Interest of extracellular vesicles in regards to lipid nanoparticle based systems for intracellular protein delivery
[Display omitted] Compared to chemicals that continue to dominate the overall pharmaceutical market, protein therapeutics offer the advantages of higher specificity, greater activity, and reduced toxicity. While nearly all existing therapeutic proteins were developed against soluble or extracellular...
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| Veröffentlicht in: | Advanced drug delivery reviews 2021-09, Vol.176, p.113837-113837, Article 113837 |
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| container_title | Advanced drug delivery reviews |
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| creator | Le Saux, Sarah Aubert-Pouëssel, Anne Mohamed, Khaled Elhady Martineau, Pierre Guglielmi, Laurence Devoisselle, Jean-Marie Legrand, Philippe Chopineau, Joël Morille, Marie |
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Compared to chemicals that continue to dominate the overall pharmaceutical market, protein therapeutics offer the advantages of higher specificity, greater activity, and reduced toxicity. While nearly all existing therapeutic proteins were developed against soluble or extracellular targets, the ability for proteins to enter cells and target intracellular compartments can significantly broaden their utility for a myriad of exiting targets. Given their physical, chemical, biological instability that could induce adverse effects, and their limited ability to cross cell membranes, delivery systems are required to fully reveal their biological potential. In this context, as natural protein nanocarriers, extracellular vesicles (EVs) hold great promise. Nevertheless, if not present naturally, bringing an interest protein into EV is not an easy task. In this review, we will explore methods used to load extrinsic protein into EVs and compare these natural vectors to their close synthetic counterparts, liposomes/lipid nanoparticles, to induce intracellular protein delivery. |
| doi_str_mv | 10.1016/j.addr.2021.113837 |
| format | Article |
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Compared to chemicals that continue to dominate the overall pharmaceutical market, protein therapeutics offer the advantages of higher specificity, greater activity, and reduced toxicity. While nearly all existing therapeutic proteins were developed against soluble or extracellular targets, the ability for proteins to enter cells and target intracellular compartments can significantly broaden their utility for a myriad of exiting targets. Given their physical, chemical, biological instability that could induce adverse effects, and their limited ability to cross cell membranes, delivery systems are required to fully reveal their biological potential. In this context, as natural protein nanocarriers, extracellular vesicles (EVs) hold great promise. Nevertheless, if not present naturally, bringing an interest protein into EV is not an easy task. In this review, we will explore methods used to load extrinsic protein into EVs and compare these natural vectors to their close synthetic counterparts, liposomes/lipid nanoparticles, to induce intracellular protein delivery.</description><identifier>ISSN: 0169-409X</identifier><identifier>EISSN: 1872-8294</identifier><identifier>DOI: 10.1016/j.addr.2021.113837</identifier><identifier>PMID: 34144089</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Biotechnology ; Cytoplasmic delivery ; Drug Delivery Systems ; Exosomes ; Extracellular Vesicles - metabolism ; Humans ; Life Sciences ; Liposomes ; Macromolecules delivery ; Microvesicles ; Nanoparticles ; Pharmaceutical sciences ; Proteins - administration & dosage ; Proteins - adverse effects ; Proteins - metabolism ; Therapeutic proteins ; Vectorisation</subject><ispartof>Advanced drug delivery reviews, 2021-09, Vol.176, p.113837-113837, Article 113837</ispartof><rights>2021 Elsevier B.V.</rights><rights>Copyright © 2021 Elsevier B.V. All rights reserved.</rights><rights>Attribution - NonCommercial</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c434t-78cd516632f46da0870e2323ef588e1d664cb12305937f9edd016447e9a7caf63</citedby><cites>FETCH-LOGICAL-c434t-78cd516632f46da0870e2323ef588e1d664cb12305937f9edd016447e9a7caf63</cites><orcidid>0000-0002-7993-7183 ; 0000-0001-8224-7346 ; 0000-0001-8307-0167</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0169409X21002295$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34144089$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-03292014$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Le Saux, Sarah</creatorcontrib><creatorcontrib>Aubert-Pouëssel, Anne</creatorcontrib><creatorcontrib>Mohamed, Khaled Elhady</creatorcontrib><creatorcontrib>Martineau, Pierre</creatorcontrib><creatorcontrib>Guglielmi, Laurence</creatorcontrib><creatorcontrib>Devoisselle, Jean-Marie</creatorcontrib><creatorcontrib>Legrand, Philippe</creatorcontrib><creatorcontrib>Chopineau, Joël</creatorcontrib><creatorcontrib>Morille, Marie</creatorcontrib><title>Interest of extracellular vesicles in regards to lipid nanoparticle based systems for intracellular protein delivery</title><title>Advanced drug delivery reviews</title><addtitle>Adv Drug Deliv Rev</addtitle><description>[Display omitted]
Compared to chemicals that continue to dominate the overall pharmaceutical market, protein therapeutics offer the advantages of higher specificity, greater activity, and reduced toxicity. While nearly all existing therapeutic proteins were developed against soluble or extracellular targets, the ability for proteins to enter cells and target intracellular compartments can significantly broaden their utility for a myriad of exiting targets. Given their physical, chemical, biological instability that could induce adverse effects, and their limited ability to cross cell membranes, delivery systems are required to fully reveal their biological potential. In this context, as natural protein nanocarriers, extracellular vesicles (EVs) hold great promise. Nevertheless, if not present naturally, bringing an interest protein into EV is not an easy task. 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Aubert-Pouëssel, Anne ; Mohamed, Khaled Elhady ; Martineau, Pierre ; Guglielmi, Laurence ; Devoisselle, Jean-Marie ; Legrand, Philippe ; Chopineau, Joël ; Morille, Marie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c434t-78cd516632f46da0870e2323ef588e1d664cb12305937f9edd016447e9a7caf63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Animals</topic><topic>Biotechnology</topic><topic>Cytoplasmic delivery</topic><topic>Drug Delivery Systems</topic><topic>Exosomes</topic><topic>Extracellular Vesicles - metabolism</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Liposomes</topic><topic>Macromolecules delivery</topic><topic>Microvesicles</topic><topic>Nanoparticles</topic><topic>Pharmaceutical sciences</topic><topic>Proteins - administration & dosage</topic><topic>Proteins - adverse effects</topic><topic>Proteins - metabolism</topic><topic>Therapeutic proteins</topic><topic>Vectorisation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Le Saux, Sarah</creatorcontrib><creatorcontrib>Aubert-Pouëssel, Anne</creatorcontrib><creatorcontrib>Mohamed, Khaled Elhady</creatorcontrib><creatorcontrib>Martineau, Pierre</creatorcontrib><creatorcontrib>Guglielmi, Laurence</creatorcontrib><creatorcontrib>Devoisselle, Jean-Marie</creatorcontrib><creatorcontrib>Legrand, Philippe</creatorcontrib><creatorcontrib>Chopineau, Joël</creatorcontrib><creatorcontrib>Morille, Marie</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><jtitle>Advanced drug delivery reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Le Saux, Sarah</au><au>Aubert-Pouëssel, Anne</au><au>Mohamed, Khaled Elhady</au><au>Martineau, Pierre</au><au>Guglielmi, Laurence</au><au>Devoisselle, Jean-Marie</au><au>Legrand, Philippe</au><au>Chopineau, Joël</au><au>Morille, Marie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interest of extracellular vesicles in regards to lipid nanoparticle based systems for intracellular protein delivery</atitle><jtitle>Advanced drug delivery reviews</jtitle><addtitle>Adv Drug Deliv Rev</addtitle><date>2021-09-01</date><risdate>2021</risdate><volume>176</volume><spage>113837</spage><epage>113837</epage><pages>113837-113837</pages><artnum>113837</artnum><issn>0169-409X</issn><eissn>1872-8294</eissn><abstract>[Display omitted]
Compared to chemicals that continue to dominate the overall pharmaceutical market, protein therapeutics offer the advantages of higher specificity, greater activity, and reduced toxicity. While nearly all existing therapeutic proteins were developed against soluble or extracellular targets, the ability for proteins to enter cells and target intracellular compartments can significantly broaden their utility for a myriad of exiting targets. Given their physical, chemical, biological instability that could induce adverse effects, and their limited ability to cross cell membranes, delivery systems are required to fully reveal their biological potential. In this context, as natural protein nanocarriers, extracellular vesicles (EVs) hold great promise. Nevertheless, if not present naturally, bringing an interest protein into EV is not an easy task. In this review, we will explore methods used to load extrinsic protein into EVs and compare these natural vectors to their close synthetic counterparts, liposomes/lipid nanoparticles, to induce intracellular protein delivery.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>34144089</pmid><doi>10.1016/j.addr.2021.113837</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-7993-7183</orcidid><orcidid>https://orcid.org/0000-0001-8224-7346</orcidid><orcidid>https://orcid.org/0000-0001-8307-0167</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0169-409X |
| ispartof | Advanced drug delivery reviews, 2021-09, Vol.176, p.113837-113837, Article 113837 |
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| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_03292014v1 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Biotechnology Cytoplasmic delivery Drug Delivery Systems Exosomes Extracellular Vesicles - metabolism Humans Life Sciences Liposomes Macromolecules delivery Microvesicles Nanoparticles Pharmaceutical sciences Proteins - administration & dosage Proteins - adverse effects Proteins - metabolism Therapeutic proteins Vectorisation |
| title | Interest of extracellular vesicles in regards to lipid nanoparticle based systems for intracellular protein delivery |
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