17 had at least one IBD-FAPD. Past severity of disease or treatments received and level of remission were not significantly associated with IBD-FAPD. Patients with IBD-FAPD reported more fatigue (peds-FACIT-F: 35.9 ± 9.8 vs. 43.0 ± 6.9, p = 0.01) and a lower HR-QoL (IMPACT III: 76.5 ± 9.6 vs. 81.6 ± 9.2, p = 0.04) than patients without FAPD, and their parents had higher levels of State and Trait anxiety than the other parents.
Prevalence of IBD-FAPD was 17%. IBD-FAPD was not associated with past severity of disease, but with fatigue and lower HR-QoL.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>34187767</pmid><doi>10.1016/j.dld.2021.05.034</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-5777-8492</orcidid><orcidid>https://orcid.org/0000-0002-9513-0275</orcidid><orcidid>https://orcid.org/0000-0002-7355-6515</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1590-8658 |
| ispartof | Digestive and liver disease, 2021-10, Vol.53 (10), p.1268-1275 |
| issn | 1590-8658 1878-3562 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_03325068v1 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Abdominal pain Abdominal Pain - etiology Abdominal Pain - psychology Adolescent Anxiety Case-Control Studies Cross-Sectional Studies Fatigue Fatigue - etiology Fatigue - psychology Female Humans Inflammatory bowel disease Inflammatory Bowel Diseases - complications Inflammatory Bowel Diseases - psychology Life Sciences Male Paediatrics Parents - psychology Patient Reported Outcome Measures Quality of Life Remission Induction Santé publique et épidémiologie Severity of Illness Index |
| title | Functional abdominal pain disorders and patient- and parent-reported outcomes in children with inflammatory bowel disease in remission |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-19T06%3A13%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_hal_p&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Functional%20abdominal%20pain%20disorders%20and%20patient-%20and%20parent-reported%20outcomes%20in%20children%20with%20inflammatory%20bowel%20disease%20in%20remission&rft.jtitle=Digestive%20and%20liver%20disease&rft.au=Tran,%20L%C3%A9a%20Chantal&rft.date=2021-10-01&rft.volume=53&rft.issue=10&rft.spage=1268&rft.epage=1275&rft.pages=1268-1275&rft.issn=1590-8658&rft.eissn=1878-3562&rft_id=info:doi/10.1016/j.dld.2021.05.034&rft_dat=%3Cproquest_hal_p%3E2546980244%3C/proquest_hal_p%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2546980244&rft_id=info:pmid/34187767&rft_els_id=S159086582100308X&rfr_iscdi=true |