Micro liquid chromatography coupled with evaporative light scattering detector at ambient and high temperature: Optimization of the nebulization cell geometry
The recent developments in liquid chromatography (LC) are mainly dedicated to both system miniaturization (micro-, capillary-, and nano-LC) and analysis time decrease (fast-, and ultra-fast-LC). For the latter, several strategies can be used, and high temperature liquid chromatography (HTLC) seems v...
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| Veröffentlicht in: | Journal of Chromatography A 2008-05, Vol.1192 (1), p.103-112 |
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| container_title | Journal of Chromatography A |
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| creator | Guillarme, D. Rudaz, S. Schelling, C. Dreux, M. Veuthey, J.-L. |
| description | The recent developments in liquid chromatography (LC) are mainly dedicated to both system miniaturization (micro-, capillary-, and nano-LC) and analysis time decrease (fast-, and ultra-fast-LC). For the latter, several strategies can be used, and high temperature liquid chromatography (HTLC) seems very promising and easy to implement, especially in miniaturized system. In LC, the evaporative light scattering detector (ELSD) is considered an attractive alternative to conventional detector such as UV–vis due to its versatility and quasi-universality. Therefore, the compatibility of ELSD with μ-LC and μ-HTLC was investigated for several pharmaceutical compounds of interest. The nebulization process appeared to be the most critical parameter for performing the coupling and maintaining an efficient separation. Therefore, appropriate modifications in the nebulization cell geometry were brought to make ELSD fully compatible with μ-LC. The impact of optimized nebulization cell on chromatographic performance was evaluated in terms of efficiency and sensitivity. Finally, highly efficient, sensitive and fast separations of pharmaceutical drugs were performed with both techniques and the customized nebulization cell design. |
| doi_str_mv | 10.1016/j.chroma.2008.03.034 |
| format | Article |
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For the latter, several strategies can be used, and high temperature liquid chromatography (HTLC) seems very promising and easy to implement, especially in miniaturized system. In LC, the evaporative light scattering detector (ELSD) is considered an attractive alternative to conventional detector such as UV–vis due to its versatility and quasi-universality. Therefore, the compatibility of ELSD with μ-LC and μ-HTLC was investigated for several pharmaceutical compounds of interest. The nebulization process appeared to be the most critical parameter for performing the coupling and maintaining an efficient separation. Therefore, appropriate modifications in the nebulization cell geometry were brought to make ELSD fully compatible with μ-LC. The impact of optimized nebulization cell on chromatographic performance was evaluated in terms of efficiency and sensitivity. Finally, highly efficient, sensitive and fast separations of pharmaceutical drugs were performed with both techniques and the customized nebulization cell design.</description><identifier>ISSN: 0021-9673</identifier><identifier>EISSN: 1873-3778</identifier><identifier>DOI: 10.1016/j.chroma.2008.03.034</identifier><identifier>PMID: 18395734</identifier><identifier>CODEN: JOCRAM</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Analysis ; Analytical chemistry ; Artemisinins - isolation & purification ; Biological and medical sciences ; Chemistry ; Chromatographic methods and physical methods associated with chromatography ; Chromatography, Liquid - methods ; ELSD ; Evaporative light scattering detector ; Exact sciences and technology ; Fast liquid chromatography ; General pharmacology ; High temperature liquid chromatography ; HTLC ; Life Sciences ; Light ; Medical sciences ; Micro-LC ; Miniaturization ; Multivariate Analysis ; Nebulizers and Vaporizers ; Other chromatographic methods ; Pharmaceutical Preparations - isolation & purification ; Pharmacology. Drug treatments ; Scattering, Radiation ; Temperature</subject><ispartof>Journal of Chromatography A, 2008-05, Vol.1192 (1), p.103-112</ispartof><rights>2008 Elsevier B.V.</rights><rights>2008 INIST-CNRS</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c448t-5d1ebc4ffde62d4f43e80df311adcbd619db849da5b20250ffc62fb5b8bc26293</citedby><cites>FETCH-LOGICAL-c448t-5d1ebc4ffde62d4f43e80df311adcbd619db849da5b20250ffc62fb5b8bc26293</cites><orcidid>0000-0002-6607-4796</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0021967308005050$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20332581$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18395734$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-03295891$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Guillarme, D.</creatorcontrib><creatorcontrib>Rudaz, S.</creatorcontrib><creatorcontrib>Schelling, C.</creatorcontrib><creatorcontrib>Dreux, M.</creatorcontrib><creatorcontrib>Veuthey, J.-L.</creatorcontrib><title>Micro liquid chromatography coupled with evaporative light scattering detector at ambient and high temperature: Optimization of the nebulization cell geometry</title><title>Journal of Chromatography A</title><addtitle>J Chromatogr A</addtitle><description>The recent developments in liquid chromatography (LC) are mainly dedicated to both system miniaturization (micro-, capillary-, and nano-LC) and analysis time decrease (fast-, and ultra-fast-LC). For the latter, several strategies can be used, and high temperature liquid chromatography (HTLC) seems very promising and easy to implement, especially in miniaturized system. In LC, the evaporative light scattering detector (ELSD) is considered an attractive alternative to conventional detector such as UV–vis due to its versatility and quasi-universality. Therefore, the compatibility of ELSD with μ-LC and μ-HTLC was investigated for several pharmaceutical compounds of interest. The nebulization process appeared to be the most critical parameter for performing the coupling and maintaining an efficient separation. Therefore, appropriate modifications in the nebulization cell geometry were brought to make ELSD fully compatible with μ-LC. The impact of optimized nebulization cell on chromatographic performance was evaluated in terms of efficiency and sensitivity. Finally, highly efficient, sensitive and fast separations of pharmaceutical drugs were performed with both techniques and the customized nebulization cell design.</description><subject>Analysis</subject><subject>Analytical chemistry</subject><subject>Artemisinins - isolation & purification</subject><subject>Biological and medical sciences</subject><subject>Chemistry</subject><subject>Chromatographic methods and physical methods associated with chromatography</subject><subject>Chromatography, Liquid - methods</subject><subject>ELSD</subject><subject>Evaporative light scattering detector</subject><subject>Exact sciences and technology</subject><subject>Fast liquid chromatography</subject><subject>General pharmacology</subject><subject>High temperature liquid chromatography</subject><subject>HTLC</subject><subject>Life Sciences</subject><subject>Light</subject><subject>Medical sciences</subject><subject>Micro-LC</subject><subject>Miniaturization</subject><subject>Multivariate Analysis</subject><subject>Nebulizers and Vaporizers</subject><subject>Other chromatographic methods</subject><subject>Pharmaceutical Preparations - isolation & purification</subject><subject>Pharmacology. Drug treatments</subject><subject>Scattering, Radiation</subject><subject>Temperature</subject><issn>0021-9673</issn><issn>1873-3778</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kd2KFDEQhYMo7jr6BqK5UfBixvz0T9oLYVnUFUb2Qvc6pJPKdIbuTm-SHhkfxmc1Q4_rnVBQUHx1qjgHoZeUbCih1fv9RnfBD2rDCBEbwnMVj9AlFTVf87oWj9ElIYyum6rmF-hZjHtCaE1q9hRdUMGbsubFJfr9zengce_uZ2fwopj8LqipO2Lt56kHg3-61GE4qMkHldwBMr7rEo5apQTBjTtsIIFOPmCVsBpaB2Puo8FdBnGCYYK8OQf4gG-n5Ab3K-v4EXuLUwd4hHbu_8409D3egR8gheNz9MSqPsKLc1-hu8-fflzfrLe3X75eX23XuihEWpeGQqsLaw1UzBS24CCIsZxSZXRrKtqYVhSNUWXLCCuJtbpiti1b0WpWsYav0LtFt1O9nIIbVDhKr5y8udrK04xw1pSioQea2bcLOwV_P0NMcnDx9LUawc9RVg0tWZUtXqFiAbPDMQawD8qUyFOGci8Xx-Upw3wjV5HXXp3153YA82_pHFoG3pwBlSPobVCjdvGBY4RzVorTo68Xziov1S5k5u47I5TnY6KpK56JjwsB2duDgyCjztlpMC7kPKXx7v-__gHhlso-</recordid><startdate>20080523</startdate><enddate>20080523</enddate><creator>Guillarme, D.</creator><creator>Rudaz, S.</creator><creator>Schelling, C.</creator><creator>Dreux, M.</creator><creator>Veuthey, J.-L.</creator><general>Elsevier B.V</general><general>Amsterdam; New York: Elsevier</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-6607-4796</orcidid></search><sort><creationdate>20080523</creationdate><title>Micro liquid chromatography coupled with evaporative light scattering detector at ambient and high temperature: Optimization of the nebulization cell geometry</title><author>Guillarme, D. ; Rudaz, S. ; Schelling, C. ; Dreux, M. ; Veuthey, J.-L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c448t-5d1ebc4ffde62d4f43e80df311adcbd619db849da5b20250ffc62fb5b8bc26293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Analysis</topic><topic>Analytical chemistry</topic><topic>Artemisinins - isolation & purification</topic><topic>Biological and medical sciences</topic><topic>Chemistry</topic><topic>Chromatographic methods and physical methods associated with chromatography</topic><topic>Chromatography, Liquid - methods</topic><topic>ELSD</topic><topic>Evaporative light scattering detector</topic><topic>Exact sciences and technology</topic><topic>Fast liquid chromatography</topic><topic>General pharmacology</topic><topic>High temperature liquid chromatography</topic><topic>HTLC</topic><topic>Life Sciences</topic><topic>Light</topic><topic>Medical sciences</topic><topic>Micro-LC</topic><topic>Miniaturization</topic><topic>Multivariate Analysis</topic><topic>Nebulizers and Vaporizers</topic><topic>Other chromatographic methods</topic><topic>Pharmaceutical Preparations - isolation & purification</topic><topic>Pharmacology. Drug treatments</topic><topic>Scattering, Radiation</topic><topic>Temperature</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Guillarme, D.</creatorcontrib><creatorcontrib>Rudaz, S.</creatorcontrib><creatorcontrib>Schelling, C.</creatorcontrib><creatorcontrib>Dreux, M.</creatorcontrib><creatorcontrib>Veuthey, J.-L.</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Journal of Chromatography A</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Guillarme, D.</au><au>Rudaz, S.</au><au>Schelling, C.</au><au>Dreux, M.</au><au>Veuthey, J.-L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Micro liquid chromatography coupled with evaporative light scattering detector at ambient and high temperature: Optimization of the nebulization cell geometry</atitle><jtitle>Journal of Chromatography A</jtitle><addtitle>J Chromatogr A</addtitle><date>2008-05-23</date><risdate>2008</risdate><volume>1192</volume><issue>1</issue><spage>103</spage><epage>112</epage><pages>103-112</pages><issn>0021-9673</issn><eissn>1873-3778</eissn><coden>JOCRAM</coden><abstract>The recent developments in liquid chromatography (LC) are mainly dedicated to both system miniaturization (micro-, capillary-, and nano-LC) and analysis time decrease (fast-, and ultra-fast-LC). For the latter, several strategies can be used, and high temperature liquid chromatography (HTLC) seems very promising and easy to implement, especially in miniaturized system. In LC, the evaporative light scattering detector (ELSD) is considered an attractive alternative to conventional detector such as UV–vis due to its versatility and quasi-universality. Therefore, the compatibility of ELSD with μ-LC and μ-HTLC was investigated for several pharmaceutical compounds of interest. The nebulization process appeared to be the most critical parameter for performing the coupling and maintaining an efficient separation. Therefore, appropriate modifications in the nebulization cell geometry were brought to make ELSD fully compatible with μ-LC. The impact of optimized nebulization cell on chromatographic performance was evaluated in terms of efficiency and sensitivity. 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| ispartof | Journal of Chromatography A, 2008-05, Vol.1192 (1), p.103-112 |
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| subjects | Analysis Analytical chemistry Artemisinins - isolation & purification Biological and medical sciences Chemistry Chromatographic methods and physical methods associated with chromatography Chromatography, Liquid - methods ELSD Evaporative light scattering detector Exact sciences and technology Fast liquid chromatography General pharmacology High temperature liquid chromatography HTLC Life Sciences Light Medical sciences Micro-LC Miniaturization Multivariate Analysis Nebulizers and Vaporizers Other chromatographic methods Pharmaceutical Preparations - isolation & purification Pharmacology. Drug treatments Scattering, Radiation Temperature |
| title | Micro liquid chromatography coupled with evaporative light scattering detector at ambient and high temperature: Optimization of the nebulization cell geometry |
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