Management, functional outcomes and survival in a French multicentric series of 118 adult patients with cerebellar glioblastoma
Purpose To analyze the outcomes and predictors in a large series of cerebellar glioblastomas in order to guide patient management. Methods The French brain tumor database and the Club de Neuro-Oncologie of the Société Française de Neurochirurgie retrospectively identified adult patients with cerebel...
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| Veröffentlicht in: | Journal of cancer research and clinical oncology 2021-06, Vol.147 (6), p.1843-1856 |
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| creator | Picart, Thiébaud Meyronet, David Pallud, Johan Dumot, Chloé Metellus, Philippe Zouaoui, Sonia Berhouma, Moncef Ducray, François Bauchet, Luc Guyotat, Jacques |
| description | Purpose
To analyze the outcomes and predictors in a large series of cerebellar glioblastomas in order to guide patient management.
Methods
The French brain tumor database and the Club de Neuro-Oncologie of the Société Française de Neurochirurgie retrospectively identified adult patients with cerebellar glioblastoma diagnosed between 2003 and 2017. Diagnosis was confirmed by a centralized neuropathological review.
Results
Data from 118 cerebellar glioblastoma patients were analyzed (mean age 55.9 years, 55.1% males). The clinical presentation associated raised intracranial pressure (50.8%), static cerebellar syndrome (68.6%), kinetic cerebellar syndrome (49.2%) and/or cranial nerve disorders (17.8%). Glioblastomas were hemispheric (55.9%), vermian (14.4%) or both (29.7%). Hydrocephalus was present in 49 patients (41.5%). Histologically, tumors corresponded either to IDH-wild-type or to K27-mutant glioblastomas.
Surgery consisted of total (12.7%), subtotal (35.6%), partial resection (33.9%) or biopsy (17.8%). The postoperative Karnofsky performance status was improved, stable and worsened in 22.4%, 43.9% and 33.7% of patients, respectively. Progression-free and overall survivals reached 5.1 months and 9.1 months, respectively.
Compared to other surgical strategies, total or subtotal resection improved the Karnofsky performance status (33.3% vs 12.5%,
p
|
| doi_str_mv | 10.1007/s00432-020-03474-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_hal_03299638v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2518566447</sourcerecordid><originalsourceid>FETCH-LOGICAL-c409t-72a06e8efc6a34fd874db50ac4705750cfc671110c7d7dec7540aa502ded85123</originalsourceid><addsrcrecordid>eNp9kc1u1DAUhS0EotPCC7BAlthQicD1X5wsq4pSpEFsYG3dcZwZV4k92MkgVrw6DilFYsHK8j3fOb7yIeQFg7cMQL_LAFLwCjhUIKSWVf2IbNgyYkKox2QDTLNKcVafkfOc76DcleZPyZkQom3bRm_Iz08YcO9GF6Y3tJ-DnXwMONA4TzaOLlMMHc1zOvlTmfpAkd4kF-yBjvMweVt8yVuaXfIFjj1lrKHYFY0ecfJFzvS7nw7UuuR2bhgw0f3g427APMURn5EnPQ7ZPb8_L8jXm_dfrm-r7ecPH6-vtpWV0E6V5gi1a1xvaxSy7xotu50CtFKD0gpsETRjDKzudOesVhIQFfDOdY1iXFyQyzX3gIM5Jj9i-mEienN7tTXLDARv21o0J1bY1yt7TPHb7PJkRp_tsntwcc6GyyUeRA0FffUPehfnVD6wUIo1qq6l1IXiK2VTzDm5_mEDBmap0qxVmlKl-V2lqYvp5X30vBtd92D5010BxArkIoW9S3_f_k_sL2_gqXQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2518566447</pqid></control><display><type>article</type><title>Management, functional outcomes and survival in a French multicentric series of 118 adult patients with cerebellar glioblastoma</title><source>SpringerNature Journals</source><creator>Picart, Thiébaud ; Meyronet, David ; Pallud, Johan ; Dumot, Chloé ; Metellus, Philippe ; Zouaoui, Sonia ; Berhouma, Moncef ; Ducray, François ; Bauchet, Luc ; Guyotat, Jacques</creator><creatorcontrib>Picart, Thiébaud ; Meyronet, David ; Pallud, Johan ; Dumot, Chloé ; Metellus, Philippe ; Zouaoui, Sonia ; Berhouma, Moncef ; Ducray, François ; Bauchet, Luc ; Guyotat, Jacques ; French Brain Tumor DataBase ; Club de Neuro-Oncologie of the Société Française de Neurochirurgie ; Club de Neuro-Oncologie of the Société Française de Neurochirurgie ; French Brain Tumor DataBase</creatorcontrib><description>Purpose
To analyze the outcomes and predictors in a large series of cerebellar glioblastomas in order to guide patient management.
Methods
The French brain tumor database and the Club de Neuro-Oncologie of the Société Française de Neurochirurgie retrospectively identified adult patients with cerebellar glioblastoma diagnosed between 2003 and 2017. Diagnosis was confirmed by a centralized neuropathological review.
Results
Data from 118 cerebellar glioblastoma patients were analyzed (mean age 55.9 years, 55.1% males). The clinical presentation associated raised intracranial pressure (50.8%), static cerebellar syndrome (68.6%), kinetic cerebellar syndrome (49.2%) and/or cranial nerve disorders (17.8%). Glioblastomas were hemispheric (55.9%), vermian (14.4%) or both (29.7%). Hydrocephalus was present in 49 patients (41.5%). Histologically, tumors corresponded either to IDH-wild-type or to K27-mutant glioblastomas.
Surgery consisted of total (12.7%), subtotal (35.6%), partial resection (33.9%) or biopsy (17.8%). The postoperative Karnofsky performance status was improved, stable and worsened in 22.4%, 43.9% and 33.7% of patients, respectively. Progression-free and overall survivals reached 5.1 months and 9.1 months, respectively.
Compared to other surgical strategies, total or subtotal resection improved the Karnofsky performance status (33.3% vs 12.5%,
p
< 0.001), prolonged progression-free and overall survivals (6.5 vs 4.3 months,
p
= 0.015 and 16.7 vs 6.2 months,
p
< 0.001, respectively) and had a comparable complication rate (40.4% vs 31.1%,
p
= 0.29). After total or subtotal resection, the functional outcomes were correlated with age (
p
= 0.004) and cerebellar hemispheric tumor location (
p
< 0.001) but not brainstem infiltration (
p
= 0.16).
Conclusion
In selected patients, maximal resection of cerebellar glioblastoma is associated with improved onco-functional outcomes, compared with less invasive procedures.</description><identifier>ISSN: 0171-5216</identifier><identifier>EISSN: 1432-1335</identifier><identifier>DOI: 10.1007/s00432-020-03474-6</identifier><identifier>PMID: 33399987</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Biopsy ; Brain cancer ; Brain stem ; Brain tumors ; Cancer ; Cancer Research ; Cerebellum ; Cranial nerves ; Glioblastoma ; Hematology ; Hydrocephalus ; Internal Medicine ; Life Sciences ; Medicine ; Medicine & Public Health ; Metastases ; Oncology ; Original Article – Clinical Oncology ; Patients ; Surgery</subject><ispartof>Journal of cancer research and clinical oncology, 2021-06, Vol.147 (6), p.1843-1856</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2021</rights><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2021.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c409t-72a06e8efc6a34fd874db50ac4705750cfc671110c7d7dec7540aa502ded85123</citedby><cites>FETCH-LOGICAL-c409t-72a06e8efc6a34fd874db50ac4705750cfc671110c7d7dec7540aa502ded85123</cites><orcidid>0000-0003-1852-071X ; 0000-0001-6494-6725 ; 0000-0001-9943-4578 ; 0000-0001-8987-8116 ; 0000-0002-1652-9844 ; 0000-0002-8150-5785 ; 0000-0003-1077-2496 ; 0000-0003-0467-3280</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00432-020-03474-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00432-020-03474-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33399987$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.inrae.fr/hal-03299638$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Picart, Thiébaud</creatorcontrib><creatorcontrib>Meyronet, David</creatorcontrib><creatorcontrib>Pallud, Johan</creatorcontrib><creatorcontrib>Dumot, Chloé</creatorcontrib><creatorcontrib>Metellus, Philippe</creatorcontrib><creatorcontrib>Zouaoui, Sonia</creatorcontrib><creatorcontrib>Berhouma, Moncef</creatorcontrib><creatorcontrib>Ducray, François</creatorcontrib><creatorcontrib>Bauchet, Luc</creatorcontrib><creatorcontrib>Guyotat, Jacques</creatorcontrib><creatorcontrib>French Brain Tumor DataBase</creatorcontrib><creatorcontrib>Club de Neuro-Oncologie of the Société Française de Neurochirurgie</creatorcontrib><creatorcontrib>Club de Neuro-Oncologie of the Société Française de Neurochirurgie</creatorcontrib><creatorcontrib>French Brain Tumor DataBase</creatorcontrib><title>Management, functional outcomes and survival in a French multicentric series of 118 adult patients with cerebellar glioblastoma</title><title>Journal of cancer research and clinical oncology</title><addtitle>J Cancer Res Clin Oncol</addtitle><addtitle>J Cancer Res Clin Oncol</addtitle><description>Purpose
To analyze the outcomes and predictors in a large series of cerebellar glioblastomas in order to guide patient management.
Methods
The French brain tumor database and the Club de Neuro-Oncologie of the Société Française de Neurochirurgie retrospectively identified adult patients with cerebellar glioblastoma diagnosed between 2003 and 2017. Diagnosis was confirmed by a centralized neuropathological review.
Results
Data from 118 cerebellar glioblastoma patients were analyzed (mean age 55.9 years, 55.1% males). The clinical presentation associated raised intracranial pressure (50.8%), static cerebellar syndrome (68.6%), kinetic cerebellar syndrome (49.2%) and/or cranial nerve disorders (17.8%). Glioblastomas were hemispheric (55.9%), vermian (14.4%) or both (29.7%). Hydrocephalus was present in 49 patients (41.5%). Histologically, tumors corresponded either to IDH-wild-type or to K27-mutant glioblastomas.
Surgery consisted of total (12.7%), subtotal (35.6%), partial resection (33.9%) or biopsy (17.8%). The postoperative Karnofsky performance status was improved, stable and worsened in 22.4%, 43.9% and 33.7% of patients, respectively. Progression-free and overall survivals reached 5.1 months and 9.1 months, respectively.
Compared to other surgical strategies, total or subtotal resection improved the Karnofsky performance status (33.3% vs 12.5%,
p
< 0.001), prolonged progression-free and overall survivals (6.5 vs 4.3 months,
p
= 0.015 and 16.7 vs 6.2 months,
p
< 0.001, respectively) and had a comparable complication rate (40.4% vs 31.1%,
p
= 0.29). After total or subtotal resection, the functional outcomes were correlated with age (
p
= 0.004) and cerebellar hemispheric tumor location (
p
< 0.001) but not brainstem infiltration (
p
= 0.16).
Conclusion
In selected patients, maximal resection of cerebellar glioblastoma is associated with improved onco-functional outcomes, compared with less invasive procedures.</description><subject>Biopsy</subject><subject>Brain cancer</subject><subject>Brain stem</subject><subject>Brain tumors</subject><subject>Cancer</subject><subject>Cancer Research</subject><subject>Cerebellum</subject><subject>Cranial nerves</subject><subject>Glioblastoma</subject><subject>Hematology</subject><subject>Hydrocephalus</subject><subject>Internal Medicine</subject><subject>Life Sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metastases</subject><subject>Oncology</subject><subject>Original Article – Clinical Oncology</subject><subject>Patients</subject><subject>Surgery</subject><issn>0171-5216</issn><issn>1432-1335</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kc1u1DAUhS0EotPCC7BAlthQicD1X5wsq4pSpEFsYG3dcZwZV4k92MkgVrw6DilFYsHK8j3fOb7yIeQFg7cMQL_LAFLwCjhUIKSWVf2IbNgyYkKox2QDTLNKcVafkfOc76DcleZPyZkQom3bRm_Iz08YcO9GF6Y3tJ-DnXwMONA4TzaOLlMMHc1zOvlTmfpAkd4kF-yBjvMweVt8yVuaXfIFjj1lrKHYFY0ecfJFzvS7nw7UuuR2bhgw0f3g427APMURn5EnPQ7ZPb8_L8jXm_dfrm-r7ecPH6-vtpWV0E6V5gi1a1xvaxSy7xotu50CtFKD0gpsETRjDKzudOesVhIQFfDOdY1iXFyQyzX3gIM5Jj9i-mEienN7tTXLDARv21o0J1bY1yt7TPHb7PJkRp_tsntwcc6GyyUeRA0FffUPehfnVD6wUIo1qq6l1IXiK2VTzDm5_mEDBmap0qxVmlKl-V2lqYvp5X30vBtd92D5010BxArkIoW9S3_f_k_sL2_gqXQ</recordid><startdate>20210601</startdate><enddate>20210601</enddate><creator>Picart, Thiébaud</creator><creator>Meyronet, David</creator><creator>Pallud, Johan</creator><creator>Dumot, Chloé</creator><creator>Metellus, Philippe</creator><creator>Zouaoui, Sonia</creator><creator>Berhouma, Moncef</creator><creator>Ducray, François</creator><creator>Bauchet, Luc</creator><creator>Guyotat, Jacques</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><general>Springer 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functional outcomes and survival in a French multicentric series of 118 adult patients with cerebellar glioblastoma</title><author>Picart, Thiébaud ; Meyronet, David ; Pallud, Johan ; Dumot, Chloé ; Metellus, Philippe ; Zouaoui, Sonia ; Berhouma, Moncef ; Ducray, François ; Bauchet, Luc ; Guyotat, Jacques</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c409t-72a06e8efc6a34fd874db50ac4705750cfc671110c7d7dec7540aa502ded85123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Biopsy</topic><topic>Brain cancer</topic><topic>Brain stem</topic><topic>Brain tumors</topic><topic>Cancer</topic><topic>Cancer Research</topic><topic>Cerebellum</topic><topic>Cranial nerves</topic><topic>Glioblastoma</topic><topic>Hematology</topic><topic>Hydrocephalus</topic><topic>Internal Medicine</topic><topic>Life Sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metastases</topic><topic>Oncology</topic><topic>Original Article – Clinical Oncology</topic><topic>Patients</topic><topic>Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Picart, Thiébaud</creatorcontrib><creatorcontrib>Meyronet, David</creatorcontrib><creatorcontrib>Pallud, Johan</creatorcontrib><creatorcontrib>Dumot, Chloé</creatorcontrib><creatorcontrib>Metellus, Philippe</creatorcontrib><creatorcontrib>Zouaoui, Sonia</creatorcontrib><creatorcontrib>Berhouma, Moncef</creatorcontrib><creatorcontrib>Ducray, François</creatorcontrib><creatorcontrib>Bauchet, Luc</creatorcontrib><creatorcontrib>Guyotat, Jacques</creatorcontrib><creatorcontrib>French Brain Tumor DataBase</creatorcontrib><creatorcontrib>Club de Neuro-Oncologie of the Société Française de Neurochirurgie</creatorcontrib><creatorcontrib>Club de Neuro-Oncologie of the Société Française de Neurochirurgie</creatorcontrib><creatorcontrib>French Brain Tumor DataBase</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community 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(HAL)</collection><jtitle>Journal of cancer research and clinical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Picart, Thiébaud</au><au>Meyronet, David</au><au>Pallud, Johan</au><au>Dumot, Chloé</au><au>Metellus, Philippe</au><au>Zouaoui, Sonia</au><au>Berhouma, Moncef</au><au>Ducray, François</au><au>Bauchet, Luc</au><au>Guyotat, Jacques</au><aucorp>French Brain Tumor DataBase</aucorp><aucorp>Club de Neuro-Oncologie of the Société Française de Neurochirurgie</aucorp><aucorp>Club de Neuro-Oncologie of the Société Française de Neurochirurgie</aucorp><aucorp>French Brain Tumor DataBase</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Management, functional outcomes and survival in a French multicentric series of 118 adult patients with cerebellar glioblastoma</atitle><jtitle>Journal of cancer research and clinical oncology</jtitle><stitle>J Cancer Res Clin Oncol</stitle><addtitle>J Cancer Res Clin Oncol</addtitle><date>2021-06-01</date><risdate>2021</risdate><volume>147</volume><issue>6</issue><spage>1843</spage><epage>1856</epage><pages>1843-1856</pages><issn>0171-5216</issn><eissn>1432-1335</eissn><abstract>Purpose
To analyze the outcomes and predictors in a large series of cerebellar glioblastomas in order to guide patient management.
Methods
The French brain tumor database and the Club de Neuro-Oncologie of the Société Française de Neurochirurgie retrospectively identified adult patients with cerebellar glioblastoma diagnosed between 2003 and 2017. Diagnosis was confirmed by a centralized neuropathological review.
Results
Data from 118 cerebellar glioblastoma patients were analyzed (mean age 55.9 years, 55.1% males). The clinical presentation associated raised intracranial pressure (50.8%), static cerebellar syndrome (68.6%), kinetic cerebellar syndrome (49.2%) and/or cranial nerve disorders (17.8%). Glioblastomas were hemispheric (55.9%), vermian (14.4%) or both (29.7%). Hydrocephalus was present in 49 patients (41.5%). Histologically, tumors corresponded either to IDH-wild-type or to K27-mutant glioblastomas.
Surgery consisted of total (12.7%), subtotal (35.6%), partial resection (33.9%) or biopsy (17.8%). The postoperative Karnofsky performance status was improved, stable and worsened in 22.4%, 43.9% and 33.7% of patients, respectively. Progression-free and overall survivals reached 5.1 months and 9.1 months, respectively.
Compared to other surgical strategies, total or subtotal resection improved the Karnofsky performance status (33.3% vs 12.5%,
p
< 0.001), prolonged progression-free and overall survivals (6.5 vs 4.3 months,
p
= 0.015 and 16.7 vs 6.2 months,
p
< 0.001, respectively) and had a comparable complication rate (40.4% vs 31.1%,
p
= 0.29). After total or subtotal resection, the functional outcomes were correlated with age (
p
= 0.004) and cerebellar hemispheric tumor location (
p
< 0.001) but not brainstem infiltration (
p
= 0.16).
Conclusion
In selected patients, maximal resection of cerebellar glioblastoma is associated with improved onco-functional outcomes, compared with less invasive procedures.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>33399987</pmid><doi>10.1007/s00432-020-03474-6</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0003-1852-071X</orcidid><orcidid>https://orcid.org/0000-0001-6494-6725</orcidid><orcidid>https://orcid.org/0000-0001-9943-4578</orcidid><orcidid>https://orcid.org/0000-0001-8987-8116</orcidid><orcidid>https://orcid.org/0000-0002-1652-9844</orcidid><orcidid>https://orcid.org/0000-0002-8150-5785</orcidid><orcidid>https://orcid.org/0000-0003-1077-2496</orcidid><orcidid>https://orcid.org/0000-0003-0467-3280</orcidid></addata></record> |
| fulltext | fulltext |
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| ispartof | Journal of cancer research and clinical oncology, 2021-06, Vol.147 (6), p.1843-1856 |
| issn | 0171-5216 1432-1335 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_03299638v1 |
| source | SpringerNature Journals |
| subjects | Biopsy Brain cancer Brain stem Brain tumors Cancer Cancer Research Cerebellum Cranial nerves Glioblastoma Hematology Hydrocephalus Internal Medicine Life Sciences Medicine Medicine & Public Health Metastases Oncology Original Article – Clinical Oncology Patients Surgery |
| title | Management, functional outcomes and survival in a French multicentric series of 118 adult patients with cerebellar glioblastoma |
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