Impaired adhesion of neutrophils expressing Slc44a2/HNA-3b to VWF protects against NETosis under venous shear rates

Genome-wide association studies linked expression of the human neutrophil antigen 3b (HNA-3b) epitope on the Slc44a2 protein with a 30% decreased risk of venous thrombosis (VT) in humans. Slc44a2 is a ubiquitous transmembrane protein identified as a receptor for von Willebrand factor (VWF). To expla...

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Veröffentlicht in:	Blood 2021-04, Vol.137 (16), p.2256-2266
Hauptverfasser:	Zirka, Gaïa, Robert, Philippe, Tilburg, Julia, Tishkova, Victoria, Maracle, Chrissta X., Legendre, Paulette, van Vlijmen, Bart J.M., Alessi, Marie-Christine, Lenting, Peter J., Morange, Pierre-Emmanuel, Thomas, Grace M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Circulation Cardiology and cardiovascular system Cell Adhesion Cell Behavior Cells, Cultured Cellular Biology Extracellular Traps - genetics Extracellular Traps - metabolism Gene Expression HEK293 Cells Hematology Human health and pathology Humans Isoantigens - genetics Isoantigens - metabolism Life Sciences Male Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Membrane Transport Proteins - genetics Membrane Transport Proteins - metabolism Mice Mice, Inbred C57BL Neutrophils - cytology Neutrophils - metabolism Venous Thrombosis - genetics Venous Thrombosis - metabolism von Willebrand Factor - metabolism
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