Synthesis of acyclic nucleoside phosphonates targeting flavin-dependent thymidylate synthase in Mycobacterium tuberculosis

[Display omitted] Flavin-Dependent Thymidylate Synthase (FDTS) encoded by ThyX gene was discovered as a new class of thymidylate synthase involved in the de novo synthesis of dTMP named only in 30 % of human pathogenic bacteria. This target was pursed for the development of new antibacterial agents...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2021-09, Vol.46, p.116351-116351, Article 116351
Hauptverfasser:	Biteau, Nicolas G., Roy, Vincent, Lambry, Jean-Christophe, Becker, Hubert F., Myllykallio, Hannu, Agrofoglio, Luigi A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyclic nucleoside phosphonate Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Chemical Sciences Dose-Response Relationship, Drug Flavin-dependent thymidylate synthase Medicinal Chemistry Microbial Sensitivity Tests Molecular Structure Mycobacterium tuberculosis - drug effects Mycobacterium tuberculosis - enzymology Nucleosides - chemical synthesis Nucleosides - chemistry Nucleosides - pharmacology Ruthenium-catalyzed cross-metathesis Sonogashira cross-coupling Structure-Activity Relationship Thymidylate Synthase - antagonists & inhibitors Thymidylate Synthase - metabolism
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