The role of G-Quadruplex DNA in Paraspeckle formation in cancer

Paraspeckles are RNA–protein structures within the nucleus of mammalian cells, capable of orchestrating various biochemical processes. An overexpression of the architectural component of paraspeckles, a long non-coding RNA called NEAT1 (Nuclear Enriched Abundant Transcript 1), has been linked to a v...

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Veröffentlicht in:	Biochimie 2021-11, Vol.190, p.124-131
Hauptverfasser:	Bhatt, Uditi, Kretzmann, Amy L., Guédin, Aurore, Ou, Arnold, Kobelke, Simon, Bond, Charles S., Evans, Cameron W., Hurley, Laurence H., Mergny, Jean-Louis, Iyer, K. Swaminathan, Fox, Archa H., Smith, Nicole M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry, Molecular Biology Breast cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism Cell Line, Tumor Cellular Biology G-quadruplex G-Quadruplexes G-quartet G-tetraplex G4 DNA Humans Life Sciences NEAT1 NEAT1_2 Neoplasms - genetics Neoplasms - metabolism Paraspeckles Paraspeckles - genetics Paraspeckles - metabolism RNA, Long Noncoding - chemistry RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism
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