A dual role for hepatocyte-intrinsic canonical NF-κB signaling in virus control

Hepatic innate immune control of viral infections has largely been attributed to Kupffer cells, the liver-resident macrophages. However, hepatocytes, the parenchymal cells of the liver, also possess potent immunological functions in addition to their known metabolic functions. Owing to their abundan...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of hepatology 2020-05, Vol.72 (5), p.960-975
Hauptverfasser:	Namineni, Sukumar, O'Connor, Tracy, Faure-Dupuy, Suzanne, Johansen, Pål, Riedl, Tobias, Liu, Kaijing, Xu, Haifeng, Singh, Indrabahadur, Shinde, Prashant, Li, Fanghui, Pandyra, Aleksandra, Sharma, Piyush, Ringelhan, Marc, Muschaweckh, Andreas, Borst, Katharina, Blank, Patrick, Lampl, Sandra, Neuhaus, Katharina, Durantel, David, Farhat, Rayan, Weber, Achim, Lenggenhager, Daniela, Kündig, Thomas M., Staeheli, Peter, Protzer, Ulrike, Wohlleber, Dirk, Holzmann, Bernhard, Binder, Marco, Breuhahn, Kai, Assmus, Lisa Mareike, Nattermann, Jacob, Abdullah, Zeinab, Rolland, Maude, Dejardin, Emmanuel, Lang, Philipp A., Lang, Karl S., Karin, Michael, Lucifora, Julie, Kalinke, Ulrich, Knolle, Percy A., Heikenwalder, Mathias
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive immunity CD8 antigen Cytotoxic T cells Hepatocytes Immune clearance Immunology Infections Innate immune responses Interferon Interferon-stimulated genes Kupffer cells Life Sciences Liver Lymphocytes T Macrophages Microbiology and Parasitology Myeloid cells NF-kB signaling NF-κB protein PRRs Replication Toll-like receptors Tumor necrosis factor receptors Viral infections Virology α-Interferon
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!